STRUCTURE FUNCTION RELATIONSHIPS IN POLYSACCHARIDES & POLYSACCHARIDE-BLENDS

多糖的结构功能关系

• 批准号: 8361312
• 负责人: SRINIVAS JANASWAMY
• 金额: $ 1.18万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361312
• 关键词: Ascorbic Acid; Behavior; Biophysics; Biopolymers; Carrageenan; Curcumin; Development; Differential Scanning Calorimetry; Drug vehicle; Encapsulated; Fiber; Food; Funding; Grant; Hydrocolloid; National Center for Research Resources; Nutraceutical; Pharmaceutical Preparations; Polysaccharides; Principal Investigator; Research; Research Infrastructure; Resources; Rheology; Source; Structure-Activity Relationship; United States National Institutes of Health; Vitamins; controlled release; cost; design; iota Carrageenan; novel; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The main focus this proposal is about understanding the structural behavior of biopolymers leading to the design of new materials as well as utilizing the polysaccharide fibers as control delivery vehicles of Drug molecules, Nutraceutical and Vitamins. We have successfully encapsulated several drug molecules, Curcumin (nutraceutical) and Vitamin- C in the iota-carrageenan fibers and demonstrated the packing changes in the iota-carrageenan network upon the small molecule incorporation. These results are further corroborated by Rheology, Differential Scanning Calorimetry studies as well as control release of drug molecule from the carrageenan network. These preliminary results clearly suggest the development of novel and controlled delivery carriers using food hydrocolloids.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该提案的主要重点是了解生物聚合物的结构行为，从而设计新材料，并利用多糖纤维作为药物分子，营养品和维生素的控制递送载体。我们已经成功地将几种药物分子、姜黄素（营养品）和维生素C包封在I-角叉菜胶纤维中，并证明了在小分子掺入后I-角叉菜胶网络中的堆积变化。流变学、差示扫描量热法研究以及药物分子从角叉菜胶网络中的控制释放进一步证实了这些结果。这些初步结果清楚地表明，使用食品水胶体的新型和控制输送载体的发展。