Multimode laser optoacoustic tomography system for breast cancer care

用于乳腺癌护理的多模激光光声断层扫描系统

• 批准号: 8464035
• 负责人: ALEXANDER A ORAEVSKY
• 金额: $ 50.22万
• 依托单位: TOMOWAVE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464035
• 关键词: Acoustics; Age; Algorithms; Attention; Benign; Biochemical; Biopsy; Blood; Breast; Breast Cancer Detection; Cancer Center; Cancerous; Clinical; Clinical Research; Clinical Trials; Color; Computer software; Contrast Media; Custom; Data; Detection; Diagnostic; Diagnostic Specificity; Dyes; Early treatment; Effectiveness; Electronics; Fatty acid glycerol esters; Future; Generations; Gold; Hemoglobin; Hybrids; Hypoxia; Image; Imaging technology; Ionizing radiation; Lasers; Lesion; Lighting; Location; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Neoplasms; Mammography; Maps; Marriage; Measures; Methods; Modality; Modeling; Molecular; Monitor; Noise; Optics; Oxygen; Palpable; Patients; Performance; Physiologic pulse; Powder dose form; Property; ROC Curve; Resolution; Sampling; Schedule; Sensitivity and Specificity; Shapes; Signal Transduction; Specificity; Speed; Staging; System; Systems Development; Technology; Testing; Three-Dimensional Imaging; Tissues; Transducers; Tumor Angiogenesis; Ultrasonic Transducer; Ultrasonics; Ultrasonography; Variant; Vinyl Chloride; Water; Woman; absorption; angiogenesis; attenuation; base; breast lesion; cancer care; cancer imaging; cancer therapy; density; design; energy density; human subject; image reconstruction; imaging modality; imaging probe; improved; malignant breast neoplasm; molecular imaging; mortality; new technology; novel; public health relevance; reconstruction; response; screening; sound; tissue phantom; tomography; tool; tumor; young woman

DESCRIPTION (provided by applicant): "Multimode Laser Optoacoustic Tomography System for Breast Cancer Care" The broad objective of the proposed project is to overcome the limitations of current breast imaging methods by developing a novel multimode three-dimensional (3D) breast imager that generates 5 different images based on optoacoustic tomography (OAT) and laser ultrasound tomography (UST). The rationale for combining OAT and laser UST into a multimode breast imaging method is clear and compelling, since both, OAT and UST are individually receiving significant attention as promising breast cancer imaging methods. OAT can provide two types of images: (1) image of the total hemoglobin associated with density of tumor angiogenesis and (2) image of blood oxygen saturation. This functional (molecular) information related to breast tissue blood content can help to detect early but aggressively growing breast tumors that are hard to detect with (x-ray) mammography, especially in radiologically dense breasts of younger women. On the other hand, UST can provide high-resolution anatomical images of breast lesions based on three complementary acoustic properties (1) speed-of-sound (SOS), (2) acoustic attenuation, and (3) ultrasound reflectivity. By combining OAT and laser UST we will establish an imaging system that can provide comprehensive co- registered functional and anatomical information without the need for breast compression, ionizing radiation, or contrast agents. Furthermore, using laser generation of ultrasound we will significantly improve performance (sensitivity and resolution) of the ultrasound tomography. Our hypothesis is that coregistration and correlation of 5 different images, the proposed imaging technology will provide ultimate sensitivity and specificity. When clinically validated, the new multimode 3D imaging technology will transform breast cancer care by providing not only a better screening (detection) method, but also will serve as a highly effective tool for differentiation and characterization of breast tumors, a feature critical for diagnostics and monitoring the immediate effects of various anticancer therapies. In this project, we will develop technology (system hardware and software algorithms) and test this multi-modality imager in clinical studies on patients present with small size non- palpable breast tumors suspicious for malignancy. The Specific Aims of the project are: (1) Develop, fabricate and implement an optoacoustic plus laser ultrasonic 3D tomography imager based on rotating arc-shaped array of ultrawide-band ultrasonic transducers, (2) Develop and evaluate robust OAT image reconstruction methods for use with the developed imager, (3) Develop 3D ultrasound and multimode (OAT+UST) image reconstruction methods for use with the developed imager, and (4) experimentally validate the imaging system using breast mimicking phantoms and 96 human subjects. The successful completion of the project will produce conclusive data to motivate a systematic multicenter appropriately statistically powered FDA-guided study to evaluate the effectiveness of the developed system and determine the full range of clinical indications.

描述（由申请人提供）：“用于乳腺癌护理的多模式激光光声断层扫描系统” 拟议项目的总体目标是通过开发一种新型多模式三维（3D）乳房成像仪来克服当前乳腺成像方法的局限性，该成像仪基于光声断层扫描（OAT）和激光超声断层扫描（UST）生成5种不同的图像。将 OAT 和激光 UST 结合到多模式乳腺成像方法中的理由是明确且令人信服的，因为 OAT 和 UST 作为有前途的乳腺癌成像方法分别受到了极大的关注。 OAT可以提供两种类型的图像：（1）与肿瘤血管生成密度相关的总血红蛋白图像和（2）血氧饱和度图像。这种与乳腺组织血液含量相关的功能（分子）信息可以帮助检测早期但生长迅速的乳腺肿瘤，而这些肿瘤很难通过（X射线）乳房X线照相术检测到，特别是在年轻女性放射致密的乳房中。另一方面，UST 可以基于三种互补的声学特性（1）声速（SOS）、（2）声衰减和（3）超声反射率提供乳腺病变的高分辨率解剖图像。通过结合 OAT 和激光 UST，我们将建立一个成像系统，可以提供全面的共同配准功能和解剖信息，而无需乳房压缩、电离辐射或造影剂。此外，利用激光产生超声波，我们将显着提高超声波断层扫描的性能（灵敏度和分辨率）。我们的假设是，5 个不同图像的配准和关联，所提出的成像技术将提供最终的灵敏度和特异性。经过临床验证后，新的多模式 3D 成像技术将改变乳腺癌护理，不仅提供更好的筛查（检测）方法，而且还将作为乳腺肿瘤分化和表征的高效工具，这一功能对于诊断和监测各种抗癌疗法的即时效果至关重要。在这个项目中，我们将开发技术（系统硬件和软件算法），并在临床研究中对患有可疑恶性肿瘤的小尺寸不可触及乳腺肿瘤的患者测试这种多模态成像仪。该项目的具体目标是：(1) 开发、制造和实现基于超宽带超声换能器旋转弧形阵列的光声加激光超声 3D 断层扫描成像仪，(2) 开发和评估鲁棒的 OAT 图像重建方法，以与所开发的成像仪一起使用，(3) 开发 3D 超声和多模 (OAT+UST) 图像重建方法，以与 开发了成像仪，(4) 使用模仿乳房的模型和 96 名人类受试者对成像系统进行实验验证。该项目的成功完成将产生结论性数据，以推动 FDA 指导下的系统性多中心、适当统计支持的研究，以评估所开发系统的有效性并确定全方位的临床适应症。