Life-span Evolution of the Capabilities of Rhesus Monkeys

人们对理解早期生命状况和随后的生命所起的作用非常感兴趣 环境在决定因素中发挥作用：成年人的年龄、健康、社会经济结果、个性和认知。 同样有趣的是了解个性和认知对健康、衰老和 社会经济结果。人们对了解可能的补偿途径也很感兴趣， 这些领域的补救和复原力。人类发展的机制植根于生物学、心理学 和环境对于设计促进健康、减少不平等和发展的政策是必不可少的 人类的潜力。对这些机制的适当研究需要关于基因的详细的生命周期信息， 环境和生物学。当研究几代人的时候，人们可以更好地研究家庭的影响 影响，以及环境在改善或加剧初始天赋方面的作用。即使对一项关于 人类在一代人之内，必要的数据是稀缺的；代际数据更是支离破碎。 对人类的实验证据也是有限的。恒河猴在基因和社会上都与 人类。已经收集了关于恒河猴及其环境的丰富数据，包括 世代，这将用于这个项目。此外，该项目将从各种不同的数据中生成新数据 干预的结果。有了这些数据，就有可能研究恒河猴能力的演变，并研究 剥夺和补救在生命周期发育中的作用。在动物权利协议规定的范围内， 该项目将设计不利的早期和青春期环境。该项目将利用许多 在恒河猴的五个区间内采样的猴子的生物学(健康)、认知和个性的测量 生命周期和执行各种环境干预措施对这些数据的分析将揭示新的 经验关系和对生物起源和发展的更深层次的理解 在接近人类的动物物种中的能力。将使用尖端方法处理这些数据 对这些猕猴种群进行针对人类种群开发的基因分析。该项目将 分析社会因素如何在动态环境中调节基因表达，特别是哪些基因集 对社会影响很敏感，这些影响是如何转化到 以及固有的遗传特征可能如何调节社会环境的影响。这些数据将 使用生命周期技能形成的动态计量模型进行分析，该模型将指导制定 针对人类的政策分析。对恒河猴的分析将作为一个原型，说明在 研究人的发展。

There is substantial interest in understanding the role that early life conditions and subsequent life environments play in determining: adult aging, health, socioeconomic outcomes, personality and cognition. Also of interest is understanding the effects that personality and cognition have on health, aging and socioeconomic outcomes. There is also great interest in understanding possible avenues of compensation, remediation and resilience in these areas. Mechanisms of human development rooted in biology, psychology and the environment are essential to designing policies that promote health, reduce inequality, and develop human potential. A proper study of these mechanisms requires detailed life cycle information on genes, environments and biology. When examined across generations, one can better examine the effects of family influence, and the role of environments in ameliorating or exacerbating initial endowments. Even for a study of humans within a generation, the requisite data are scarce; intergenerational data are even more fragmentary. Experimental evidence for humans is also limited. Rhesus monkeys are genetically and socially similar to humans. Rich data has been collected on rhesus monkeys and their environments, between and across generations, which will be used for this project. Furthermore, this project will generate new data from a variety of interventions. With these data, it is possible to study the evolution of rhesus capabilities and to examine the role of deprivation and remediation in life cycle development. Within limits dictated by animal rights protocols, this project will engineer adverse early and adolescent environments. The project will utilize numerous measures of biology (health), cognition and personality for monkeys sampled over five intervals of the rhesus life cycles and performs a variety of environmental interventions Analyses of these data will reveal new empirical relationships and a deeper, biologically-based understanding of the origins and development of capabilities in an animal species close to humans. Cutting-edge methodology will be used with this data to conduct gene analysis developed for human populations on these rhesus monkey populations. The project will analyze how social factors regulate gene expression in a dynamic setting and in particular which sets of genes are sensitive to social influences, how these influences are transduced into the molecular environment of the cell, and how inherent genetic characteristics might modulate socio-environmental influences. These data will be analyzed using a dynamic econometric model of life cycle skill formation that will guide the formulation of policy analysis for humans. An analysis of rhesus monkeys will serve as a prototype for what is possible in the study of human development.