Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
生物学和医学质谱资源关闭期间的遗留支持
基本信息
- 批准号:9810729
- 负责人:
- 金额:$ 82.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAreaAutomobile DrivingBacteriaBiologyBiopolymersBostonCardiovascular DiseasesCellsClinicalCommunitiesComplexComplex MixturesComputer softwareDataDatabasesDepositionDevelopmentDiseaseDissociationElectronsEvaluationExtracellular MatrixFosteringFundingFunding AgencyFutureGlycobiologyGlycolipidsGlycosaminoglycansGrantHealthHumanHuman MilkImmunologyIndividualIndustryIndustry CollaborationInfectionInstitutionLinkLipopolysaccharidesMass Spectrum AnalysisMedicineMethodsMissionMonoclonal Antibody R24National Institute of General Medical SciencesParasitesPathway interactionsPeptidesPoliciesPolysaccharidesPostdoctoral FellowProteinsProtocols documentationQuality ControlRequest for ProposalsResearchResourcesScientistStructureTestingTimeTrainingUniversitiesVariantbasebioinformatics tooldesignexperienceion mobilitymass spectrometerprotein misfoldingprotein protein interactionrecruitsoftware developmentstudent trainingtandem mass spectrometrytechnology developmentuser-friendly
项目摘要
The mission of the Boston University Mass Spectrometry Resource for Biology and Medicine is
the development and application of advanced, mass spectrometry-based methods for the
characterization of biopolymers that are relevant to human health and disease. Its steady
progress has been fostered by close working relationships between basic scientists, clinicians
and trainees. Because NIGMS has now imposed a time limit for P41 grants, the grant P41
GM104603 cannot be renewed. This proposal requests the funding essential to avoid a
disruptive sudden closedown of the Resource's activities and afford a smooth transition period
to enable the orderly completion of ongoing driving biomedical and collaborative projects that
depend on methods and expertise uniquely available in the Resource, finalizing of ongoing
software development, sharing of software, databases and protocols to meet the needs of the
community, and the identification and implementation of alternative mechanisms to address the
future needs of the user community and enable further technology developments that should
evolve from the accomplishments of the Resource over the last 20 years. The Resource will
focus on the needs of glycobiology for detailed structural elucidations and the profiling of
complex mixtures of glycans. Reference data that illuminates glycan fragmentation pathways
using multiple dissociation methods will be compiled and deposited into public databases; the
new, user-friendly bioinformatics tools that the Resource is creating for glycan analysis will be
completed, tested and shared. Protocols and sets of reference data for Ion mobility-tandem
mass spectrometry will be compiled for the analysis of glycans and complex peptide mixtures,
for characterization of noncovalent complexes, and for evaluation of new ExD cell designs being
constructed by a small industry collaborator. In-house in developed software for glycan
structural determinations and top-down analysis of variant and post-translationally modified
proteins, that can establish relationships among PTMs on individual proteins, will be completed
and shared; it should provide means for straightforward clinical analyses, and for probing
protein-glycan and protein-protein interactions. Translational projects to be completed will
include characterization of N- and O-linked glycans and lipopolysaccharides on infectious
bacteria and parasites, structural determinations of glycolipids and glycosaminoglycans in
human milk, protein misfolding disorders, immunology, extracellular matrix biology and
cardiovascular disease. The Resource will transfer its experience in training students,
postdoctoral fellows and practicing scientists to other educational institutions and industry.
波士顿大学生物和医学质谱学资源的使命是
先进的、基于质谱学的方法的发展和应用
与人类健康和疾病相关的生物聚合物的特征。它的稳定性
基础科学家、临床医生之间密切的工作关系促进了进步
和实习生。由于NIGMS现在对P41赠款设定了时间限制,因此赠款P41
GM104603不能续订。这项提案要求提供必要的资金,以避免
资源活动的中断性突然关闭并提供平稳的过渡期
能够有序地完成正在进行的推动生物医学和协作的项目
依靠资源中唯一可用的方法和专业知识,最终确定正在进行的
软件开发,共享软件、数据库和协议,以满足
社区,以及确定和实施替代机制,以解决
用户社区的未来需求,并支持进一步的技术开发,
从该资源在过去20年中取得的成就演变而来。资源将
重点关注糖生物学对详细结构阐明的需求和对
多聚糖的复杂混合物。阐明糖链断裂途径的参考数据
使用多种解离方法将被汇编并存入公共数据库;
该资源正在为多糖分析创建的新的、用户友好的生物信息学工具将是
完成、测试和共享。离子移动性的协议和参考数据集.串联
将编制用于分析多糖和复杂多肽混合物的质谱图,
用于表征非共价络合物,并用于评估新的EXD电池设计
由一家小型行业合作者建造。内部开发的葡聚糖软件
变异修饰语和翻译后修饰语的结构确定和自上而下的分析
可以在各个蛋白质上的PTM之间建立联系的蛋白质将被完成
和共享;它应该为直接的临床分析和探测提供手段
蛋白质-多聚糖和蛋白质-蛋白质相互作用。待完成的翻译项目将
包括N-和O-连接多糖和脂多糖的特性
细菌和寄生虫糖脂和糖胺聚糖的结构测定
母乳、蛋白质错误折叠障碍、免疫学、细胞外基质生物学和
心血管疾病。该资源将转移其在培训学生方面的经验,
博士后研究员和实习科学家到其他教育机构和行业。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Catherine E. Costello其他文献
Phencyclidine (Sernylan) poisoning
- DOI:
10.1016/s0022-3476(73)80385-3 - 发表时间:
1973-11-01 - 期刊:
- 影响因子:
- 作者:
William L. Nyhan;Harry C. Shirkey;Craig B. Liden;Frederick H. Lovejoy;Catherine E. Costello - 通讯作者:
Catherine E. Costello
Inactivation of emMinar2/em in mice hyperactivates mTOR signaling and results in obesity
小鼠中 emMinar2/em 的失活过度激活 mTOR 信号并导致肥胖
- DOI:
10.1016/j.molmet.2023.101744 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:6.600
- 作者:
Saran Lotfollahzadeh;Chaoshuang Xia;Razie Amraei;Ning Hua;Konstantin V. Kandror;Stephen R. Farmer;Wenyi Wei;Catherine E. Costello;Vipul Chitalia;Nader Rahimi - 通讯作者:
Nader Rahimi
RETRACTED ARTICLE: Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme
撤回文章:依赖α-酮戊二酸的单核非血红素铁酶形成内过氧化物
- DOI:
10.1038/nature15519 - 发表时间:
2015-11-02 - 期刊:
- 影响因子:48.500
- 作者:
Wupeng Yan;Heng Song;Fuhang Song;Yisong Guo;Cheng-Hsuan Wu;Ampon Sae Her;Yi Pu;Shu Wang;Nathchar Naowarojna;Andrew Weitz;Michael P. Hendrich;Catherine E. Costello;Lixin Zhang;Pinghua Liu;Yan Jessie Zhang - 通讯作者:
Yan Jessie Zhang
若年肥満者における尿中カルボニル物質による血圧上昇の予測
年轻肥胖者尿液中羰基物质导致血压升高的预测
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Garry L. Corthals;Catherine E. Costello;Eric W. Deutsch;Bruno Domon;William Hancock;Fuchu He;Denis Hochstrasser;Gyorgy Marko-Varga;Ghasem Hosseini Salekdeh;Salvatore Sechi;Michael Snyder;Sudhir Srivastava;Mathias Uhlen;Cathy H. Hu;Tadashi Y;佐藤恵美子 - 通讯作者:
佐藤恵美子
emDe novo/em glycan sequencing by electronic excitation dissociation MSsup2/sup-guided MSsup3/sup analysis on an Omnitrap-Orbitrap hybrid instrument
电子激发解离 MS² 引导的 MS³ 分析在 Omnitrap-Orbitrap 混合仪器上进行从头糖链测序
- DOI:
10.1039/d3sc00870c - 发表时间:
2023-06-21 - 期刊:
- 影响因子:7.400
- 作者:
Juan Wei;Dimitris Papanastasiou;Mariangela Kosmopoulou;Athanasios Smyrnakis;Pengyu Hong;Nafisa Tursumamat;Joshua A. Klein;Chaoshuang Xia;Yang Tang;Joseph Zaia;Catherine E. Costello;Cheng Lin - 通讯作者:
Cheng Lin
Catherine E. Costello的其他文献
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{{ truncateString('Catherine E. Costello', 18)}}的其他基金
Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
生物学和医学质谱资源关闭期间的遗留支持
- 批准号:
10204050 - 财政年份:2019
- 资助金额:
$ 82.73万 - 项目类别:
Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
生物学和医学质谱资源关闭期间的遗留支持
- 批准号:
9976561 - 财政年份:2019
- 资助金额:
$ 82.73万 - 项目类别:
MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCH
MALDI-TOF/TOF MS 支持生物医学研究
- 批准号:
8247392 - 财政年份:2012
- 资助金额:
$ 82.73万 - 项目类别:
PROTEIN CYSTEINE POST-TRANSLATIONAL MODIFICATION IN AMYLOIDOSIS
淀粉样变性中的蛋白质半胱氨酸翻译后修饰
- 批准号:
8365496 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
BUSM SEMINARS, LECTURES AND SABBATICAL ON MASS SPECTROMETRY
BUSM 质谱研讨会、讲座和休假
- 批准号:
8365520 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
MICROSCALE SAMPLE PREPARATION FOR MASS SPECTROMETRY
质谱分析的微量样品制备
- 批准号:
8365509 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
OXIDATIVE POST-TRANSLATIONAL MODIFICATIONS IN CARDIOVASCULAR DISEASE
心血管疾病中的氧化翻译后修饰
- 批准号:
8365547 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
ELECTRON TRANSFER DISSOCIATION OF GLYCANS AND GLYCOCONJUGATES
聚糖和糖缀合物的电子转移解离
- 批准号:
8365562 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
LIPID METABOLITES AND PATHWAYS STRATEGY CONSORTIUM
脂质代谢物和途径策略联盟
- 批准号:
8365525 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
LC-MSN METHOD FOR QUALITATIVE & QUANTITATIVE ANALYSIS OF COMPLEX LIPID MIXTURES
LC-MSN 定性方法
- 批准号:
8365492 - 财政年份:2011
- 资助金额:
$ 82.73万 - 项目类别:
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