BETA HAIRPINS OF BRAZZEIN TERMINI

BRAZZEIN TERMINI 的 Beta 发夹

• 批准号: 8361255
• 负责人: FARIBA M ASSADI-PORTER
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361255
• 关键词: Funding; Grant; Human; Modeling; Mutagenesis; National Center for Research Resources; Peptides; Principal Investigator; Research; Research Infrastructure; Resources; Side; Site; Source; United States National Institutes of Health; beta pleated sheet; cost; design; receptor; sweet taste perception

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Combined mutagenesis and modeling results suggest that the termini of brazzein may be the primary brazzein-side interaction site between brazzein and the human sweet taste receptor. The termini of brazzein are involved in an antiparallel beta-sheet, which has allowed us to design beta-hairpin peptides derived from the termini. If the the termini are indeed the primary site of interaction, these peptides derived from the terminal motifs should show at least minimal activity.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 结合的诱变和建模结果表明，Brazzein的末端可能是Brazzein和人类甜味受体之间的主要Brazzein侧相互作用。 Brazzein的末端参与了一个反平行的β-片，这使我们能够设计源自末端的β发肽肽。如果末端确实是相互作用的主要部位，则这些末端基序衍生的肽应至少显示最小的活性。