EARLY DETECTION OF POLYCYSTIC OVARIAN SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：建立多囊卵巢综合征(PCOS)的首个诊断试验。 多囊卵巢综合征(PCOS)的特征是由于无排卵、雄激素和其他激素的异常分泌以及胰岛素抵抗而导致的不孕。多囊卵巢综合征是最常见的女性内分泌疾病，影响4%至7%的育龄女性，该综合征占所有无排卵的75%。简而言之，多囊卵巢综合征对妇女的生殖健康具有令人震惊的不利生理、心理和经济后果。 我们正在开发一种新的“代谢分析”方法，以检测和统计人体总代谢物池中分子子集的变化，这些分子已被证明是多囊卵巢综合征的可靠早期指标。 该方法将源自威斯康星国家灵长类研究中心对女性和患有多囊卵巢综合征的恒河猴的生物标记物的测量。在过去的二十年里，人们对这些动物进行了很好的描述和研究。这个想法是将多囊卵巢综合征的非人类灵长类模型与人类样本并行使用，以开发一种新的诊断测试。有了这一点，我们将开始分析患者样本，以开发人类多囊卵巢综合征的肖像。我们的方法可以用来为各种其他疾病开发类似的测试。 我们将使用UWMadison独有的技术和资源的组合。我们将使用稳定同位素、核磁共振和质谱学以及先进的数学计算，所有这些都围绕临床和医学科学展开，具有广泛的临床应用。 这项研究使用了WNPRC动物服务中心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To develop the first diagnostic test for PCOS. Polycystic ovary syndrome (PCOS) is marked by infertility due to anovulation, abnormal secretion of androgens and other hormones, and insulin resistance. PCOS is the most common female endocrine disorder, affecting 4 to 7 percent of women in their reproductive years, and the syndrome accounts for 75 percent of all anovulations. In short, PCOS has staggering adverse physiological, psychological and financial consequences for women's reproductive health. We are developing a novel "metabolic analysis" method to detect and statistically model changes in a subset of molecules within the body's total pool of metabolites that have proven to be reliable early indicators of PCOS. The method will derive from measuring biomarkers in women as well as in rhesus monkeys with PCOS at the Wisconsin National Primate Research Center. These animals have been well characterized and studied during the past two decades. The idea is to use a nonhuman primate model of PCOS in parallel with human samples to develop a novel diagnostic test. With this, we will begin to analyze patient samples to develop the portrait of PCOS in humans. Our approach could be used to develop similar tests for a variety of other diseases. We will use a combination of technologies and resources unique to UWMadison. We will use stable isotopes, NMR and mass spectroscopy, and advanced mathematical computation, all of which are centered around clinical and medical sciences with broad clinical applications. This research uses WNPRC Animal Services.