Multimode laser optoacoustic tomography system for breast cancer care

用于乳腺癌护理的多模激光光声断层扫描系统

基本信息

  • 批准号:
    8274917
  • 负责人:
  • 金额:
    $ 53万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-05-01 至 2017-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): "Multimode Laser Optoacoustic Tomography System for Breast Cancer Care" The broad objective of the proposed project is to overcome the limitations of current breast imaging methods by developing a novel multimode three-dimensional (3D) breast imager that generates 5 different images based on optoacoustic tomography (OAT) and laser ultrasound tomography (UST). The rationale for combining OAT and laser UST into a multimode breast imaging method is clear and compelling, since both, OAT and UST are individually receiving significant attention as promising breast cancer imaging methods. OAT can provide two types of images: (1) image of the total hemoglobin associated with density of tumor angiogenesis and (2) image of blood oxygen saturation. This functional (molecular) information related to breast tissue blood content can help to detect early but aggressively growing breast tumors that are hard to detect with (x-ray) mammography, especially in radiologically dense breasts of younger women. On the other hand, UST can provide high-resolution anatomical images of breast lesions based on three complementary acoustic properties (1) speed-of-sound (SOS), (2) acoustic attenuation, and (3) ultrasound reflectivity. By combining OAT and laser UST we will establish an imaging system that can provide comprehensive co- registered functional and anatomical information without the need for breast compression, ionizing radiation, or contrast agents. Furthermore, using laser generation of ultrasound we will significantly improve performance (sensitivity and resolution) of the ultrasound tomography. Our hypothesis is that coregistration and correlation of 5 different images, the proposed imaging technology will provide ultimate sensitivity and specificity. When clinically validated, the new multimode 3D imaging technology will transform breast cancer care by providing not only a better screening (detection) method, but also will serve as a highly effective tool for differentiation and characterization of breast tumors, a feature critical for diagnostics and monitoring the immediate effects of various anticancer therapies. In this project, we will develop technology (system hardware and software algorithms) and test this multi-modality imager in clinical studies on patients present with small size non- palpable breast tumors suspicious for malignancy. The Specific Aims of the project are: (1) Develop, fabricate and implement an optoacoustic plus laser ultrasonic 3D tomography imager based on rotating arc-shaped array of ultrawide-band ultrasonic transducers, (2) Develop and evaluate robust OAT image reconstruction methods for use with the developed imager, (3) Develop 3D ultrasound and multimode (OAT+UST) image reconstruction methods for use with the developed imager, and (4) experimentally validate the imaging system using breast mimicking phantoms and 96 human subjects. The successful completion of the project will produce conclusive data to motivate a systematic multicenter appropriately statistically powered FDA-guided study to evaluate the effectiveness of the developed system and determine the full range of clinical indications. PUBLIC HEALTH RELEVANCE: "Multimode Laser Optoacoustic Tomography System for Breast Cancer Care" Detection and treatment of the early stages of breast cancer is essential to the reduction to cancer mortality. The proposed imaging technology will provide significantly improved contrast and resolution for unambiguous detection and diagnostic differentiation of early aggressively growing malignant from benign tumors. The combined dual modality (optoacoustic plus laser ultrasonic) system will possess the ability to detect early breast tumors with excellent sensitivity and noninvasively characterize and stage breast tumors with ultimate specificity. The proposed system will be applicable to women of all ages independently on radiological density of their breasts.
描述(申请人提供):“用于乳腺癌护理的多模激光光声断层成像系统”该项目的主要目标是通过开发一种基于光声断层扫描(OAT)和激光超声断层扫描(UST)生成5种不同图像的新型多模三维(3D)乳房成像仪来克服当前乳房成像方法的局限性。将OAT和激光UST结合到多模乳房成像方法中的原理是明确和令人信服的,因为OAT和UST分别作为有前景的乳腺癌成像方法受到了极大的关注。OAT可提供两种类型的图像:(1)与肿瘤血管生成密度相关的总血红蛋白图像和(2)血氧饱和度图像。这种与乳腺组织血液含量相关的功能(分子)信息可以帮助发现早期但侵袭性生长的乳腺肿瘤,这些肿瘤很难通过(X-射线)乳房X光检查发现,特别是在年轻女性放射致密的乳房。另一方面,UST可以基于三个互补的声学特性(1)声速(SOS)、(2)声衰减和(3)超声反射率提供高分辨率的乳腺病变解剖图像。通过将OAT和激光UST相结合,我们将建立一个成像系统,该系统可以提供全面的联合注册功能和解剖信息,而不需要乳房按压、电离辐射或造影剂。此外,使用激光产生超声波,我们将显著提高超声断层扫描的性能(灵敏度和分辨率)。我们的假设是,5个不同图像的共同配准和相关性,所提出的成像技术将提供最终的敏感性和特异性。在临床验证后,新的多模式3D成像技术将改变乳腺癌的治疗,不仅提供更好的筛查(检测)方法,而且将成为区分和表征乳腺肿瘤的高效工具,这一功能对于诊断和监测各种抗癌治疗的即时效果至关重要。在这个项目中,我们将开发技术(系统硬件和软件算法),并在临床研究中测试这种多模式成像仪,这些患者患有疑似恶性肿瘤的小体积不可触及的乳腺肿瘤。该项目的具体目标是:(1)开发、制造和实施基于超宽带超声换能器旋转弧形阵列的光声加激光三维超声层析成像仪;(2)开发和评估用于所开发成像仪的稳健OAT图像重建方法;(3)开发用于所开发成像仪的三维超声和多模(OAT+UST)图像重建方法;以及(4)使用模仿乳房的体模和96名人类受试者对成像系统进行实验验证。该项目的成功完成将产生决定性的数据,以激励一项由FDA提供适当统计数据的系统性多中心研究,以评估所开发系统的有效性并确定全部临床适应症。 公共卫生意义:“用于乳腺癌护理的多模激光光声断层扫描系统”乳腺癌早期阶段的检测和治疗对于降低癌症死亡率至关重要。所提出的成像技术将为早期侵袭性生长的恶性肿瘤和良性肿瘤的明确检测和诊断鉴别提供显著提高的对比度和分辨率。结合双模式(光声+激光超声)的系统将具有良好的敏感性和非侵袭性的乳腺肿瘤的早期诊断能力,并以最终的特异性对乳腺肿瘤进行定性和分期。拟议的系统将适用于所有年龄的妇女,独立于她们乳房的放射密度。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ALEXANDER A ORAEVSKY其他文献

ALEXANDER A ORAEVSKY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ALEXANDER A ORAEVSKY', 18)}}的其他基金

Multimode laser optoacoustic tomography system for breast cancer care
用于乳腺癌护理的多模激光光声断层扫描系统
  • 批准号:
    8637017
  • 财政年份:
    2012
  • 资助金额:
    $ 53万
  • 项目类别:
Multimode laser optoacoustic tomography system for breast cancer care
用于乳腺癌护理的多模激光光声断层扫描系统
  • 批准号:
    8464035
  • 财政年份:
    2012
  • 资助金额:
    $ 53万
  • 项目类别:
Laser Ultrasound and Optoacoustic Endoscopy of Esophagus
食管激光超声和光声内窥镜检查
  • 批准号:
    8315046
  • 财政年份:
    2012
  • 资助金额:
    $ 53万
  • 项目类别:
Optoacoustic system for monitoring biodistribution of nanoparticles in vivo.
用于监测体内纳米颗粒生物分布的光声系统。
  • 批准号:
    8203540
  • 财政年份:
    2011
  • 资助金额:
    $ 53万
  • 项目类别:
Optoacoustic imaging enhanced by gold nanorods
金纳米棒增强光声成像
  • 批准号:
    7940027
  • 财政年份:
    2009
  • 资助金额:
    $ 53万
  • 项目类别:
Optoacoustic imaging enhanced by gold nanorods
金纳米棒增强光声成像
  • 批准号:
    8487856
  • 财政年份:
    2009
  • 资助金额:
    $ 53万
  • 项目类别:
3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer
用于乳腺癌诊断成像的 3D 混合光声超声系统
  • 批准号:
    8495494
  • 财政年份:
    2007
  • 资助金额:
    $ 53万
  • 项目类别:
3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer
用于乳腺癌诊断成像的 3D 混合光声超声系统
  • 批准号:
    7688775
  • 财政年份:
    2007
  • 资助金额:
    $ 53万
  • 项目类别:
3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer
用于乳腺癌诊断成像的 3D 混合光声超声系统
  • 批准号:
    7695560
  • 财政年份:
    2007
  • 资助金额:
    $ 53万
  • 项目类别:
3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer
用于乳腺癌诊断成像的 3D 混合光声超声系统
  • 批准号:
    7272931
  • 财政年份:
    2007
  • 资助金额:
    $ 53万
  • 项目类别:

相似国自然基金

靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    0 万元
  • 项目类别:
    面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
  • 批准号:
    2023JJ50274
  • 批准年份:
    2023
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    33 万元
  • 项目类别:
    地区科学基金项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
  • 批准号:
    n/a
  • 批准年份:
    2022
  • 资助金额:
    10.0 万元
  • 项目类别:
    省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
  • 批准号:
    81973577
  • 批准年份:
    2019
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
  • 批准号:
    81602908
  • 批准年份:
    2016
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
  • 批准号:
    81501928
  • 批准年份:
    2015
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
  • 批准号:
    2341426
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
  • 批准号:
    2341424
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政​​策的情绪动态
  • 批准号:
    10108433
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
  • 批准号:
    MR/X032809/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
  • 批准号:
    MR/X034690/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
  • 批准号:
    24K13490
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
  • 批准号:
    EP/Z00022X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
  • 批准号:
    MR/Y003365/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
  • 批准号:
    2335955
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
  • 批准号:
    AH/Y007549/1
  • 财政年份:
    2024
  • 资助金额:
    $ 53万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了