NMR AND BIOCHEMICAL STUDIES OF BRAZZEIN WITH T1R2/T1R3 HETERORECEPTORS

具有 T1R2/T1R3 异受体的钎焊剂的核磁共振和生化研究

• 批准号: 7954662
• 负责人: FARIBA M ASSADI-PORTER
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954662
• 关键词: Biochemical; Biological; Computer Retrieval of Information on Scientific Projects Database; Fruit; Funding; Grant; Institution; Plants; Proteins; Research; Research Personnel; Resources; Source; South American; Structure; United States National Institutes of Health; insight; mutant; receptor; sweet receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brazzein is a sweet protein found in South American fruit plant Pentadiplatra brazzeana Baillon. The protein interacts with the sweet receptor T1R2-T1R3. To understand their biological significance and interaction with the sweet receptor, we need to understand the structures of sweet brazzein and the non-sweet mutants. This gives insight into their function and help understand interaction with the receptor.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Brazzein 是一种在南美水果植物 Pentadiplatra brazzeana Baillon 中发现的甜味蛋白质。该蛋白与甜味受体 T1R2-T1R3 相互作用。为了了解它们的生物学意义以及与甜味受体的相互作用，我们需要了解甜味Brazzein和非甜味突变体的结构。这可以深入了解它们的功能并有助于理解与受体的相互作用。