ACR Basic Research Conference

描述(由申请人提供)：十多年来，ACR一直是推动风湿病科学家和研究人员之间双向交流尖端科学信息的领导者，通过其年度基础研究会议，这是ACR年会之前在会议地点举行的科学研讨会。年会通常吸引超过10,000人参加，是就研究、教育、患者护理和社会经济问题提供交流意见的主要机制。它也是传播当前与风湿性疾病相关的基础研究成果的主要形式。为了强调风湿和肌肉骨骼疾病发病机制所依据的基础科学原理，ACR在年会中建立了强调基础科学的具体计划。五个拟议会议中的第一个将与2010年在佐治亚州亚特兰大举行的ACR年度科学会议一起举行，主题将是自身免疫中的B细胞：从抗体到免疫调节。这将是一次最先进的会议，来自美国和国外的著名科学家组成的小组将讨论B淋巴细胞(B细胞)的生物学，重点是它们在炎症和自身免疫中的作用。会议由世界著名的B细胞生物学家Ann Marshak-Rothstein博士(医学教授)和E.William St.Clair博士(医学教授)组织，Ann Marshak-Rothstein博士是世界著名的B细胞生物学家，最近被招募到马萨诸塞大学医学中心风湿科；E.William St.Clair博士是杜克大学风湿病主任，也是杜克大学自身免疫卓越中心的首席研究员，是免疫耐受网络临床事务的副主任，是B细胞和自身免疫病方面的专家。为随后的四次会议选定了主题：2011年将重点讨论骨重建的调控，骨病理是许多风湿病的共同方面，是许多治疗的结果。已经选定了2012-2014年的暂定主题清单，(1)间充质细胞和基质生物学：风湿性疾病中的迁移、侵袭和纤维化。(2)风湿病先天免疫与获得性免疫之间的界面。(3)非编码RNA在免疫调节性疾病发病机制中的作用；(4)类风湿性疾病中的脂质介质；(5)免疫介导性炎症性疾病中的细胞应激反应；(6)树突状细胞在耐受和自身免疫调节中的作用。

DESCRIPTION (provided by applicant): For over a decade the ACR has been a leader in the effort to facilitate the bidirectional exchange of cutting edge scientific information between scientists and investigators in rheumatic diseases through its annual Basic Research Conference, a scientific symposium that occurs immediately prior to the ACR Annual Meeting at the site of the meeting. The Annual Meeting, which typically attracts more than 10,000 attendees, is the principal mechanism for providing a forum for the exchange of ideas about research, education, patient care and socioeconomic issues. It is also the primary format for disseminating the current basic research findings relevant to rheumatic disorders. In order to emphasize the principles of basic science that underlie the pathogenesis of rheumatic and musculoskeletal diseases, the ACR has built specific programs emphasizing basic science into the Annual Meeting. The topic for the first of the five proposed conferences, to be held in conjunction with the 2010 ACR Annual Scientific Meeting in Atlanta, Georgia, will be B Cells in Autoimmunity: From Antibodies to Immunoregulation. This will be a state-of-the-art conference featuring a prestigious panel of outstanding scientists from the US and abroad to discuss the biology of B-lymphocytes (B-cells) with a focus on their role in inflammation and autoimmunity. The meeting has been organized by Dr. Ann Marshak-Rothstein (Professor of Medicine), a world-renowned B-cell biologist who was recently recruited to the Section of Rheumatology at the University of Massachusetts Medical Center, and Dr. E. William St. Clair (Professor of Medicine), Chief of Rheumatology at Duke University who is also the principal investigator for the Autoimmunity Center of Excellence at Duke and is the Deputy Director of Clinical Affairs for the Immune Tolerance Network and is an expert on B-cells and autoimmune disease. Topics have been chosen for the four subsequent conferences: 2011 will focus on regulation of bone remodeling, bone pathology is a common facet of many rheumatic diseases and occurs as a consequence of many treatments. A list of tentative topics has been chosen for 2012-2014, (1) mesenchymal cells and matrix biology: migration, invasion and fibrosis in rheumatic diseases. (2) the interface between innate and adaptive immunity in rheumatic disease. (3) non-coding RNA in immunoregulation disease pathogenesis, (4) lipid mediators in rheumatic disease, (5) the cellular stress response in immune-mediated inflammatory disease, and (6) dendritic cells in the regulation of tolerance and autoimmunity.