Research Training in Blood Diseases and Resources

描述(申请人提供)：血液学，研究正常和疾病的血液成分及其与其所在的血管系统的相互作用，是一个肥沃的研究领域，在很大程度上是由于血液学研究人员对初级组织的令人羡慕的访问。尽管如此，尽管我们在了解各种血液疾病的分子基础方面取得了显著突破，但我们目前的知识与我们从实质上改变这些疾病进程的能力之间仍然存在差距。BUSM血液学培训计划(HTP)的目标是吸引有才华的研究人员参与血液学研究项目，激励他们为随后的研究事业选择血液学的某些方面，并为他们提供知识基础、技术技能和拨款撰写能力，以便能够在学术环境中确立自己的独立研究人员地位。我们拟议的培训计划自1980年开始实施，将培训四名博士后学生和四名博士后学生，后者拥有博士(2)或医学博士(2)学位。受训者将由18名教师组成，他们对以下四个领域的研究兴趣特别浓厚：血红蛋白病、免疫疗法和免疫病理学、淋巴细胞信号和基因表达以及血小板和血栓生物学。注册生物化学、微生物学或分子医学等基础科学专业的博士前学生通常在研究生二年级向HTP执行委员会提出申请。博士后和博士后都参加了血液学杂志俱乐部、血液学大班和分子到分子治疗学课程，这是一门深入研究血红蛋白疾病的课程。通过营造临床医生和基础科学研究人员密切合作的氛围，我们的计划将培训下一代血液学研究人员，以确定实用的治疗方法，以弥合我们对血液病分子基础的了解与其成功治疗之间的差距。

Description (provided by applicant): Hematology, the study of normal and diseased blood elements and their interaction with the vasculature in which they reside, is a fertile research field, in no small part due to the enviable access of hematologic researchers to primary tissues. Nonetheless, despite remarkable breakthroughs in our understanding of the molecular basis for a wide variety of hematologic illnesses, there remains a gap between our current knowledge and our ability to substantively alter the course of these diseases. The goals of the BUSM Hematology Training Program (HTP) are to attract talented researchers to a hematologic research project, to inspire them to choose some aspect of hematology for their subsequent research careers, and to give them the knowledge base, the technical skills and the grant-writing ability to be able to establish themselves as independent researchers in an academic setting. Our proposed training program, which has been existence since 1980, will train four pre-doctoral students and four post-doctoral students, the latter with either PhD (2) or MD (2) degrees. Trainees will be mentored by a select group of 18 faculty whose research interests are particularly strong in the following four areas: Hemoglobinopathies, Immunotherapy and Immunopathology, Lymphoid Cell Signaling and Gene Expression, and Platelet and Thrombosis Biology. Pre-doctoral students enrolled in established basic science programs such as Biochemistry, Microbiology or Molecular Medicine typically apply to the HTP executive committee during their second year of graduate school. Both pre-doctoral students and post- doctoral fellows attend Hematology Journal Club, Hematology Grand Rounds and a Molecules to Molecular Therapeutics course which is an in depth study of hemoglobinopathies. By fostering an atmosphere in which clinicians and basic science researchers work in close collaboration, our program will train the next generation of hematology researchers to identify practical therapeutic approaches that will close the gap between our knowledge of the molecular basis for hematologic illness and its successful treatment.