Omics of Lung Diseases

描述（由申请人提供）：这项新的K1 - 2提案要求提供1-2年的工资支持，以培养具有整合计算科学和肺部医学技能的独立研究人员。医学博士，博士或医学博士/博士候选人将根据他们对生物医学研究事业的承诺、他们在学术和医学培训方面的卓越表现以及他们对肺部疾病的兴趣被招募，并在辛辛那提大学医学院（UCCOM）、辛辛那提大学工程学院（UC）、和辛辛那提儿童医院医疗中心（CCHMC）。学者计划将提供教学经验，研究培训和职业途径支持，以优化他们作为独立研究者的发展，并具备将“组学”应用于肺部疾病所需的综合技能。该计划汇集了一个高度致力于培训的教师，该计划将整合儿科和成人肺部医学的杰出临床医生-科学家专家，以及环境健康，肺生物学，生物工程，生物信息学和其他计算科学的科学家。蛋白质组学、基因组学、临床生物信息学、脂质组学、代谢组学和遗传学的使用和解释将为培训经验提供框架。方案目标：1）吸引，招募和推进最高质量的申请人的职业发展“肺组学”计划，包括代表性不足的少数民族;（二）为了进一步开发和应用一个高度组织化的培训计划，该计划将包括课程中的教学和直接研究经验，该课程将把有关肺生物学和医学的知识与最佳培训所需的计算和技术技能联系起来。肺研究人员为他们未来的职业生涯作为生物医学和医生科学家;和3）培训和发展的研究人员谁将成为领导者在肺医学领域的职业道路。基本原理：迫切需要在定量生物医学科学和肺部疾病方面受过良好培训的年轻研究人员的职业发展。无论是在临床数据库、生物信息学、流行病学、基因组学、表观遗传学、蛋白质科学和代谢方面，使能技术的迅速发展都为推进与肺部医学相关的知识创造了前所未有的机会。选择医学和生物学研究的年轻研究人员的培训经验和气质往往与选择基于计算的科学的人截然不同。越来越明显的是，高通量技术和计算能力的进步为将改变诊断和治疗的协同发现提供了丰富的支持 肺部疾病。目前的K12申请旨在为职业发展创造跨学科的机会，将与高通量平台相关的计算科学和技术与肺部医学和生物学联系起来。

DESCRIPTION (provided by applicant): This new K12 proposal requests support for 1-2 years of salary support to develop independent investigators with skills that integrate computational sciences and pulmonary medicine. M.D., Ph.D. or M.D./Ph.D. candidates will be recruited based on their commitments to biomedical research careers, their excellence in scholarly and medical training, and their interest in pulmonary disease, to be mentored in a program that will provide expertise in biomedical informatics and the "omics" at the University of Cincinnati College of Medicine (UCCOM), the University of Cincinnati School of Engineering (UC), and Cincinnati Children's Hospital Medical Center (CCHMC). The scholars program will provide didactic experience, research training, and career pathway support to optimize their development as independent investigators with the integrated skills needed to apply the "omics" to pulmonary disease. The program brings together highly a committed training faculty within a program that will integrate outstanding clinician-scientists expert in pediatric and adult pulmonary medicine, with scientists in environmental health, pulmonary biology, bioengineering, bioinformatics, and other computational science. Use and interpretation of proteomics, genomics, clinical bioinformatics, lipidomics, metabolomics, and genetics will provide the framework for the training experience. Program Aims: 1) Attract, recruit, and advance career development of the highest quality applicants to the "pulmonary omics" program, including underrepresented minorities; 2) To further develop and apply a highly organized training program that will include didactic and direct research experience in a curriculum that will bridge knowledge regarding pulmonary biology and medicine with computational and technological skills that are needed to optimally train the pulmonary investigators for their future careers as biomedical and physician-scientists; and 3) To train and develop career paths for investigators who will become leaders in the field of pulmonary medicine. Rationale: There is compelling need for career development of young investigators who are well trained in quantitative biomedical sciences and pulmonary disease. Rapid expansion of enabling technologies, whether in use of clinical databases, bioinformatics, epidemiology, genomics, epigenetics, protein sciences and metabolism, has created unparalleled opportunities to advance knowledge related to pulmonary medicine. The training experience and temperament of young investigators choosing medical and biological research are often quite distinct from those choosing computational-based sciences. It is increasingly apparent that advances in high-throughput technology and computational abilities provide fertile support for synergizing discoveries that will transform the diagnosis and treatment of pulmonary disease. The present K12 application seeks to create transdisciplinary opportunities for career development, bridging computational sciences and technology related to high-throughput platforms with pulmonary medicine and biology.