ALPHA CRYSTALLIN

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 α-晶体蛋白，沿着β-和γ-晶体蛋白，是普遍存在的 脊椎动物晶状体中的晶体蛋白。它是透镜纤维细胞的主要结构成分， 在这些细胞中有伴侣活性在透镜中，它是一种异源寡聚复合物， 两种单体<$A-和<$B-晶体蛋白。我们建议使用cry-EM来解决它的结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alpha-crystallin, along with the beta- and gamma-crystallins, is one of the ubiquitous crystallins in vertebrate lenses. It is a major structural component of lens fiber cells and also has chaperone activity in these cells. In the lens, it is a hetero-oligomeric complex composed of two monomers ¿A- and ¿B-crystallin. We propose to use cry-EM to solve its structure.