IMPROVING DSC-MRI BY ORIENTATION-CORRECTED PHASE-BASED AIF AND VOF

通过基于相位校正的 AIF 和 VOF 改进 DSC-MRI

• 批准号: 8362926
• 负责人: MATUS STRAKA
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362926
• 关键词: Annual Reports; Blood Vessels; Data; Frequencies; Funding; Grant; Image; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; National Center for Research Resources; Perfusion; Phase; Predisposition; Principal Investigator; Reading; Relative (related person); Research; Research Infrastructure; Resources; Scanning; Signal Transduction; Source; Technology; Tracer; United States National Institutes of Health; Visit; abstracting; base; cost; human AMID protein; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Quantitative DSC-MRI perfusion imaging requires signal values that can be accurately converted to tracer concentration values but measuring vascular concentration (e.g. arterial input function AIF) remains challenging. Susceptibility agents induce a change in the resonance frequency that is linear with the tracer concentration and does not depend on T1. This change in frequency can be assessed by change in MR signal phase and could potentially deliver better estimates of tracer concentration. The observable phase effect depends however on the orientation of the vessels relative B0 (Eq. 1) and information about vessel orientation is thus warranted. To avoid extra cumbersome measurements we propose to estimate the vessel orientation from the magnitude data of the dynamic EPI scan itself. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 定量DSC-MRI灌注成像需要能够准确转换为示踪剂浓度的信号值 但测量血管浓度(例如动脉输入功能AIF)仍然具有挑战性。敏感剂 诱导共振频率的变化，该变化与示踪剂浓度呈线性关系，而不依赖于T1。这 频率的变化可以通过磁共振信号相位的变化来评估，并可能提供更好的示踪剂估计 集中精神。然而，可观察到的相位效应取决于血管相对B0的取向(等式)。1)和 因此，有关船只朝向的信息是有根据的。为了避免额外繁琐的测量，我们建议估计 根据动态EPI扫描本身的幅度数据来确定血管方向。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/(卢卡斯年度报告和 ISMRM 2011年摘要)