LIPID METABOLITES AND PATHWAYS STRATEGY CONSORTIUM

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目得到了NIGMS胶水赠款的支持。整个计划有以下目标：(1)分离和检测特定细胞中的所有脂类，并发现和表征可能存在的任何新的脂类。(2)对存在的每种脂代谢产物进行定量，并对其在细胞功能过程中的水平和位置的变化进行定量。(3)定义每种脂类的生化途径，并开发定义相互作用网络的脂类图谱。为了帮助中性脂质核心，脂质组学重点领域，由R.C.墨菲，大学。在科罗拉多州健康科学中心，BUSM MS资源协助确定新型中性脂质的结构。C.E.Costello为LipidMaps计划提供脂类的质谱分析新方法方面的专业知识，并参加LipidMaps调查人员的年度会议。她在2010年5月的Lipid Maps调查员会议上做了一次受邀演讲。与博士后朴惠贞共同撰写的帖子已被接受在2011年5月的会议上展示。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is supported by an NIGMS Glue Grant. The overall program has the following objectives: (1) Separate and detect all of the lipids in a specific cell and discover and characterize any novel lipids that may be present. (2) Quantitate each of the lipid metabolites present and quantitate the changes in their levels and location during cellular function. (3) Define the biochemical pathways for each lipid and develop lipid maps which define the interaction networks. To aid the Neutral Lipids Core, Lipidomics Focus Area, directed by R.C. Murphy, Univ. Colorado Health Sciences Center, the BUSM MS Resource assists in the structural determinations of novel neutral lipids. C. E. Costello provides expertise on new methods for mass spectral analysis of lipids to the Lipid MAPS program and attends the annual meeting of LipidMaps investigators. She presented an invited lecture at the May 2010 meeting of Lipid Maps investigators. A posted coauthored with postdoctoral fellow Hyejung Park has been accepted for presentation at the May 2011 meeting.