Omics of Lung Diseases

肺部疾病组学

• 批准号: 8574590
• 负责人: Jeffrey A Whitsett
• 金额: $ 12.42万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8574590
• 关键词: Adult; Bioinformatics; Biology; Biomedical Engineering; Biomedical Research; Childhood; Clinical; Commit; Computational Science; Databases; Development; Diagnosis; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Engineering; Environmental Health; Epidemiology; Epigenetic Process; Faculty; Future; Genetic; Genomics; Knowledge; Lung; Lung diseases; Medical; Medical Research; Medical center; Medicine; Mentors; Metabolism; NCI Scholars Program; Pathway interactions; Pediatric Hospitals; Physicians; Proteins; Proteomics; Pulmonology; Recruitment Activity; Request for Proposals; Research; Research Personnel; Research Training; SECTM1 gene; Schools; Science; Scientist; Technology; Temperament; Training; Training Programs; Underrepresented Minority; Universities; Wages; base; biological research; biomedical informatics; career; career development; college; experience; high throughput technology; interest; metabolomics; programs; skills

DESCRIPTION (provided by applicant): This new K12 proposal requests support for 1-2 years of salary support to develop independent investigators with skills that integrate computational sciences and pulmonary medicine. M.D., Ph.D. or M.D./Ph.D. candidates will be recruited based on their commitments to biomedical research careers, their excellence in scholarly and medical training, and their interest in pulmonary disease, to be mentored in a program that will provide expertise in biomedical informatics and the "omics" at the University of Cincinnati College of Medicine (UCCOM), the University of Cincinnati School of Engineering (UC), and Cincinnati Children's Hospital Medical Center (CCHMC). The scholars program will provide didactic experience, research training, and career pathway support to optimize their development as independent investigators with the integrated skills needed to apply the "omics" to pulmonary disease. The program brings together highly a committed training faculty within a program that will integrate outstanding clinician-scientists expert in pediatric and adult pulmonary medicine, with scientists in environmental health, pulmonary biology, bioengineering, bioinformatics, and other computational science. Use and interpretation of proteomics, genomics, clinical bioinformatics, lipidomics, metabolomics, and genetics will provide the framework for the training experience. Program Aims: 1) Attract, recruit, and advance career development of the highest quality applicants to the "pulmonary omics" program, including underrepresented minorities; 2) To further develop and apply a highly organized training program that will include didactic and direct research experience in a curriculum that will bridge knowledge regarding pulmonary biology and medicine with computational and technological skills that are needed to optimally train the pulmonary investigators for their future careers as biomedical and physician-scientists; and 3) To train and develop career paths for investigators who will become leaders in the field of pulmonary medicine. Rationale: There is compelling need for career development of young investigators who are well trained in quantitative biomedical sciences and pulmonary disease. Rapid expansion of enabling technologies, whether in use of clinical databases, bioinformatics, epidemiology, genomics, epigenetics, protein sciences and metabolism, has created unparalleled opportunities to advance knowledge related to pulmonary medicine. The training experience and temperament of young investigators choosing medical and biological research are often quite distinct from those choosing computational-based sciences. It is increasingly apparent that advances in high-throughput technology and computational abilities provide fertile support for synergizing discoveries that will transform the diagnosis and treatment of pulmonary disease. The present K12 application seeks to create transdisciplinary opportunities for career development, bridging computational sciences and technology related to high-throughput platforms with pulmonary medicine and biology.

描述（由申请人提供）：这一新的K12提案要求为1 - 2年的薪水支持提供支持，以开发独立的研究人员，并具有整合计算科学和肺部医学的技能。医学博士或M.D./PH.D。候选人将根据他们对生物医学研究职业的承诺，学术和医学培训的卓越性以及对肺部疾病的兴趣的招聘，并将在一项计划中指导，该计划将在辛辛那提大学医学院（UCCOM），辛辛那提大学（UCCINNATI SCORPEN），Engionering（Ucinnati Sempleering）（UCINS）（UCINS）（UCNERIENER EYCERIENINE）（UCING）和辛辛那提大学（UCCINNATI SEOCRATION）的生物医学信息学和“ OMICS”方面的专业知识。 （CCHMC）。学者计划将提供教学经验，研究培训和职业途径支持，以优化其作为独立研究人员的发展，并具有将“ OMIC”应用于肺部疾病所需的综合技能。该计划将高度致力于的培训学院召集在一项计划中，该计划将与杰出的临床医生科学家在儿科和成人肺医学领域结合，并与环境健康，肺部生物学，生物工程，生物信息学和其他计算科学领域的科学家。蛋白质组学，基因组学，临床生物信息学，脂质组学，代谢组学和遗传学的使用和解释将为培训经验提供框架。计划的目的：1）吸引，招募和推进最高质量申请人的职业发展，其中包括代表性不足的少数群体； 2）进一步开发和应用高度有条理的培训计划，该计划将包括课程中的教学和直接研究经验，该课程将以计算和技术技能桥接有关肺部生物学和医学的知识，以最佳的方式培训肺部研究人员，以培训肺部研究人员的未来职业，以作为其生物医学和医师科学家的未来职业； 3）训练和发展职业道路，为将成为肺部医学领域领导者的调查人员的职业道路。理由：在定量生物医学和肺部疾病中接受良好培训的年轻研究人员的职业发展迫切需要。在使用临床数据库，生物信息学，流行病学，基因组学，表观遗传学，蛋白质科学和代谢方面，促成技术的快速扩展都为促进与肺部医学相关的知识创造了无与伦比的机会。选择医学和生物学研究的年轻研究人员的培训经验和气质通常与选择基于计算的科学的人完全不同。越来越明显的是，高通量技术和计算能力的进步为协同性发现提供了肥沃的支持，这些发现将改变诊断和治疗 肺部疾病。目前的K12应用程序旨在为职业发展创造跨学科的机会，桥接与肺部医学和生物学的高通量平台相关的计算科学和技术。