GENETIC MANAGEMENT OF ANIMAL COLONIES

动物群体的遗传管理

• 批准号: 8357271
• 负责人: DAVID Glenn SMITH
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357271
• 关键词: California; Candidate Disease Gene; Funding; Genetic; Genome; Genotype; Grant; Macaca; Macaca mulatta; National Center for Research Resources; Population; Primates; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Services; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; animal colony; base; cost; disease phenotype; genome wide association study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objectives of this project are to 1) identify single nucleotide polymorphisms (SNPs) useful to genetically characterize genetic differences within and among regional populations of rhesus and longtail macaques, 2) identify a panel of SNPs most useful for genetic management, and 3) provide genotyping and genetic management services to NIH investigators based on high throughput genotyping of the SNP panel using the UCD Genome Center. This project will also identify an expanded panel of highly polymorphic SNPs for use in whole genome association studies to detect candidate genes for specific diseases and phenotypes.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的目标是1）确定单核苷酸多态性（SNPs）有用的遗传特性内和恒河猴和长尾猕猴的区域种群之间的遗传差异，2）确定最有用的SNPs的面板遗传管理，和3）提供基因分型和遗传管理服务，以NIH研究人员基于高通量的SNP面板基因分型使用UCD基因组中心。该项目还将确定一个扩展的高度多态性SNP组，用于全基因组关联研究，以检测特定疾病和表型的候选基因。