Microscope Based Brain Positioning System for Anatomical Navigation
用于解剖导航的基于显微镜的大脑定位系统
基本信息
- 批准号:8315095
- 负责人:
- 金额:$ 15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-04-13 至 2012-10-12
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimalsAreaAtlasesBase of the BrainBasic Behavioral ScienceBiotechnologyBrainBrain DiseasesBrain PathologyBrain regionCollaborationsCommunitiesComplexComputer softwareConsultConsultationsDataDevelopmentFaceFeasibility StudiesFeedbackGoalsHistologicImageImageryIndividualInstitutesInvestigationKnowledgeLeftLightLight MicroscopeLocationManualsManufacturer NameMapsMethodsMicroscopeMicroscopicMicroscopyNamesNational Institute of Mental HealthNervous system structureNetherlandsNeuroanatomyNeurosciencesNeurosciences ResearchPharmacologic SubstancePhasePositioning AttributePrintingProceduresProcessResearchResearch PersonnelSavingsScienceScientistSliceSlideSocietiesStaining methodStainsStructureSystemTechniquesTestingThickTimeTissuesValidationVisualbasedata sharingdigitaldigital imagingexperienceimprovedinnovationinterestnovelphase 2 studyprototypereconstructionresearch and developmenttooltreatment strategyusabilityvirtual
项目摘要
DESCRIPTION (provided by applicant): Neuromorphologic analyses at the light microscopic level have significantly contributed to our understanding of the function and pathology of the brain. We propose to develop an integrated commercial product for providing automatic, immediate feedback about the neuroanatomic borders and name of a brain region that is currently being inspected under a light microscope or in a virtual slide. Currently, identificationof a particular region of interest is accomplished by making manual comparisons between the histologic brain section under the microscope and a digital or print brain atlas which can be tedious and cumbersome. The proposed system will integrate existing 3D brain atlases and an investigator's own microscope system to provide neuroanatomic location information about the brain section under study. It will also provide the option to generate individual, customized 3D brain atlases created on the basis of histologic brain sections from the investigator's own lab. We believe that introduction of the robust commercial system proposed here will greatly enable studies in basic neuroscience, pharmaceutical, and biotechnology research and development fields by leading to the potential to analyze many more brain regions than is currently initiated. Thus, this innovative system will provide an improved basis for developing novel treatment strategies for complex brain diseases.
PUBLIC HEALTH RELEVANCE: Microscopic analyses of histologic brain sections yield important information about the organization and composition of the nervous system; however these analyses require extensive knowledge of neuroanatomic boundaries and time-intensive consultation with printed or digital atlases. This project commercializes an innovative system for providing neuroanatomic location information about the region currently in view on the basis of both existing and user-generated customized 3D brain atlases. Providing immediate feedback about the name and location of the brain region currently under study at the microscope will provide an improved basis for developing novel treatment strategies for complex brain diseases.
描述(由申请人提供):在光学显微镜水平上的神经形态学分析对我们理解大脑的功能和病理学有重要贡献。我们建议开发一种集成的商业产品,用于提供有关神经解剖学边界和当前正在光学显微镜下或虚拟载玻片中检查的脑区域名称的自动、即时反馈。目前,通过在显微镜下的组织学脑切片和数字或打印的脑图谱之间进行手动比较来完成特定感兴趣区域的识别,这可能是繁琐和麻烦的。该系统将整合现有的3D大脑图谱和研究者自己的显微镜系统,以提供有关研究中大脑切片的神经解剖位置信息。它还将提供生成基于研究者自己实验室的组织学脑切片创建的个体定制3D脑图谱的选项。我们相信,引入这里提出的强大的商业系统将大大使基础神经科学,制药和生物技术研究和开发领域的研究,导致分析比目前启动的更多的大脑区域的潜力。因此,这一创新系统将为开发复杂脑部疾病的新治疗策略提供更好的基础。
公共卫生关系:脑组织切片的显微镜分析产生关于神经系统的组织和组成的重要信息;然而,这些分析需要广泛的神经解剖学边界知识和印刷或数字地图集的时间密集型咨询。该项目商业化的创新系统,提供神经解剖位置信息的区域,目前在现有的和用户生成的定制三维大脑图谱的基础上。提供关于目前在显微镜下研究的大脑区域的名称和位置的即时反馈,将为开发复杂大脑疾病的新治疗策略提供更好的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul Angstman其他文献
Paul Angstman的其他文献
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