ADIABATIC MAGNETIZATION PREPARATION PULSE FOR T2-CONTRAST AT 7 TESLA

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 7 T的高分辨率MRI有可能在广泛的疾病诊断和治疗方面提供巨大的改善。 一系列神经系统疾病。 高分辨率T2加权序列是评价隐蔽构造的敏感方法 与许多疾病相关的异常[1]。 不幸的是，传统的T2加权序列，如 快速旋转回波（FSE），利用一系列高翻转角Shinnar Le-Roux（SLR）[2]重新聚焦脉冲，这些脉冲非常敏感 在7 T下观察到的严重B1不均匀性和SAR限制。 我们提出了一种替代绝热磁化 制备（AMP）技术以在7 T下获得B1不敏感的T2对比度。 BIR-4脉冲[3，4]，翻转角为0？， 在段之间插入的延迟用于引入T2衰减。 AMP脉冲被设计为在7 T下使用并得到验证 和体内实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High-resolution MRI at 7T has the potential to provide tremendous improvement in the diagnosis and treatment of a wide range of neurological diseases. High-resolution T2-weighted sequences are sensitive for assessing subtle structural abnormalities associated with many of these diseases [1]. Unfortunately, conventional T2-weighted sequences, such as Fast Spin Echo (FSE), utilize a train of high flip-angle Shinnar Le-Roux (SLR) [2] refocusing pulses that are very susceptible to the severe B1 inhomogeneity and SAR limitations observed at 7T. We propose an alternative adiabatic magnetization preparation (AMP) technique to obtain B1-insensitive T2-contrast at 7T. A BIR-4 pulse [3,4] with a flip angle of 0¿ with delays inserted between segments is used to introduce T2 decay. An AMP pulse was designed for use at 7T and validated with phantom and in vivo experiments.