Estrogen metabolite profiling of thin tissue sections

薄组织切片的雌激素代谢谱分析

• 批准号: 8554721
• 负责人: Donald Johann
• 金额: $ 3.43万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8554721
• 关键词: Area; Aromatase; Biological Assay; Biological Markers; Clinical; Endocrinology; Estrogen Receptor Status; Estrogens; Freezing; Genomics; Hormones; Human Genome; Ligands; Malignant Neoplasms; Malignant neoplasm of lung; Methods; Pathway interactions; Proteomics; Research; Signal Transduction; Solid Neoplasm; Tissues; Tumor Tissue; cancer site; insight; malignant breast neoplasm; receptor; steroid hormone; translational study; tumor

Many cancers are hormonally driven. Ultimately, a predictive assay combining information from tumor estrogen receptor status, mutational analysis, aromatase levels and estrogen metabolite analysis may prove to have clinical benefit. Estrogen metabolites profiled from tumor tissue may aid in evolving a strategy that targets cancer pathways in solid tumors by enhancing our understanding of estrogens produced locally via aromatase or via ligand dependent signaling. Ultimately, a rational co-inhibition of ER and related receptors may result in greater anti-tumor activity.

许多癌症都是由神经驱动的。最终，结合肿瘤雌激素受体状态、突变分析、芳香化酶水平和雌激素代谢物分析的信息的预测性测定可能被证明具有临床益处。从肿瘤组织中分析的雌激素代谢物可能有助于发展一种策略，该策略通过增强我们对经由芳香酶或经由配体依赖性信号传导局部产生的雌激素的理解来靶向实体瘤中的癌症途径。最终，ER和相关受体的合理共抑制可能导致更大的抗肿瘤活性。