ID OF SNPS FOR ADMIXTURE MAPPING OF A QTL FOR TEMPERAMENT IN RHESUS MACAQUES

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是确定足够数量的祖先信息标记（AIMS；单核苷酸多态性或 SNPS，印度恒河猴和中国恒河猴之间频率差异最大），并在不同比例祖先（在 ¿ 和 ¿ 中国血统之间）的印度/中国杂交恒河猴中对它们进行基因分型，在先前的研究中已对其“气质”测量进行了量化。 通过比较所有染色体上气质“低”与“高”的杂交动物的 SNP 频率，我们将尝试确定恒河猴基因组中影响“气质”的基因位置，这是一种称为“混合作图”的全基因组关联方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to identify a sufficient number of ancestry informative markers (AIMS; single nucleotide polymorphisms, or SNPS, that maximally differ in frequency between Indian and Chinese rhesus macaques) and genotype them in Indian/Chinese hybrid rhesus macaques of varying proportions of ancestry (between ¿ and ¿ Chinese ancestry) for which measures of "temperament" have been quantified in a previous study. By comparing SNP frequencies of hybrid animals with "low" versus "high" temperament across all chromosomes, an attempt will be made to identify locations of genes in the rhesus genome that influence "temperament," a methodology of whole geneome association called "admixture mapping."