EARLY DETECTION OF POLYCYSTIC OVARIAN SYNDROME

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目的：研制首个多囊卵巢综合征（PCOS）的诊断试验。 多囊卵巢综合征（PCOS）是一种多囊卵巢综合征。 雄激素和其他激素的分泌以及胰岛素抵抗。PCOS是最 常见的女性内分泌失调，影响4%至7%的女性生殖健康。 这种综合征占所有不排卵的75%。总之，PCOS 对妇女的生理、心理和经济造成了惊人的不利后果， 生殖健康。 我们正在开发一种新的“代谢分析”方法， 体内代谢物总池中分子子集的变化， 是PCOS的可靠早期指标。 该方法将从测量女性和恒河猴的生物标志物中获得 威斯康星州国家灵长类动物研究中心。这些动物已经 在过去的二十年里得到了很好的描述和研究。这个想法是用一个非人类的 PCOS的灵长类动物模型与人类样本平行，以开发一种新的诊断测试。 有了这个，我们将开始分析患者样本，以开发人类PCOS的肖像。 我们的方法可以用于开发各种其他疾病的类似测试。 我们将使用UW独有的技术和资源组合麦迪逊。我们将使用 稳定同位素，核磁共振和质谱，以及先进的数学计算，所有的 其以具有广泛临床应用的临床和医学科学为中心。 这项研究使用WNPRC动物服务。 正在编写三份出版物，等待专利申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To develop the first diagnostic test for PCOS. Polycystic ovary syndrome (PCOS) is marked by infertility due to anovulation, abnormal secretion of androgens and other hormones, and insulin resistance. PCOS is the most common female endocrine disorder, affecting 4 to 7 percent of women in their reproductive years, and the syndrome accounts for 75 percent of all anovulations. In short, PCOS has staggering adverse physiological, psychological and financial consequences for women's reproductive health. We are developing a novel "metabolic analysis" method to detect and statistically model changes in a subset of molecules within the body's total pool of metabolites that have proven to be reliable early indicators of PCOS. The method will derive from measuring biomarkers in women as well as in rhesus monkeys with PCOS at the Wisconsin National Primate Research Center. These animals have been well characterized and studied during the past two decades. The idea is to use a nonhuman primate model of PCOS in parallel with human samples to develop a novel diagnostic test. With this, we will begin to analyze patient samples to develop the portrait of PCOS in humans. Our approach could be used to develop similar tests for a variety of other diseases. We will use a combination of technologies and resources unique to UWMadison. We will use stable isotopes, NMR and mass spectroscopy, and advanced mathematical computation, all of which are centered around clinical and medical sciences with broad clinical applications. This research used WNPRC Animal Services. Preparation of three publications are in progress pending patent application.