Laser Ultrasound and Optoacoustic Endoscopy of Esophagus

食管激光超声和光声内窥镜检查

• 批准号: 8315046
• 负责人: ALEXANDER A ORAEVSKY
• 金额: $ 13.17万
• 依托单位: TOMOWAVE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-08 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8315046
• 关键词: Acoustics; Blood Vessels; Breast; Caliber; Cancerous; Chickens; Clinic; Collaborations; Complex; Custom; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Diagnostic Procedure; Dimensions; Electronics; Elements; Endoscopes; Endoscopy; Esophageal; Esophagus; Focused Ultrasound Therapy; Foundations; Frequencies; Future; Grant; Head and neck structure; Hospitals; Image; Imagery; Imaging technology; Lasers; Lateral; Length; Malignant Neoplasms; Malignant neoplasm of esophagus; Methodist Church; Modality; Normal tissue morphology; Optics; Performance; Phase; Physiologic pulse; Polymers; Property; Pulse Pressure; Qualifying; Relative (related person); Research; Resolution; Sampling; Scanning; Screening procedure; Sensitivity and Specificity; Shapes; Signal Transduction; Small Business Innovation Research Grant; Source; Speed; Staging; Structure; System; Technology; Testing; Tissues; Transducers; Tumor stage; Ultrasonography; absorption; angiogenesis; base; beef; clinical practice; commercialization; data acquisition; density; design; electric impedance; imaging modality; improved; innovation; instrument; instrumentation; malignant breast neoplasm; miniaturize; notch protein; novel; novel diagnostics; operation; polyvinylidene fluoride; preclinical evaluation; professor; prototype; research clinical testing; sound; tomography; tool; tumor

DESCRIPTION (provided by applicant): "Laser Ultrasound and Optoacoustic Endoscopy of Esophagus" We propose development of a novel commercial dual-modality imaging system which will integrate laser ultrasound and optoacoustic imaging capabilities in a compact package suitable for endoscopy of esophagus. There is a pressing need for versatile and effective instrumentation capable of detecting deadly esophageal cancer in its early stages. Ultrasound imaging has been proven effective in identifying and staging of relatively advanced tumors in esophageal wall lining based on differences in their density and speed of sound (acoustic impedance) relative to normal tissues. Optoacoustic imaging is a novel complementary imaging modality which combines optics and high-resolution of ultrasound to generate images based on optical properties of tissues. Enhanced performance of the dual-mode optoacoustic-ultrasound imaging as compared to conventional ultrasound was clinically demonstrated in detection and staging of breast cancers, and the optoacoustic imaging technology have been commercialized. We reasonably expect that the proposed device will significantly improve diagnostic capability of ultrasound endoscopy and therefore be highly desired in clinical practice. The proposed optoacoustic/ultrasound imaging system will utilize a number of innovations which will allow us to achieve top-notch performance and versatility. Our first key innovation involves the use an off-axis parabolic reflector in conjunction with a flat transducer array for optoacoustic endoscopy. The reflector, as we demonstrated, provides and ideal conversion of a spherical wavefront into a plane wave without losses or distortions. The use of a transducer array will allow us to expand limited depth of view of the focused system using dynamic ultrasound focusing and wavefront corrections. With an array, approximately 10-fold larger volume can be imaged in a single step as compared to diffraction-limited volume of a focused system. Finally, we propose to add ultrasound imaging capability to the optoacoustic endoscope using laser-generated ultrasound. A removable absorbing and acoustically transparent layer placed in the path of laser beam will generate strong and broadband pressure pulses propagating towards a sample and the reflected signals will be used to recreate an ultrasound image. This innovation will eliminate the need for pulse-receive switches known to generate electronic interference and will allow optimization of the transducer design for detection mode only, thereby simplifying and enhancing sensitivity of an imaging system. The PI is an internationally recognized leader in optoacoustic imaging technology and its commercialization and will guide the team of highly qualified experts in ultrasound imaging and optoacoustic tomography towards successful completion of a project. At present, no compact dual-mode optoacoustic-ultrasound imaging systems suitable for endoscopy applications have been either developed or commercialized. The proposed research will create a foundation towards development and future commercialization of a novel instrument. Our dual-modality optoacoustic-ultrasound imaging system is expected to have a high demand in clinic for functional endoscopy of esophagus. PUBLIC HEALTH RELEVANCE: "Laser Ultrasound and Optoacoustic Endoscopy of Esophagus" Efficient imaging technologies capable of early stage detection of deadly esophageal cancers are need in clinical practice. Here we proposed to enhance conventional ultrasound imaging used for detection and staging of tumors in esophageal lining by introducing a novel dual-mode optoacoustic-ultrasound imaging endoscopy system. The proposed design based on an off-axis parabolic reflector in conjunction with a transducer array will provide a significantly improved resolution, depth of focus, and the rate of data acquisition as compared to prior optoacoustic endoscopy designs. The use of laser-ultrasound to perform conventional ultrasound imaging will not complicate the probe design and will significantly expand its utility fr detecting and staging of esophageal cancers. The proposed dual-modality optoacoustic-ultrasound imaging system is expected to have a high demand in clinic for functional endoscopy of esophagus.

描述（由申请人提供）：“食管的激光超声和光声内窥镜检查”我们提出开发一种新型的商业双模态成像系统，该系统将激光超声和光声成像能力集成在适合于食管内窥镜检查的紧凑包装中。迫切需要能够在早期阶段检测致命食管癌的多功能和有效的仪器。超声成像已被证明有效地识别和分期相对先进的肿瘤在食管壁衬里的基础上的差异，其密度和声速（声阻抗）相对于正常组织。光声成像是一种新型的互补成像方式，它结合了光学和高分辨率的超声，以产生基于组织的光学特性的图像。与传统超声相比，双模式光声超声成像的增强性能在乳腺癌的检测和分期中得到了临床证明，并且光声成像技术已经商业化。我们合理地预期，所提出的设备将显着提高超声内窥镜的诊断能力，因此在临床实践中非常需要。拟议的光声/超声成像系统将利用一些创新，这将使我们能够实现一流的性能和多功能性。我们的第一个关键创新涉及使用离轴抛物面反射器结合平面换能器阵列的光声内窥镜。正如我们所证明的，反射器提供了球面波阵面到平面波的理想转换，而没有损失或失真。换能器阵列的使用将允许我们使用动态超声聚焦和波前校正来扩展聚焦系统的有限景深。使用阵列，与聚焦系统的衍射限制体积相比，可以在单个步骤中成像大约10倍大的体积。最后，我们建议增加超声成像能力的光声内窥镜使用激光产生的超声。放置在激光束路径中的可移除吸收和透声层将产生朝向样品传播的强宽带压力脉冲，并且反射的信号将用于重建超声图像。这种创新将消除对已知会产生电子干扰的脉冲接收开关的需要，并且将允许仅针对检测模式优化换能器设计，从而简化和增强成像系统的灵敏度。PI是国际公认的光声成像技术及其商业化的领导者，将指导超声成像和光声断层扫描领域的高素质专家团队成功完成项目。目前，还没有适合于内窥镜应用的紧凑型双模光声超声成像系统被开发或商业化。拟议的研究将为新型仪器的开发和未来商业化奠定基础。我们的双模态光声-超声成像系统有望在临床食管功能性内窥镜检查中有很高的需求。 公共卫生关系：“食道激光超声和光声内窥镜检查”临床实践中需要能够早期检测致命食道癌的高效成像技术。在这里，我们建议通过引入一种新型的双模光声超声成像内窥镜系统来增强用于食管衬里肿瘤检测和分期的传统超声成像。与现有的光声内窥镜设计相比，基于离轴抛物面反射器结合换能器阵列的所提出的设计将提供显著改善的分辨率、焦深和数据采集速率。使用激光超声进行常规超声成像不会使探头设计复杂化，并且将显著扩展其用于食管癌的检测和分期的实用性。本研究所提出之双模态光声-超音波影像系统，可望在临床上应用于功能性食道内视镜检查有较高的需求。

项目成果

All-optical optoacoustic microscopy based on probe beam deflection technique.

• DOI: 10.1016/j.pacs.2016.02.001
• 发表时间: 2016-09
• 期刊: PHOTOACOUSTICS
• 影响因子: 7.9
• 作者: Maswadi, Saher M.;Ibey, Bennett L.;Roth, Caleb C.;Tsyboulski, Dmitri A.;Beier, Hope T.;Glickman, Randolph D.;Oraevsky, Alexander A.
• 通讯作者: Oraevsky, Alexander A.