NMR AND BIOCHEMICAL STUDIES OF BRAZZEIN WITH T1R2/T1R3 HETERORECEPTORS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 Brazzein是一种甜蛋白，存在于南美水果植物Pentadiplatra brazzeana Baillon中。该蛋白与甜味受体T1 R2-T1 R3相互作用。为了了解它们的生物学意义以及与甜味受体的相互作用，我们需要了解甜味植物甜蛋白和非甜味突变体的结构。这有助于了解它们的功能，并帮助理解与受体的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Brazzein is a sweet protein found in South American fruit plant Pentadiplatra brazzeana Baillon. The protein intereacts with the sweet repector T1R2-T1R3. To understand their biological significance and interaction with the sweet receptor, we need to understand the structures of sweet brazzein and the non-sweet mutants. This gives insight into their function and help understand interaction with the receptor.