MODIFICATION OF BUTYRYLCHOLINESTERASE BY ORGANOPHOPHOUS COMPOUNDS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 丁酰胆碱酯酶(BCHE)，或血清胆碱酯酶，是一种非特异性胆碱酯酶 发现于血浆中可分解胆碱酯的物质。这个项目需要寻找 苯基沙利精等有机磷化合物对BCHE的修饰 磷酸盐(PSP)和2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide(CBDP)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Butyrylcholinesterase (BCHE), or serum cholinesterase, is a non-specific cholinesterase found in blood plasma that hydrolyses choline esters. This project entails the search for modifications of BCHE by organophosphorous compounds such as phenyl saligenin phosphate (PSP) and 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP).