Center for Education and Research in Therapeutics

治疗学教育与研究中心

基本信息

  • 批准号:
    7626236
  • 负责人:
  • 金额:
    $ 110.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-30 至 2011-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Advancing pharmaceutical effectiveness and safety in the United States requires reliable information regarding patterns of pharmaceutical use. The need for better information is particularly pressing regarding pediatric inpatient pharmaceuticals and over-the-counter (OTC) products, especially acetaminophen (APAP) (RFA-HS-08-005, Topic Area 4: Characterization of Key National Drug Use Scenarios). In a joint collaboration of the Centers for Education and Research on Therapeutics at The University of Pennsylvania and the M.D. Anderson Cancer Center, we propose to a) combine detailed but under-utilized existing large datasets and b) collect new primary data, which together will advance our ability to describe, study, and understand the effectiveness and safety of pharmaceuticals received by pediatric patients in hospitals, and how to improve the safe use of OTC APAP in home settings. The work we propose is divided into 2 projects. In Project I, our specific aims are to 1) Determine the rate of use of all pharmaceuticals used during pediatric hospitalizations in 2 large pediatric hospitalization databases containing pharmacy data, specifically the Pediatric Health Information System (PHIS) and Premier datasets; 2) Describe hospital-day specific rates of use, hospital day of first exposure to a drug, and concomitant drug exposures for the most commonly used drugs; 3) Use the nationally representative H-CUP Kids Inpatient Database to assess potential bias in the estimated rates of use of drugs used during pediatric hospitalizations based on the PHIS and Premier datasets; and 4) Examine among a cohort of children hospitalized for APAP overdose the patterns of receipt of an APAP overdose antidote the dose of which is titrated depending upon the extent of liver injury, thus providing a sign of the severity of APAP toxicity. Project II will be conducted in 3 phases. First, we will use focus groups to qualitatively explore knowledge, attitudes, beliefs, and practices of 5) a broadly representative sample of adults and adolescents regarding self-administration of OTC APAP, and parental administration of OTC APAP to children, and 6) a sample of key professional informants, including physician and pharmacists, with respect to communicating information on the administration and risks of OTC APAP to consumers and patients. Second, in phase 2, we will conduct a cross-sectional split-sample experimental survey to 7) estimate frequency of use, knowledge, and practices regarding use of OTC acetaminophen, and evaluate potential determinants of misuse in community-based samples. In Phase 3, we will 8) review medical records of Emergency Room visits to ascertain which events surround APAP overdosing.
描述(由申请人提供):在美国提高药品的有效性和安全性需要有关药品使用模式的可靠信息。关于儿科住院药品和非处方药,特别是对乙酰氨基酚(APAP),尤其迫切需要更好的信息(RFA-HS-08-005,专题领域4:国家主要药物使用情景的特征)。在宾夕法尼亚大学治疗教育和研究中心和M.D.安德森癌症中心的联合合作中,我们建议a)将详细但未得到充分利用的现有大型数据集和b) 收集新的原始数据,这些数据将共同提高我们描述、研究和理解 医院儿科患者用药的有效性和安全性,以及如何提高非处方药APAP在家庭环境中的安全使用。我们提出的工作分为两个项目。在项目I中,我们的具体目标是1)在两个包含药学数据的大型儿科住院数据库中确定儿科住院期间使用的所有药物的使用率,特别是儿科健康信息系统(PHIS)和Premier数据集;2)描述住院日的具体使用率、首次接触药物的住院天数以及最常用药物的伴随药物暴露;3)使用具有全国代表性的H-Cup儿童住院数据库来评估基于PHIS和Premier数据集估计的儿科住院期间药物使用率的潜在偏差;以及4)在一组因APAP过量而住院的儿童中,检查APAP过量解毒剂的接受模式,其剂量根据肝脏损伤的程度进行滴定,从而提供APAP毒性的严重程度的迹象。项目二将分三个阶段进行。首先,我们将使用焦点小组定性地探索以下人群的知识、态度、信念和做法:5)具有广泛代表性的成年人和青少年样本,涉及OTC APAP的自我管理和父母对儿童的OTC APAP管理;6)关键专业信息者的样本,包括医生和药剂师,涉及向消费者和患者沟通OTC APAP的管理和风险的信息。其次,在第二阶段,我们将进行横断面分裂样本实验调查,以7)估计非处方药对乙酰氨基酚的使用频率、知识和做法,并评估社区样本中滥用的潜在决定因素。在第三阶段,我们将回顾急诊室就诊的医疗记录,以确定哪些事件与APAP过量有关。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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BRIAN LESLIE STROM其他文献

BRIAN LESLIE STROM的其他文献

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{{ truncateString('BRIAN LESLIE STROM', 18)}}的其他基金

Comparative Risk of Endometrial Cancer from Ablation Versus Medical Management
子宫内膜癌消融与药物治疗的风险比较
  • 批准号:
    8283124
  • 财政年份:
    2012
  • 资助金额:
    $ 110.47万
  • 项目类别:
Core M: POPULATION PHARMACOLOGY
核心 M:群体药理学
  • 批准号:
    8126773
  • 财政年份:
    2012
  • 资助金额:
    $ 110.47万
  • 项目类别:
Chronic disease clinical epidemiology training in guatemala and peru
危地马拉和秘鲁慢性病临床流行病学培训
  • 批准号:
    8327366
  • 财政年份:
    2010
  • 资助金额:
    $ 110.47万
  • 项目类别:
Chronic disease clinical epidemiology training in guatemala and peru
危地马拉和秘鲁慢性病临床流行病学培训
  • 批准号:
    8100465
  • 财政年份:
    2010
  • 资助金额:
    $ 110.47万
  • 项目类别:
Chronic disease clinical epidemiology training in guatemala and peru
危地马拉和秘鲁慢性病临床流行病学培训
  • 批准号:
    8296175
  • 财政年份:
    2010
  • 资助金额:
    $ 110.47万
  • 项目类别:
Chronic disease clinical epidemiology training in guatemala and peru
危地马拉和秘鲁慢性病临床流行病学培训
  • 批准号:
    7944811
  • 财政年份:
    2010
  • 资助金额:
    $ 110.47万
  • 项目类别:
Neurologic Clinical Epidemiology Training Grant
神经病学临床流行病学培训补助金
  • 批准号:
    8475193
  • 财政年份:
    2008
  • 资助金额:
    $ 110.47万
  • 项目类别:
Neurologic Clinical Epidemiology Training Program
神经病学临床流行病学培训计划
  • 批准号:
    8264979
  • 财政年份:
    2008
  • 资助金额:
    $ 110.47万
  • 项目类别:
Clinical importance of the drug interaction between statins and SYP3A inhibitors
他汀类药物与 SYP3A 抑制剂之间药物相互作用的临床重要性
  • 批准号:
    7633266
  • 财政年份:
    2008
  • 资助金额:
    $ 110.47万
  • 项目类别:
Center For Education and Research in Therapeutics
治疗学教育与研究中心
  • 批准号:
    7898829
  • 财政年份:
    2007
  • 资助金额:
    $ 110.47万
  • 项目类别:

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