Omics of Lung Diseases

描述(由申请人提供)：这项新的K12提案要求支持1-2年的工资支持，以培养具有结合计算科学和肺部医学的技能的独立调查人员。医学博士、博士或医学博士/博士候选人将根据他们对生物医学研究事业的承诺、他们在学术和医学培训方面的卓越表现以及他们对肺部疾病的兴趣来招募，并在一个项目中接受指导，该项目将在辛辛那提大学医学院(UCCOM)、辛辛那提大学工程学院(UC)和辛辛那提儿童医院医学中心(CCHMC)提供生物医学信息学和“组学”方面的专业知识。学者计划将提供教学经验、研究培训和职业道路支持，以优化他们作为独立调查人员的发展，使他们拥有将“组学”应用于肺部疾病所需的综合技能。该计划汇集了高度投入的培训教师，该计划将把儿科和成人肺部医学方面的杰出临床医生和科学家专家与环境健康、肺部生物学、生物工程、生物信息学和其他计算科学方面的科学家整合在一起。蛋白质组学、基因组学、临床生物信息学、脂类组学、代谢组学和遗传学的使用和解释将为培训经验提供框架。该计划的目标是：1)吸引、招募和促进“肺部组学”计划的最高素质申请者的职业发展，包括代表性不足的少数族裔；2)进一步开发和应用一个高度组织的培训计划，将教学和直接研究经验纳入课程，将肺部生物学和医学知识与计算和技术技能联系起来，为肺部研究人员未来的生物医学和内科科学家职业生涯提供最佳培训；以及3)培训和发展将成为肺部医学领域领导者的研究人员的职业道路。理由：在定量生物医学科学和肺部疾病方面受过良好培训的年轻研究人员迫切需要职业发展。使能技术的迅速扩展，无论是在临床数据库、生物信息学、流行病学、基因组学、表观遗传学、蛋白质科学和新陈代谢方面，都为增进与肺部医学有关的知识创造了无与伦比的机会。选择医学和生物研究的年轻研究人员的培训经验和气质往往与选择以计算为基础的科学的人截然不同。越来越明显的是，高通量技术和计算能力的进步为协同发现提供了肥沃的支持，这些发现将改变诊断和治疗 肺部疾病。目前的K12应用程序寻求为职业发展创造跨学科的机会，将与高通量平台相关的计算科学和技术与肺部医学和生物学联系起来。

DESCRIPTION (provided by applicant): This new K12 proposal requests support for 1-2 years of salary support to develop independent investigators with skills that integrate computational sciences and pulmonary medicine. M.D., Ph.D. or M.D./Ph.D. candidates will be recruited based on their commitments to biomedical research careers, their excellence in scholarly and medical training, and their interest in pulmonary disease, to be mentored in a program that will provide expertise in biomedical informatics and the "omics" at the University of Cincinnati College of Medicine (UCCOM), the University of Cincinnati School of Engineering (UC), and Cincinnati Children's Hospital Medical Center (CCHMC). The scholars program will provide didactic experience, research training, and career pathway support to optimize their development as independent investigators with the integrated skills needed to apply the "omics" to pulmonary disease. The program brings together highly a committed training faculty within a program that will integrate outstanding clinician-scientists expert in pediatric and adult pulmonary medicine, with scientists in environmental health, pulmonary biology, bioengineering, bioinformatics, and other computational science. Use and interpretation of proteomics, genomics, clinical bioinformatics, lipidomics, metabolomics, and genetics will provide the framework for the training experience. Program Aims: 1) Attract, recruit, and advance career development of the highest quality applicants to the "pulmonary omics" program, including underrepresented minorities; 2) To further develop and apply a highly organized training program that will include didactic and direct research experience in a curriculum that will bridge knowledge regarding pulmonary biology and medicine with computational and technological skills that are needed to optimally train the pulmonary investigators for their future careers as biomedical and physician-scientists; and 3) To train and develop career paths for investigators who will become leaders in the field of pulmonary medicine. Rationale: There is compelling need for career development of young investigators who are well trained in quantitative biomedical sciences and pulmonary disease. Rapid expansion of enabling technologies, whether in use of clinical databases, bioinformatics, epidemiology, genomics, epigenetics, protein sciences and metabolism, has created unparalleled opportunities to advance knowledge related to pulmonary medicine. The training experience and temperament of young investigators choosing medical and biological research are often quite distinct from those choosing computational-based sciences. It is increasingly apparent that advances in high-throughput technology and computational abilities provide fertile support for synergizing discoveries that will transform the diagnosis and treatment of pulmonary disease. The present K12 application seeks to create transdisciplinary opportunities for career development, bridging computational sciences and technology related to high-throughput platforms with pulmonary medicine and biology.