THE YEAST KINETOCHORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 有丝分裂是细胞分裂过程中重复染色体分离的基本过程。 这一过程中的错误导致非整倍体，这与癌症、出生缺陷和细胞死亡有关。 在有丝分裂过程中，姐妹染色单体被从两个相对的纺锤体两极发出的微管物理上分开。 微管通过动粒附着在染色体上。 动粒是一种大型蛋白质组装体，参与染色体运动的结构和调控。 这些作用对于准确的细胞分裂至关重要，因为几种动粒组分在癌细胞中过表达。 我们的目标是揭示动粒是如何确保子细胞忠实地接受完整的遗传物质的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mitosis is the fundamental process by which duplicated chromosomes are segregated during cell division. Errors in this process result in aneuploidy, which is implicated in cancer, birth defects and cell death. During mitosis, sister chromatids are physically separated by microtubules emanating from two opposing spindle poles. Microtubules attach to chromosomes via the kinetochore. Kinetochores are large protein assemblies involved in both structural and regulatory aspects of chromosome movement. These roles are central to accurate cell division, as several kinetochore components are overexpressed in cancer cells. Our goal is to uncover how kinetochores ensure that daughter cells faithfully receive their full complement of genetic material.