Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine

生物学和医学质谱资源关闭期间的遗留支持

基本信息

  • 批准号:
    9810729
  • 负责人:
  • 金额:
    $ 82.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-01 至 2022-06-30
  • 项目状态:
    已结题

项目摘要

The mission of the Boston University Mass Spectrometry Resource for Biology and Medicine is the development and application of advanced, mass spectrometry-based methods for the characterization of biopolymers that are relevant to human health and disease. Its steady progress has been fostered by close working relationships between basic scientists, clinicians and trainees. Because NIGMS has now imposed a time limit for P41 grants, the grant P41 GM104603 cannot be renewed. This proposal requests the funding essential to avoid a disruptive sudden closedown of the Resource's activities and afford a smooth transition period to enable the orderly completion of ongoing driving biomedical and collaborative projects that depend on methods and expertise uniquely available in the Resource, finalizing of ongoing software development, sharing of software, databases and protocols to meet the needs of the community, and the identification and implementation of alternative mechanisms to address the future needs of the user community and enable further technology developments that should evolve from the accomplishments of the Resource over the last 20 years. The Resource will focus on the needs of glycobiology for detailed structural elucidations and the profiling of complex mixtures of glycans. Reference data that illuminates glycan fragmentation pathways using multiple dissociation methods will be compiled and deposited into public databases; the new, user-friendly bioinformatics tools that the Resource is creating for glycan analysis will be completed, tested and shared. Protocols and sets of reference data for Ion mobility-tandem mass spectrometry will be compiled for the analysis of glycans and complex peptide mixtures, for characterization of noncovalent complexes, and for evaluation of new ExD cell designs being constructed by a small industry collaborator. In-house in developed software for glycan structural determinations and top-down analysis of variant and post-translationally modified proteins, that can establish relationships among PTMs on individual proteins, will be completed and shared; it should provide means for straightforward clinical analyses, and for probing protein-glycan and protein-protein interactions. Translational projects to be completed will include characterization of N- and O-linked glycans and lipopolysaccharides on infectious bacteria and parasites, structural determinations of glycolipids and glycosaminoglycans in human milk, protein misfolding disorders, immunology, extracellular matrix biology and cardiovascular disease. The Resource will transfer its experience in training students, postdoctoral fellows and practicing scientists to other educational institutions and industry.
波士顿大学生物和医学质谱资源的任务是

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Catherine E. Costello其他文献

Phencyclidine (Sernylan) poisoning
  • DOI:
    10.1016/s0022-3476(73)80385-3
  • 发表时间:
    1973-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    William L. Nyhan;Harry C. Shirkey;Craig B. Liden;Frederick H. Lovejoy;Catherine E. Costello
  • 通讯作者:
    Catherine E. Costello
Inactivation of emMinar2/em in mice hyperactivates mTOR signaling and results in obesity
小鼠中 emMinar2/em 的失活过度激活 mTOR 信号并导致肥胖
  • DOI:
    10.1016/j.molmet.2023.101744
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
    6.600
  • 作者:
    Saran Lotfollahzadeh;Chaoshuang Xia;Razie Amraei;Ning Hua;Konstantin V. Kandror;Stephen R. Farmer;Wenyi Wei;Catherine E. Costello;Vipul Chitalia;Nader Rahimi
  • 通讯作者:
    Nader Rahimi
RETRACTED ARTICLE: Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme
撤回文章:依赖α-酮戊二酸的单核非血红素铁酶形成内过氧化物
  • DOI:
    10.1038/nature15519
  • 发表时间:
    2015-11-02
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Wupeng Yan;Heng Song;Fuhang Song;Yisong Guo;Cheng-Hsuan Wu;Ampon Sae Her;Yi Pu;Shu Wang;Nathchar Naowarojna;Andrew Weitz;Michael P. Hendrich;Catherine E. Costello;Lixin Zhang;Pinghua Liu;Yan Jessie Zhang
  • 通讯作者:
    Yan Jessie Zhang
若年肥満者における尿中カルボニル物質による血圧上昇の予測
年轻肥胖者尿液中羰基物质导致血压升高的预测
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Garry L. Corthals;Catherine E. Costello;Eric W. Deutsch;Bruno Domon;William Hancock;Fuchu He;Denis Hochstrasser;Gyorgy Marko-Varga;Ghasem Hosseini Salekdeh;Salvatore Sechi;Michael Snyder;Sudhir Srivastava;Mathias Uhlen;Cathy H. Hu;Tadashi Y;佐藤恵美子
  • 通讯作者:
    佐藤恵美子
emDe novo/em glycan sequencing by electronic excitation dissociation MSsup2/sup-guided MSsup3/sup analysis on an Omnitrap-Orbitrap hybrid instrument
电子激发解离 MS² 引导的 MS³ 分析在 Omnitrap-Orbitrap 混合仪器上进行从头糖链测序
  • DOI:
    10.1039/d3sc00870c
  • 发表时间:
    2023-06-21
  • 期刊:
  • 影响因子:
    7.400
  • 作者:
    Juan Wei;Dimitris Papanastasiou;Mariangela Kosmopoulou;Athanasios Smyrnakis;Pengyu Hong;Nafisa Tursumamat;Joshua A. Klein;Chaoshuang Xia;Yang Tang;Joseph Zaia;Catherine E. Costello;Cheng Lin
  • 通讯作者:
    Cheng Lin

Catherine E. Costello的其他文献

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{{ truncateString('Catherine E. Costello', 18)}}的其他基金

Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
生物学和医学质谱资源关闭期间的遗留支持
  • 批准号:
    10204050
  • 财政年份:
    2019
  • 资助金额:
    $ 82.73万
  • 项目类别:
Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
生物学和医学质谱资源关闭期间的遗留支持
  • 批准号:
    9976561
  • 财政年份:
    2019
  • 资助金额:
    $ 82.73万
  • 项目类别:
MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCH
MALDI-TOF/TOF MS 支持生物医学研究
  • 批准号:
    8247392
  • 财政年份:
    2012
  • 资助金额:
    $ 82.73万
  • 项目类别:
PROTEIN CYSTEINE POST-TRANSLATIONAL MODIFICATION IN AMYLOIDOSIS
淀粉样变性中的蛋白质半胱氨酸翻译后修饰
  • 批准号:
    8365496
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:
BUSM SEMINARS, LECTURES AND SABBATICAL ON MASS SPECTROMETRY
BUSM 质谱研讨会、讲座和休假
  • 批准号:
    8365520
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:
MICROSCALE SAMPLE PREPARATION FOR MASS SPECTROMETRY
质谱分析的微量样品制备
  • 批准号:
    8365509
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:
OXIDATIVE POST-TRANSLATIONAL MODIFICATIONS IN CARDIOVASCULAR DISEASE
心血管疾病中的氧化翻译后修饰
  • 批准号:
    8365547
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:
ELECTRON TRANSFER DISSOCIATION OF GLYCANS AND GLYCOCONJUGATES
聚糖和糖缀合物的电子转移解离
  • 批准号:
    8365562
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:
LIPID METABOLITES AND PATHWAYS STRATEGY CONSORTIUM
脂质代谢物和途径策略联盟
  • 批准号:
    8365525
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:
LC-MSN METHOD FOR QUALITATIVE & QUANTITATIVE ANALYSIS OF COMPLEX LIPID MIXTURES
LC-MSN 定性方法
  • 批准号:
    8365492
  • 财政年份:
    2011
  • 资助金额:
    $ 82.73万
  • 项目类别:

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