Core M: POPULATION PHARMACOLOGY

创新 这项研究的目的是创建一套严格的、以人群为基础的案例研究对象 两年内前瞻性收集的心肌梗塞，以及一组没有心肌梗塞的对照受试者。使用 NSAID暴露的程度和类型是一个如此关键的变量，我们建议未来的研究对象 集合，从而能够更准确地回忆最近使用的非甾体抗炎药，以及准确地描述 其他已知的心脏危险因素，基于患者面谈和医疗记录审查。尿液和血液 将收集所有研究对象的样本。但是，经过初步处理后，这些数据的分析 分子特征分析核心的样本将根据 其他核心，如总体研究战略中所述，其中其他研究旨在作为假设 生成，这项研究将准备进行假设检验，建立数据和样本的反应能力 让我们很快来看看这一核心和其他研究中出现的假设。

Innovation The purpose of this study is to create a rigorous and population-based set of case study subjects admitted with an MI, collected prospectively over 2 years, along with a set of control subjects who have not had an MI. With degree and type of NSAID exposure being such a critical variable, we are proposing prospective subject collection, enabling more accurate recall of recently used NSAIDs as well as an accurate characterization of other known cardiac risk factors based on patient interviews and review of medical records. Urine and blood specimens will be collected on all study subjects. However, after initial processing the analyses of these specimens by the Molecular Profiling Core will be deliberately conducted as determined by the outputs of the other Cores, as described in the Overall Research Strategy, where other studies are intended as hypothesis generating, this study will be poised to be hypothesis testing, building the data and specimen capability to react quickly to the hypotheses emerging from other studies in this core and others.