Medical Genetics Training Program

描述(申请人提供)：在过去的几十年里，人类遗传学已经成为基础和生物医学研究的中心焦点，并且是一个真正的综合领域。对人类疾病分子基础的研究有望为我们对疾病发病机制的基本理解提供重要的见解，并在治疗和临床应用方面具有巨大的前景。本申请申请资金用于在哥伦比亚大学医学中心建立医学遗传学培训计划，以支持大学范围内关于人类遗传学主题的培训计划，每年支持三名博士后实习生。培训的重点是儿童和成人孟德尔病和复杂疾病的临床、分子和遗传方面。医学遗传学培训计划的主要优势是培训教师的卓越质量和多样性，为学员提供在国际公认的实验室和临床环境中进行博士后研究的机会。代表许多不同部门的23名教职员工参加了这项培训计划，他们拥有丰富的培训经验和出色的培训师和导师记录。我们的使命是推动人类遗传学基础科学的发展，并通过转译研究将这些进展纳入临床实践。该培训基金的目标直接与NIGMS支持的医学遗传学博士后培训计划保持一致，该计划旨在促进人类遗传学基础和临床方面的研究事业。我们培训计划的临床、教学和研究部分旨在为从事学术医学事业的内科科学家做准备。医学遗传学培训计划将为博士后实习生提供出色的全面培训经验，使他们能够追求未来的学术生涯，并从CUMC的许多不同项目创建一个促进人类遗传学进步的论坛。

DESCRIPTION (provided by applicant): Human Genetics has become a central focus of basic and biomedical research over the past decades, and is truly an integrative field. The study of the molecular basis of human disease promises to yield significant insights into our basic understanding of disease pathogenesis, and holds enormous promise in terms of therapeutic and clinical applications. This application requests funds to establish a Medical Genetics Training Program at Columbia University Medical Center to support three postdoctoral trainees per year, in a University-wide training program on the topic of Human Genetics. Training focuses on the clinical, molecular and genetic aspects of both Mendelian and complex diseases in children and adults. The major strength of the Medical Genetics Training Program is the outstanding quality and diversity of the training faculty, which provides trainees with the opportunity to perform postdoctoral research in laboratories and clinical settings that are internationally recognized. Twenty three faculty members representing many different Departments are included in this training program and have extensive experience and outstanding track records as trainers and mentors. Our mission is to advance the science underlying human genetics, and incorporate these advances into clinical practice through translational research. The goals of this Training Grant are directly aligned with NIGMS-supported postdoctoral training programs in medical genetics, which are designed to foster research careers in both basic and clinical aspects of human genetics. The clinical, didactic and research components of our Training Program are intended to prepare physician- scientists for a career in academic medicine. The Medical Genetics Training Program will provide an outstanding well-rounded training experience for postdoctoral trainees that will allow them to pursue a future academic career, and create a forum for the advancement of human genetics from many different programs at CUMC.