Chemical biology investigation of cell death processes: development of molecular probes interfering with necroptosis

点击翻译按钮获取中文摘要

Necroptotic programmed cell death has a key role in maintaining healthy tissue, and dysregulation of this process is associated with the pathology of infection and a range of chronic inflammation diseases for which there are few satisfactory treatments. In this project, we will discover small, drug like, molecules that interfere with the necroptosis pathway. These small molecules have the potential to become new therapeutics to treat these inflammatory diseases and will be invaluable probes to study this key biological pathway.