THE YEAST KINETOCHORE
THE YEAST KINETOCHORE
批准号:
8365900
负责人:
Tracy Davis
金额:
$2.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-01 至 2012-06-30
关键词:
AneuploidyBiologyCell DeathCell divisionChromosomesComplementCongenital AbnormalityEnsureFundingFungal GenomeGenetic MaterialsGoalsGrantKinetochoresMalignant NeoplasmsMicrotubulesMitosisNational Center for Research ResourcesPrincipal InvestigatorProcessProteinsResearchResearch InfrastructureResourcesRoleSister ChromatidSourceUnited States National Institutes of Healthcancer cellchromosome movementcostdaughter celloverexpression
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Mitosis is the fundamental process by which duplicated chromosomes are segregated during cell division. Errors in this process result in aneuploidy, which is implicated in cancer, birth defects and cell death. During mitosis, sister chromatids are physically separated by microtubules emanating from two opposing spindle poles. Microtubules attach to chromosomes via the kinetochore. Kinetochores are large protein assemblies involved in both structural and regulatory aspects of chromosome movement. These roles are central to accurate cell division, as several kinetochore components are overexpressed in cancer cells. Our goal is to uncover how kinetochores ensure that daughter cells faithfully receive their full complement of genetic material.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SUBCOMPLEXES OF THE SPINDLE POLE BODY
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批准号:8365892
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项目类别:
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资助金额:$1.28万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
MPS1P PHOSPHORYLATION OF DAM1P
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批准号:8365893
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项目类别:
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资助金额:$1.28万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
YRC PEPTIPEDIA
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批准号:8365873
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项目类别:
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资助金额:$5.42万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
PREPARATION OF THE YEAST RESOURCE CENTER PROGRESS REPORT
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批准号:8365874
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项目类别:
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资助金额:$4.82万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
ADMINISTRATION OF THE YEAST RESOURCE CENTER
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批准号:8365923
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项目类别:
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资助金额:$6.12万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
REDESIGN AND REPROGRAMMING OF THE YEAST RESOURCE CENTER'S PRIMARY WEB SITE
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批准号:8365882
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项目类别:
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资助金额:$0.99万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
DEVELOPMENT OF A WEB-BASED INFORMATICS PLATFORM
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批准号:8365881
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项目类别:
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资助金额:$2.33万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
YEAST RESOURCE CENTER PUBLIC DATA REPOSITORY
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批准号:8365875
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项目类别:
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资助金额:$2.33万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
SEMINARS GIVEN BY TRISHA N DAVIS
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批准号:8365926
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项目类别:
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资助金额:$0.99万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
YRC PUBLIC IMAGE REPOSITORY (YRC PIR)
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批准号:8365916
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项目类别:
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资助金额:$10.41万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
ISOTOPE SIGNATURE BASED IDENTIFICATION OF CROSSLINKED PEPTIDES BY MS
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批准号:8365802
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项目类别:
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资助金额:$2.95万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
TRAINING IN MICROSCOPY
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批准号:8365925
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项目类别:
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资助金额:$0.99万
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财政年份:2011
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负责人:Tracy Davis
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依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位: