Estrogen metabolite profiling of thin tissue sections

许多癌症是由激素驱动的。最终，结合肿瘤雌激素受体状态、突变分析、芳香化酶水平和雌激素代谢物分析等信息的预测分析可能会证明具有临床益处。来自肿瘤组织的雌激素代谢物可能有助于通过增强我们对通过芳香化酶或配体依赖信号在局部产生的雌激素的理解，来发展一种针对实体肿瘤中癌症途径的策略。最终，合理的共抑制内质网和相关受体可能导致更大的抗肿瘤活性。

Many cancers are hormonally driven. Ultimately, a predictive assay combining information from tumor estrogen receptor status, mutational analysis, aromatase levels and estrogen metabolite analysis may prove to have clinical benefit. Estrogen metabolites profiled from tumor tissue may aid in evolving a strategy that targets cancer pathways in solid tumors by enhancing our understanding of estrogens produced locally via aromatase or via ligand dependent signaling. Ultimately, a rational co-inhibition of ER and related receptors may result in greater anti-tumor activity.