Laser Ultrasound and Optoacoustic Endoscopy of Esophagus

食管激光超声和光声内窥镜检查

• 批准号: 8315046
• 负责人: ALEXANDER A ORAEVSKY
• 金额: $ 13.17万
• 依托单位: TOMOWAVE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-08 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8315046
• 关键词: Acoustics; Blood Vessels; Breast; Caliber; Cancerous; Chickens; Clinic; Collaborations; Complex; Custom; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Diagnostic Procedure; Dimensions; Electronics; Elements; Endoscopes; Endoscopy; Esophageal; Esophagus; Focused Ultrasound Therapy; Foundations; Frequencies; Future; Grant; Head and neck structure; Hospitals; Image; Imagery; Imaging technology; Lasers; Lateral; Length; Malignant Neoplasms; Malignant neoplasm of esophagus; Methodist Church; Modality; Normal tissue morphology; Optics; Performance; Phase; Physiologic pulse; Polymers; Property; Pulse Pressure; Qualifying; Relative (related person); Research; Resolution; Sampling; Scanning; Screening procedure; Sensitivity and Specificity; Shapes; Signal Transduction; Small Business Innovation Research Grant; Source; Speed; Staging; Structure; System; Technology; Testing; Tissues; Transducers; Tumor stage; Ultrasonography; absorption; angiogenesis; base; beef; clinical practice; commercialization; data acquisition; density; design; electric impedance; imaging modality; improved; innovation; instrument; instrumentation; malignant breast neoplasm; miniaturize; notch protein; novel; novel diagnostics; operation; polyvinylidene fluoride; preclinical evaluation; professor; prototype; research clinical testing; sound; tomography; tool; tumor

DESCRIPTION (provided by applicant): "Laser Ultrasound and Optoacoustic Endoscopy of Esophagus" We propose development of a novel commercial dual-modality imaging system which will integrate laser ultrasound and optoacoustic imaging capabilities in a compact package suitable for endoscopy of esophagus. There is a pressing need for versatile and effective instrumentation capable of detecting deadly esophageal cancer in its early stages. Ultrasound imaging has been proven effective in identifying and staging of relatively advanced tumors in esophageal wall lining based on differences in their density and speed of sound (acoustic impedance) relative to normal tissues. Optoacoustic imaging is a novel complementary imaging modality which combines optics and high-resolution of ultrasound to generate images based on optical properties of tissues. Enhanced performance of the dual-mode optoacoustic-ultrasound imaging as compared to conventional ultrasound was clinically demonstrated in detection and staging of breast cancers, and the optoacoustic imaging technology have been commercialized. We reasonably expect that the proposed device will significantly improve diagnostic capability of ultrasound endoscopy and therefore be highly desired in clinical practice. The proposed optoacoustic/ultrasound imaging system will utilize a number of innovations which will allow us to achieve top-notch performance and versatility. Our first key innovation involves the use an off-axis parabolic reflector in conjunction with a flat transducer array for optoacoustic endoscopy. The reflector, as we demonstrated, provides and ideal conversion of a spherical wavefront into a plane wave without losses or distortions. The use of a transducer array will allow us to expand limited depth of view of the focused system using dynamic ultrasound focusing and wavefront corrections. With an array, approximately 10-fold larger volume can be imaged in a single step as compared to diffraction-limited volume of a focused system. Finally, we propose to add ultrasound imaging capability to the optoacoustic endoscope using laser-generated ultrasound. A removable absorbing and acoustically transparent layer placed in the path of laser beam will generate strong and broadband pressure pulses propagating towards a sample and the reflected signals will be used to recreate an ultrasound image. This innovation will eliminate the need for pulse-receive switches known to generate electronic interference and will allow optimization of the transducer design for detection mode only, thereby simplifying and enhancing sensitivity of an imaging system. The PI is an internationally recognized leader in optoacoustic imaging technology and its commercialization and will guide the team of highly qualified experts in ultrasound imaging and optoacoustic tomography towards successful completion of a project. At present, no compact dual-mode optoacoustic-ultrasound imaging systems suitable for endoscopy applications have been either developed or commercialized. The proposed research will create a foundation towards development and future commercialization of a novel instrument. Our dual-modality optoacoustic-ultrasound imaging system is expected to have a high demand in clinic for functional endoscopy of esophagus. PUBLIC HEALTH RELEVANCE: "Laser Ultrasound and Optoacoustic Endoscopy of Esophagus" Efficient imaging technologies capable of early stage detection of deadly esophageal cancers are need in clinical practice. Here we proposed to enhance conventional ultrasound imaging used for detection and staging of tumors in esophageal lining by introducing a novel dual-mode optoacoustic-ultrasound imaging endoscopy system. The proposed design based on an off-axis parabolic reflector in conjunction with a transducer array will provide a significantly improved resolution, depth of focus, and the rate of data acquisition as compared to prior optoacoustic endoscopy designs. The use of laser-ultrasound to perform conventional ultrasound imaging will not complicate the probe design and will significantly expand its utility fr detecting and staging of esophageal cancers. The proposed dual-modality optoacoustic-ultrasound imaging system is expected to have a high demand in clinic for functional endoscopy of esophagus.

描述(申请人提供)：“激光超声和光声食道内窥镜”我们建议开发一种新型的商用双模式成像系统，该系统将激光超声和光声成像功能集成在一个紧凑的封装中，适用于食道内窥镜检查。迫切需要一种通用和有效的仪器，能够在食道癌的早期阶段检测出致命的食道癌。超声成像已被证明是有效的识别和分期相对进展期的食管壁衬里肿瘤基于其密度和声速(声阻抗)相对于正常组织的差异。光声成像是一种新型的互补成像方式，它结合了光学和超声的高分辨率，根据组织的光学特性生成图像。双模光声-超声成像在乳腺癌的检测和分期中的性能优于传统超声，并且光声成像技术已经商业化。我们有理由预计，所提出的设备将显着提高超声内窥镜的诊断能力，因此在临床实践中有很高的期望。建议的光声/超声成像系统将利用许多创新，使我们能够实现一流的性能和多功能性。我们的第一个关键创新是使用离轴抛物面反射器和平面换能器阵列进行光声内窥镜检查。正如我们所展示的，该反射器提供了理想的球面波前到平面波的转换，而没有损耗或失真。换能器阵列的使用将允许我们使用动态超声聚焦和波前校正来扩展聚焦系统的有限深度。与聚焦系统的衍射限制体积相比，使用阵列可以在一次步骤中成像大约10倍大的体积。最后，我们建议使用激光产生的超声为光声内窥镜增加超声成像能力。放置在激光束路径上的可移除的吸收和声学透明层将产生向样品传播的强而宽带的压力脉冲，并且反射信号将被用于重建超声图像。这一创新将消除对已知产生电子干扰的脉冲接收开关的需要，并将允许仅针对检测模式优化换能器设计，从而简化和提高成像系统的灵敏度。PI在光声成像技术及其商业化方面是国际公认的领导者，并将指导超声成像和光声断层扫描领域的高素质专家团队成功完成一个项目。目前，还没有适合内窥镜应用的紧凑型双模光声-超声成像系统被开发或商业化。拟议的研究将为一种新型仪器的开发和未来的商业化奠定基础。我们的双模式光声-超声成像系统有望在临床上对食道功能内窥镜有很高的需求。 公共卫生相关性：食道激光超声和光声内窥镜在临床实践中需要能够早期发现致命食道癌的高效成像技术。在这里，我们建议通过引入一种新型的双模光声-超声成像内窥镜系统来增强用于检测和分期食道衬里肿瘤的常规超声成像。与以前的光声内窥镜设计相比，基于离轴抛物面反射器和换能器阵列的拟议设计将提供显著提高的分辨率、焦深和数据采集速率。使用激光超声进行常规超声成像不会使探头设计复杂化，并将显著扩大其在食道癌检测和分期中的应用。所提出的光声-超声双模式成像系统有望在临床上对食道功能性内窥镜检查有很高的需求。

项目成果

All-optical optoacoustic microscopy based on probe beam deflection technique.

• DOI: 10.1016/j.pacs.2016.02.001
• 发表时间: 2016-09
• 期刊: PHOTOACOUSTICS
• 影响因子: 7.9
• 作者: Maswadi, Saher M.;Ibey, Bennett L.;Roth, Caleb C.;Tsyboulski, Dmitri A.;Beier, Hope T.;Glickman, Randolph D.;Oraevsky, Alexander A.
• 通讯作者: Oraevsky, Alexander A.