Integrated Clinical Neuroscience Training for Translational Research

转化研究综合临床神经科学培训

• 批准号: 10411191
• 负责人: LISA A ECKEL
• 金额: $ 18.77万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411191
• 关键词: Clinical; Neurosciences; Training; Translational Research

The Integrated Clinical Neuroscience (ICN) Training Program, operating within the Clinical Psychology and interdisciplinary Neuroscience programs at Florida State University for the past 9 years, seeks to train the next generation of investigators to become leaders in translational research and make major advances in several areas of psychopathology characterized by dysregulated behaviors including eating disorders, depression, anxiety disorders, suicidality, post-traumatic stress disorder, and substance use disorders. These problems are associated with significant psychological and medical morbidity, elevated mortality, and high economic burden. This underscores the need for research that translates the neural mechanisms underlying normal and abnormal behavior in animals into clinical studies of the causes and treatment of mental disorders. However, segregation of doctoral training in Clinical Psychology and Neuroscience, with separate courses, lab experiences, and exposure to outside speakers, impedes new scientists’ preparation to undertake translational approaches in their own research. The ICN Training Program was designed to break down these barriers. Here, we seek continued funding to provide integrated instruction, research experience, and mentorship to 4 predoctoral ICN trainees earning PhDs in Clinical Psychology and Neuroscience through 1) cross-area courses, 2) cross-area lab rotations, 3) a Special Speaker Series in which trainees present their research to invited scholars conducting translational science, and these scholars present their work to trainees, our participating Departments, and the community, 4) presentation of research at conferences and in published papers, and 5) instruction in grant writing, data science, and cross-area instruction in the responsible conduct of research. Predoctoral trainees apply for the ICN Training Program by describing research they plan to conduct in collaboration with their primary advisor and cross-area mentor, classes they will complete, and how this cross-area exposure will contribute to their career development as translational scientists. Students are typically appointed for two years beginning in their 3rd to 4th year to ensure selection of the most promising trainees who have completed basic program requirements and established research interests that can be extended by a cross-area lab rotation. Our training model has supported a total of 19 trainees. Among the 13 ICN trainees who have completed the Ph.D., 92% have continued in research careers (with 4 currently in tenure-track positions) and 77% have received highly competitive fellowships and independent research grants. Training faculty, selected for their cross-area connections in research addressing dysregulated behaviors, continue to excel in securing grant funding and training students for research careers with strong publication records. Continuation of the ICN Training Grant for an additional 5 years will build upon our accomplishments and ensure that a third cohort of Ph.D. students is ideally positioned to initiate cutting-edge translational research to address mental disorders characterized by dysregulated behaviors.

综合临床神经科学(ICN)培训计划，在临床心理学和 佛罗里达州立大学过去9年的跨学科神经科学项目，寻求培养下一代 一代研究人员将成为翻译研究的领导者，并在几个方面取得重大进展 精神病理学的领域，以饮食失调、抑郁、 焦虑症、自杀、创伤后应激障碍和药物使用障碍。这些问题是 与严重的心理和医疗发病率、高死亡率和高经济负担有关。 这突显了需要进行研究，以翻译正常和 将动物行为异常纳入临床研究，探讨精神障碍的病因和治疗方法。然而， 临床心理学和神经科学博士培训的分离，有单独的课程，实验室 经验和接触外部演讲者，阻碍了新科学家进行翻译的准备 在他们自己的研究中采用了一些方法。ICN培训计划旨在打破这些障碍。 在这里，我们寻求继续提供资金，为4名学生提供综合教学、研究经验和指导 ICN博士前实习生通过1)跨领域获得临床心理学和神经科学博士学位 课程，2)跨区域实验室轮换，3)特殊演讲者系列，学员在其中介绍他们的研究 翻译科学的特邀学者，这些学者向学员介绍他们的工作，我们的 参与部门和社区，4)在会议和出版的报告中介绍研究 论文，以及5)关于拨款撰写、数据科学和负责行为的跨领域指导 研究的成果。博士前实习生通过描述他们计划进行的研究来申请ICN培训计划 与他们的首席顾问和跨区域导师合作进行，他们将完成的课程，以及如何完成 这种跨领域的接触将有助于他们作为翻译科学家的职业发展。学生们 通常从第三到第四年开始任命，为期两年，以确保挑选出最有前途的人 已完成基本计划要求并建立研究兴趣的受训人员 通过跨区域的实验室轮换进行扩展。我们的培训模式共支持了19名学员。在13个国家中 完成博士学位的ICN学员中，92%的人继续从事研究工作(目前有4人 终身教职)，77%的人获得了竞争激烈的奖学金和独立研究 资助金。培训教师，因为他们在解决监管失调的研究中建立了跨领域的联系 行为，继续在获得拨款和培养学生从事研究职业生涯方面表现出色 出版记录。ICN培训补助金再延续5年将建立在我们的 并确保第三批博士生处于理想的地位，可以开创尖端技术 旨在解决以行为失调为特征的精神障碍的翻译性研究。