STRUCTURE FUNCTION RELATIONSHIPS IN POLYSACCHARIDES

多糖的结构功能关系

• 批准号: 8171984
• 负责人: SRINIVAS JANASWAMY
• 金额: $ 0.36万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171984
• 关键词: Architecture; Biopolymers; Computer Retrieval of Information on Scientific Projects Database; Development; Drug Interactions; Exhibits; FDA approved; Food; Funding; Grant; Institution; Knowledge; Life; Molecular; Names; Organism; Pharmaceutical Preparations; Polysaccharides; Property; Research; Research Personnel; Resources; Sampling; Solutions; Solvents; Source; Structure; Structure-Activity Relationship; System; Texture; United States National Institutes of Health; Vertebral column; Viscosity; Vitamins; Water; Wood material; analog; controlled release; galactoglucomannan; gellan; improved; insight; iota Carrageenan; lambda Carrageenan; novel; small molecule; solute; triple helix

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polysaccharides comprise a distinct class of biopolymers produced universally among the living organisms. They exhibit a wide variety of unique structures leading to sheets and spirals of single, double and triple helices. Many polysaccharides are water soluble and are capable of significantly altering the solution properties such as texture, gelation and viscosity, to name a few. In this regard, insights about of polysaccharides architecture aid in understanding and predicting their functionality. Hence, elucidation of polysaccharide structures and their interactions with solvent and solute molecules as well as the synergistic interactions in mixed polysaccharide systems provides insights about their structure-function relationships towards developing biopolymers with improved functionality. In this regard, the current proposal is about determining the molecular architecture of a number of biologically important and industrially useful polysaccharides. The study includes the samples from algal (iota, kappa and lambda carrageenans); bacterial (gellan analog and cepacian); wood (galactoglucomannan) and binary system (acetan: glucomannan, corn arabinoxylan: glucomannan). Further, our recent research demonstrates that several drug molecules, nutraceuticals or vitamins can be embedded in the crystalline iota-carrageenan network leading to novel polymeric cocrystals. In order to gain knowledge about the intrinsic interactions between the small molecules with the polysaccharide backbone, so as to understanding the release profile of the small molecules, our second aim is centered on structural characterization of several polymeric cocrystals utilizing FDA approved food polysaccharides combined with small drug molecules as well as nutraceuticals. It is hoped that these results would be helpful in understanding the polysaccharide:drug interactions towards the development of controlled release vehicles.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多糖包括在活生物体中普遍产生的独特类别的生物聚合物。它们表现出各种各样的独特结构，导致单，双和三螺旋的片和螺旋。许多多糖是水溶性的，并且能够显著改变溶液性质，例如质地、凝胶化和粘度，仅举几例。在这方面，关于多糖结构的见解有助于理解和预测其功能。因此，阐明多糖结构及其与溶剂和溶质分子的相互作用以及混合多糖系统中的协同相互作用，为开发具有改进功能的生物聚合物提供了关于其结构-功能关系的见解。在这方面，目前的建议是关于确定一些生物学上重要的和工业上有用的多糖的分子结构。本研究包括来自藻类（ι、κ和λ角叉菜胶）、细菌（结冷胶类似物和洋葱）、木材（半乳葡甘露聚糖）和二元体系（丙酮：葡甘露聚糖、玉米阿拉伯木聚糖：葡甘露聚糖）的样品。此外，我们最近的研究表明，几种药物分子，营养品或维生素可以嵌入到结晶I-角叉菜胶网络中，导致新的聚合物共晶。为了获得关于小分子与多糖骨架之间的内在相互作用的知识，以便理解小分子的释放曲线，我们的第二个目标是集中于利用FDA批准的食品多糖与小药物分子以及营养品组合的几种聚合物共晶的结构表征。希望这些结果有助于了解多糖：药物相互作用对控制释放载体的发展。