Omics of Lung Diseases

描述（由申请人提供）：这个新的K12提案要求支持1-2年的薪资支持，以培养具有整合计算科学和肺部医学技能的独立研究者。M.D.， phd或M.D./Ph.D。候选人将根据其对生物医学研究事业的承诺、在学术和医学培训方面的卓越表现以及对肺部疾病的兴趣被招募，并在辛辛那提大学医学院（UCCOM）、辛辛那提大学工程学院（UC）和辛辛那提儿童医院医学中心（CCHMC）的一个项目中接受指导，该项目将提供生物医学信息学和“组学”方面的专业知识。该学者项目将提供教学经验、研究培训和职业路径支持，以优化他们作为独立研究者的发展，并具备将“组学”应用于肺部疾病所需的综合技能。该项目将儿科和成人肺部医学领域的杰出临床医生和科学家与环境健康、肺部生物学、生物工程、生物信息学和其他计算科学领域的科学家结合在一起。蛋白质组学、基因组学、临床生物信息学、脂质组学、代谢组学和遗传学的使用和解释将为培训经验提供框架。项目目标：1)吸引、招募并促进“肺组学”项目最优秀申请者的职业发展，包括少数族裔；2)进一步发展和应用一个高度组织的培训计划，该计划将在课程中包括教学和直接研究经验，将肺部生物学和医学知识与计算和技术技能相结合，以最佳方式培训肺部调查员，为他们未来的生物医学和内科科学家的职业生涯做好准备；3)培养和发展将成为肺医学领域领导者的研究人员的职业道路。理由：迫切需要在定量生物医学科学和肺部疾病方面受过良好训练的年轻研究人员的职业发展。无论是在临床数据库、生物信息学、流行病学、基因组学、表观遗传学、蛋白质科学和代谢方面的应用，使能技术的迅速发展为推进与肺医学相关的知识创造了无与伦比的机会。选择医学和生物学研究的年轻研究人员的训练经历和气质往往与选择基于计算的科学的研究人员截然不同。越来越明显的是，高通量技术和计算能力的进步为协同发现提供了丰富的支持，这些发现将改变诊断和治疗

DESCRIPTION (provided by applicant): This new K12 proposal requests support for 1-2 years of salary support to develop independent investigators with skills that integrate computational sciences and pulmonary medicine. M.D., Ph.D. or M.D./Ph.D. candidates will be recruited based on their commitments to biomedical research careers, their excellence in scholarly and medical training, and their interest in pulmonary disease, to be mentored in a program that will provide expertise in biomedical informatics and the "omics" at the University of Cincinnati College of Medicine (UCCOM), the University of Cincinnati School of Engineering (UC), and Cincinnati Children's Hospital Medical Center (CCHMC). The scholars program will provide didactic experience, research training, and career pathway support to optimize their development as independent investigators with the integrated skills needed to apply the "omics" to pulmonary disease. The program brings together highly a committed training faculty within a program that will integrate outstanding clinician-scientists expert in pediatric and adult pulmonary medicine, with scientists in environmental health, pulmonary biology, bioengineering, bioinformatics, and other computational science. Use and interpretation of proteomics, genomics, clinical bioinformatics, lipidomics, metabolomics, and genetics will provide the framework for the training experience. Program Aims: 1) Attract, recruit, and advance career development of the highest quality applicants to the "pulmonary omics" program, including underrepresented minorities; 2) To further develop and apply a highly organized training program that will include didactic and direct research experience in a curriculum that will bridge knowledge regarding pulmonary biology and medicine with computational and technological skills that are needed to optimally train the pulmonary investigators for their future careers as biomedical and physician-scientists; and 3) To train and develop career paths for investigators who will become leaders in the field of pulmonary medicine. Rationale: There is compelling need for career development of young investigators who are well trained in quantitative biomedical sciences and pulmonary disease. Rapid expansion of enabling technologies, whether in use of clinical databases, bioinformatics, epidemiology, genomics, epigenetics, protein sciences and metabolism, has created unparalleled opportunities to advance knowledge related to pulmonary medicine. The training experience and temperament of young investigators choosing medical and biological research are often quite distinct from those choosing computational-based sciences. It is increasingly apparent that advances in high-throughput technology and computational abilities provide fertile support for synergizing discoveries that will transform the diagnosis and treatment of pulmonary disease. The present K12 application seeks to create transdisciplinary opportunities for career development, bridging computational sciences and technology related to high-throughput platforms with pulmonary medicine and biology.