ID OF SNPS FOR ADMIXTURE MAPPING OF A QTL FOR TEMPERAMENT IN RHESUS MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是找出足够数量的祖先信息标记(AIMS；单核苷酸多态，SNPs，在印度猕猴和中国猕猴之间频率差异最大的)，并在不同血统(中国和印度血统之间)的印度/中国杂交猕猴中对它们进行基因分型，此前的一项研究已经量化了它们的“气质”测量。通过比较具有“低”和“高”气质的杂交动物在所有染色体上的SNP频率，将试图确定影响“气质”的基因在恒河猴基因组中的位置，这是一种被称为“混合作图”的全基因组关联方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to identify a sufficient number of ancestry informative markers (AIMS; single nucleotide polymorphisms, or SNPS, that maximally differ in frequency between Indian and Chinese rhesus macaques) and genotype them in Indian/Chinese hybrid rhesus macaques of varying proportions of ancestry (between ¿ and ¿ Chinese ancestry) for which measures of "temperament" have been quantified in a previous study. By comparing SNP frequencies of hybrid animals with "low" versus "high" temperament across all chromosomes, an attempt will be made to identify locations of genes in the rhesus genome that influence "temperament," a methodology of whole geneome association called "admixture mapping."