Reducing Social Disparities in Cancer Risk: The Role of Work and Worker Health

描述(由申请人提供)：此申请是对目前资助的K05癌症预防、控制、行为和人口科学科学研究人员奖的竞争性续签。我是哈佛大学公共卫生学院的社会、人类发展和健康教授，也是达纳-法伯社区研究中心的主任。我将继续把我50%的精力投入到K05，并将这一努力平均分配给我的研究(25%)和指导(25%)。这项申请证明了迄今为止该奖项对癌症预防和控制的重大贡献。 我的研究的核心是基于工作场所的随机研究，这些研究测试针对个人和组织变革的理论驱动的干预措施的有效性，特别是关注低收入、多种族的工作人口。这项研究的一个主题是测试嵌入到人们生活和工作的社会背景中的行为干预的有效性。K05的资金大大增加了我在阐明国家工作场所卫生研究议程方面所能提供的领导能力，并扩大了我的合作基础。有了这个奖项，我能够为健康行为改变的社会背景模式的作用提供证据，包括通过与博士后研究员和学生的合作和指导，以及通过新资助的研究。它还使我有可能通过提供受保护的时间和资源来建立印度工地癌症预防研究的基础，以建立密切的合作，为这一新的研究路线获得资金，并培养在不同文化背景下工作的技能。 K05的续订将为实现我的职业目标提供支持：通过更好地了解工作的社会和物理背景及其现场干预的潜在影响，为减少美国和国外癌症风险的差异做出重大贡献。这一K05将有助于建立我对工作和工作经验在工人健康结果中的作用的理解，特别是与癌症风险相关的行为。我将利用这种对工作的社会和物理环境的作用的理解来提高全面工作场所癌症预防干预的有效性，特别是对高风险工人的干预。我还打算将这项工作应用于印度的工作场所，以便了解地方和文化在旨在减少癌症风险相关行为的干预措施中所起的作用。这一K05还将有助于我对工作场所采用和实施有效干预措施的过程进行研究，以扩大传播努力的范围和有效性。 我通过K05实现的目标不能通过其他机制来实现，包括我目前的R01的S。K05提供了一个机会来综合不同工地环境中的研究结果，确定交叉主题，并研究这些研究结果在工地政策、实践和计划中的应用。尽管我的研究组合资金充足，但这些单独的项目并没有提供机制来探索共同的主题和跨研究的反馈循环。这次K05还将使我能够扩大我对工作场所组织实践、影响工作场所健康的政策以及市场上工作场所健康促进和健康保护的组织的知识；为合成和撰写关于横向主题和实践影响的文章提供受保护的时间；并为我在印度的研究扩大我的技能。 我渴望通过这个奖项扩大指导的范围。我将投入25%的精力为初级教师、博士后研究员和博士生提供指导，目的是让他们为旨在减少癌症风险差异的研究做出重大而有意义的贡献，并越来越多地将重点放在工作场所的癌症预防研究上。我还将围绕卓越的指导扩大我的领导能力，以增加其他高级调查人员对指导的重视。此外，我希望在印度和其他发展中国家的癌症预防研究人员中指导和建设研究能力。 我在达纳-法伯癌症研究所和哈佛大学公共卫生学院的机构之家表现出了对这份K05所包括的工作的杰出承诺。这些机构中的每一个都为我的研究和指导活动提供了大量的资源和机会。

DESCRIPTION (provided by applicant): This application is a competitive renewal for a currently funded K05, Established Scientific Investigator Award in Cancer Prevention, Control, Behavioral, and Population Sciences. I am a Professor of Society, Human Development and Health in the Harvard School of Public Health and the Director of the Dana-Farber's Center for Community-Based Research. I will continue to devote 50% of my effort to this K05, and will split this effort evenly between my research (25%) and mentoring (25%). This application demonstrates the significant contributions to cancer prevention and control resulting from this award to date. The core of my research is randomized worksite-based studies that test the effectiveness of theory-driven interventions targeting individual and organizational change, focusing particularly on low-income, multi-ethnic working populations. A theme of this research is to test the efficacy of behavioral interventions that are embedded in the social context in which people live and work. Funding of the K05 has significantly increased the leadership I have been able to provide in articulating a national worksite health research agenda and has expanded the base of my collaborations. With this award, I have been able to provide evidence for the role of the social contextual model of health behavior change, including through collaborations and mentoring with post-doctoral fellows and students and through newly funded research. It has also made it possible for me to establish a foundation for worksite cancer prevention research in India by providing protected time and resources to build close collaborations, obtain funding for this new line of research, and develop skills for working in a different cultural context. The renewal of this K05 will provide support for meeting my career goal: to make significant contributions to reductions in disparities in cancer risk, in the US and abroad, through improved understanding of the social and physical context of work and its potential impact of worksite interventions. This K05 will contribute to building my understanding of the role of work and job experiences in worker health outcomes, particularly cancer risk-related behaviors. I will apply this understanding of the role of the social and physical context of work to improve the efficacy of comprehensive worksite cancer prevention interventions, particularly for workers at elevated risk. I also aim to adapt this work to worksites in India, in order to understand the role of place and culture in interventions aimed at reducing cancer risk-related behaviors. This K05 will also facilitate my research on the process of worksite adoption and implementation of effective interventions, in order to extend the reach and effectiveness of dissemination efforts. What I aim to accomplish through this K05 cannot be accomplished through other mechanisms, including my current R01's. The K05 provides the opportunity to synthesize research findings across studies in various worksite settings, identify cross-cutting themes, and study the application of these findings to worksite policies, practices, and programs. Although my research portfolio is well-funded, these individual projects do not provide mechanisms to explore shared themes and feedback loops across studies. This K05 also will allow me to expand my knowledge of worksite organizational practices, policies influencing worksite health, and the organization of worksite health promotion and health protection in the marketplace; provide protected time for synthesis and writing about cross-cutting themes and implications for practice; and expand my skills for my research in India. I am eager to expand the mentoring made possible through this award. I will commit 25% of my total effort to provide mentoring for junior faculty, post-doctoral fellows, and doctoral students, with the aim that they will make significant and meaningful contributions to research aimed at reducing disparities in cancer risk, and increasingly, with a focus on worksite cancer prevention research. I will also expand my leadership around excellence in mentoring, in order to increase the salience placed on mentoring by other senior investigators. In addition, I expect to mentor and build capacity for research among cancer prevention investigators in India and other developing countries. My institutional homes at the Dana-Farber Cancer Institute and Harvard School of Public Health have demonstrated outstanding commitment to the work included in this K05. Each of these institutions provides numerous resources and opportunities for both my research and mentoring activities.