Estrogen metabolite profiling of thin tissue sections

薄组织切片的雌激素代谢谱分析

• 批准号: 8157717
• 负责人: Donald Johann
• 金额: $ 6.3万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157717
• 关键词: Estrogens; Tissues

Many cancers are hormonally driven. Ultimately, a predictive assay combining information from tumor estrogen receptor status, mutational analysis, aromatase levels and estrogen metabolite analysis may prove to have clinical benefit. Estrogen metabolites profiled from tumor tissue may aid in evolving a strategy that targets cancer pathways in solid tumors by enhancing our understanding of estrogens produced locally via aromatase or via ligand dependent signaling. Ultimately, a rational co-inhibition of ER and related receptors may result in greater anti-tumor activity.

许多癌症是由激素驱动的。最终，结合肿瘤雌激素受体状态、突变分析、芳香化酶水平和雌激素代谢物分析等信息的预测分析可能会证明具有临床益处。来自肿瘤组织的雌激素代谢物可能有助于通过增强我们对通过芳香化酶或配体依赖信号在局部产生的雌激素的理解，来发展一种针对实体肿瘤中癌症途径的策略。最终，合理的共抑制内质网和相关受体可能导致更大的抗肿瘤活性。