FTMS STUDIES OF GLYCOSAMINOGLYCANS

糖胺聚糖的 FTMS 研究

• 批准号: 8361791
• 负责人: JAMES H. PRESTEGARD
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361791
• 关键词: Address; Carbohydrates; Cells; Environment; Event; Funding; Glycosaminoglycans; Grant; Mediating; Methods; National Center for Research Resources; Polymers; Principal Investigator; Proteins; Research; Research Infrastructure; Resolution; Resources; Signal Transduction; Source; Surface; United States National Institutes of Health; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Glycosaminoglycans (GAGs) are a structurally very diverse set of carbohydrate polymers found both free and attached to protein at cellular surfaces. They mediate signaling events as well as numerous other interactions between a cell and its environment. Characterizing oligomers derived from these polymers is a challenging problem that can be addressed by high resolution MS methods. New FTMS facilities at the Resource are ideally suited to this research.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 糖胺多聚糖(GAG)是一组结构非常多样化的碳水化合物聚合物，在细胞表面既可以发现游离的，也可以附着在蛋白质上。它们调节信号事件以及细胞与其环境之间的许多其他相互作用。表征由这些聚合物衍生的低聚物是一个具有挑战性的问题，可以通过高分辨率的MS方法来解决。资源中心的新FTMS设施非常适合这项研究。