ID OF SNPS FOR ADMIXTURE MAPPING OF A QTL FOR TEMPERAMENT IN RHESUS MACAQUES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是确定足够数量的祖先信息标记物（AIMS;单核苷酸多态性，或SNPS，最大程度上不同的频率之间的印度和中国恒河猴）和基因型，他们在印度/中国杂交恒河猴的不同比例的祖先（之间的？和？中国血统）的措施，“气质”已经量化在以前的研究。 通过在所有染色体上比较具有“低”和“高”气质的杂交动物的SNP频率，将试图确定恒河猴基因组中影响“气质”的基因的位置，这是一种称为“混合作图”的全基因组关联方法。"

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of this study is to identify a sufficient number of ancestry informative markers (AIMS; single nucleotide polymorphisms, or SNPS, that maximally differ in frequency between Indian and Chinese rhesus macaques) and genotype them in Indian/Chinese hybrid rhesus macaques of varying proportions of ancestry(between ¿ and ¿ Chinese ancestry) for which measures of "temperament" have been quantified in a previous study. By comparing SNP frequencies of hybrid animals with "low" versus "high" temperament across all chromosomes, an attempt will be made to identify locations of genes in the rhesus genome that influence "temperament," a methodology of whole genome association called "admixture mapping."