Molecular profiling of tumor tissue using targeted clinical proteomics

使用靶向临床蛋白质组学对肿瘤组织进行分子分析

• 批准号: 8157766
• 负责人: Donald Johann
• 金额: $ 12.61万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157766
• 关键词: Clinical; Diagnosis; Economic Burden; Medical Economics; Molecular Profiling; Proteomics; Tumor Tissue

Our results have shown the ability to detect tumor residing proteins in the blood of a patient with a newly diagnosed non-metastatic cancer. In depth proteomic profiling of an individual patient's tumor for further elucidation of the particular molecular phenotype. A panel of putative markers are under investigation with high throughput techniques employing suitable immunoassays to test for general applicability to a much larger patient cohorts with this particular solid organ tumor. Such an approach facilitates maximization of therapeutic efficacy, minization of toxicities, and an attempt to reduce medical economic burdens.

我们的结果表明，我们能够检测到新诊断的非转移性癌症患者血液中的肿瘤残留蛋白。对单个患者的肿瘤进行深入的蛋白质组学分析，以进一步阐明特定的分子表型。一组可能的标记物正在用高通量技术进行研究，使用合适的免疫分析方法来测试其对患有这种特殊实体器官肿瘤的更大规模的患者队列的普遍适用性。这种方法有助于最大限度地提高治疗效果，减少毒性，并试图减少医疗经济负担。