THE YEAST KINETOCHORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 有丝分裂是细胞分裂过程中分离复制染色体的基本过程。这个过程中的错误会导致非整倍体，这与癌症、出生缺陷和细胞死亡有关。在有丝分裂过程中，姐妹染色单体由两个相对的纺锤体极发出的微管在物理上分开。微管通过着丝粒附着在染色体上。动点是涉及染色体运动的结构和调控两个方面的大型蛋白质组合。这些作用是细胞准确分裂的中心，因为几个动粒成分在癌细胞中过度表达。我们的目标是揭示动点是如何确保子代细胞忠实地获得全部遗传物质的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mitosis is the fundamental process by which duplicated chromosomes are segregated during cell division. Errors in this process result in aneuploidy, which is implicated in cancer, birth defects and cell death. During mitosis, sister chromatids are physically separated by microtubules emanating from two opposing spindle poles. Microtubules attach to chromosomes via the kinetochore. Kinetochores are large protein assemblies involved in both structural and regulatory aspects of chromosome movement. These roles are central to accurate cell division, as several kinetochore components are overexpressed in cancer cells. Our goal is to uncover how kinetochores ensure that daughter cells faithfully receive their full complement of genetic material.