UNDERGRADUATE AND MEDICAL STUDENT RESEARCH PROJECTS

本科生和医学生研究项目

• 批准号: 8365519
• 负责人: Catherine E. Costello
• 金额: $ 0.46万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365519
• 关键词: Amyloid Proteins; Biology; Boston; Chemistry; Complex; Devices; Foundations; Funding; Grant; Institution; Investigation; Manuscripts; Mass Spectrum Analysis; Medical; Medical Students; Medicine; National Center for Research Resources; Polysaccharides; Post-Translational Protein Processing; Prealbumin; Principal Investigator; Proteins; Proteomics; Publishing; Research; Research Infrastructure; Research Project Grants; Resources; Source; Students; Testing; Time; United States National Institutes of Health; Universities; Work; base; computer science; cost; falls; forest; medical schools; meetings; posters; programs; resource guides; software development; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Guided by the Resource Directors and staff, students participated in MS Resource research under the Boston University Undergraduate Research Opportunities Program and programs for medical student research in the 2010-2011 academic year. Boston University Chemistry Dept. students make presentations on their work at the annual Undergraduate Research Symposium. Undergraduates from other institutions are also eligible to conduct research at the Resource. Mr. Nikhil Madhusudhan, a chemistry major, joined the Resource in fall 2007. His choice to attend BU was strongly based on the opportunity to perform researdh at the Resource/CPC. He worked on projects that involve electrophoretic protein separation as part of our beta-test of the Protein Forest device and used this device in his investigation of oxidative post-translational modifications of the amyloid protein transthyretin. After his graduation in May 2011, he plans to attend medical school. Mr. Paul Romesser worked under the direction of Resource collaborator Gerald Denis for several years. He was closely involved in proteomics studies of Brd2 complexes. He presented poster on his research at the 2005 Keystone Conference organized by Prof. Costello and Prof. Mann and at the 2007 ASMS meeting. For the summer of 2006, Mr. Romesser received special funding to allow him to work full time at the Resource and CPC. Mr. Romesser began his medical studies at BUSM in Fall 2006 but continued to carry out research at the Resource. A manuscript describing his results was published last year. He interrupted his medical studies to perform two years of research at NIH, under a Howard Hughes Foundation program. He will graduate from BU School of Medicine summa cum laude in May 2011. Prof. Zaia has engaged a group of undergraduate students in the Computer Science program in the project to develop software to support glycan analysis.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在资源总监和工作人员的指导下，学生们在 2010-2011 学年参加了波士顿大学本科生研究机会计划和医学生研究计划下的 MS 资源研究。波士顿大学化学系的学生在年度本科生研究研讨会上介绍他们的工作。其他机构的本科生也有资格在资源中进行研究。 Nikhil Madhusudhan 先生是一名化学专业学生，于 2007 年秋季加入 Resource。他选择加入 BU 很大程度上是基于在 Resource/CPC 进行研究的机会。他参与了涉及电泳蛋白质分离的项目，作为我们蛋白质森林装置 Beta 测试的一部分，并使用该装置研究淀粉样蛋白运甲状腺素蛋白的氧化翻译后修饰。 2011 年 5 月毕业后，他计划就读医学院。 Paul Romesser 先生在 Resource 合作者 Gerald Denis 的指导下工作了数年。他密切参与了 Brd2 复合物的蛋白质组学研究。他在 Costello 教授和 Mann 教授组织的 2005 年 Keystone 会议以及 2007 年 ASMS 会议上展示了他的研究成果。 2006 年夏天，Romesser 先生获得了特别资助，使他能够在 Resource 和 CPC 全职工作。 Romesser 先生于 2006 年秋季开始在 BUSM 进行医学研究，但继续在 Resource 进行研究。去年发表了一份描述他的研究结果的手稿。他中断了医学研究，在霍华德休斯基金会的项目下，在美国国立卫生研究院进行了两年的研究。他将于 2011 年 5 月以优异成绩从 BU 医学院毕业。 Zaia 教授聘请了一组计算机科学专业的本科生参与该项目，开发支持聚糖分析的软件。