Biobehavioral characterization of infant rhesus monkeys

描述（由申请人提供）：三十年来对啮齿动物、非人类灵长类动物和人类的心理生物学研究已经记录了在气质、情感、行为和生理反应以及个性方面存在的个体差异，我们将其称为生物行为组织。这些特征影响着个体对环境的适应方式，有证据表明，动物的适应质量与心理和生理健康指数有关。在加州国家灵长类动物研究中心，我们开发了一个项目来评估婴儿恒河猴的生物行为组织。我们的方案包括：a)收集在几种情况下的行为数据，旨在评估记忆，对轻微挑战的反应，以及与新物体互动的意愿；b) 5 -羟色胺转运体和单胺氧化酶- a两种神经精神基因启动子区域多态性的基因分型；C)评估下丘脑-垂体-肾上腺系统的调节；d)常规血液学参数测定。所有CNPRC的服务人员和科研人员都可以通过网络界面获取该资源的数据，用于科学和种群管理目的。在目前的申请中，我们提出了以下具体目标：继续每年对大约300只恒河猴幼猴进行生物行为评估，并在每年数据处理完成后，通过我们的网页将这些数据提供给合格的科学和管理人员；继续我们正在进行的努力，以确定我们的BBA项目的前参与者的属性，这些属性面临着对圈养环境适应不良的风险

DESCRIPTION (provided by applicant): Three decades of psychobiological research with rodents, nonhuman primates, and humans have documented the existence of individual differences in temperament, emotionality, behavioral and physiological reactivity, and personality, which we refer to as biobehavioral organization. These characteristics influence an individual's style of adaptation to its environment, and evidence shows that the quality of the animal's adaptations is associated with indices of psychological and physical health. At the California National Primate Research Center, we have developed a program to assess biobehavioral organization in infant rhesus monkeys. Our protocol includes a) collecting behavioral data in several situations designed to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects; b) genotyping for polymorphisms in the promoter regions of two neuropsychiatric genes, the serotonin transporter and monoamine oxidase-A; c) assessing regulation of the hypothalamic-pituitary-adrenal system; and d) measuring routine hematologic parameters. Data from this resource are available to all CNPRC service and scientific staff via a web interface, to use for scientific and colony management purposes. In the current application, we propose the following specific aims: to continue performing our BioBehavioral Assessment on approximately 300 infant rhesus monkeys per year and to make these data available to qualified scientific and management staff through our web page as soon as the processing of the data is complete each year; to continue our ongoing efforts to identify the attributes of former participants in our BBA program that are at risk for poor adaptation to a captive environment as indexed by measures of chronic illness, abnormal behaviors, poor reproduction, and aberrant social function; to use existing statistical methods on our BBA data to establish individual profiles associated with poor outcomes as aids to colony management personnel to prevent health, behavioral, reproductive, and social problems; to continue to develop standardized tests that are shorter, simpler, and easier to administer than our current procedure, yet meet the same standards of reliability and predictive validity for our outcome measures. PUBLIC HEALTH RELEVANCE (provided by applicant): This project will result in improved nonhuman primate models for health-related research, and will provide a database that will be uniquely able to contribute to the development of primate models of personalized medicine.