SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)
SALsalate 可改善 T2dm-DHF 患者的运动耐受性和 LVDD(SALIENT-DHF 试验)
基本信息
- 批准号:8403729
- 负责人:
- 金额:$ 51.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingActivities of Daily LivingAcuteAnaerobic ThresholdAnti-Inflammatory AgentsAnti-inflammatoryApplications GrantsBlood VesselsCardiologyCardiomyopathiesCardiopulmonaryCardiovascular systemCessation of lifeChronicCitiesClinicalClinical InvestigatorClinical ResearchClinical TrialsCollagenDegenerative polyarthritisDevelopmentDiabetes MellitusDiastolic heart failureDigitalis preparationDouble-Blind MethodEchocardiographyEducational CurriculumEnrollmentExerciseExercise ToleranceExercise stress testFDA approvedFacultyFibrosisFunctional disorderGenderGeneric DrugsHeart HypertrophyHeart failureHospitalizationIndividualInflammationInstructionInsulin ResistanceInvestigationKansasLeadLeadershipLeftMaster of ScienceMeasuresMediatingMentorsMissouriMorbidity - disease rateMyocardialN(6)-carboxymethyllysineNational Heart, Lung, and Blood InstituteNon-Insulin-Dependent Diabetes MellitusOutcomeOxidative StressPathway interactionsPatientsPeroxidasesPharmaceutical PreparationsPhasePlacebo ControlPlacebosQuality of lifeQuestionnairesRandomizedRandomized Clinical TrialsRecruitment ActivityRelaxationResearchResearch DesignResearch Project GrantsRotationSeriesSerum MarkersTestingTimeTrainingUniversitiesVentricularVisitWalkingWashingtonagedbrachial arterycareerclinical research siteglycemic controlhazardhigh riskimprovedimproved functioningindexinginflammatory modulationlecturesmortalitymultidisciplinarypressureprocollagen Type III-N-terminal peptideprocollagen type I carboxy terminal peptideprogramsprospectiveracial and ethnicresponsesalicylsalicylic acidskillssocioeconomicssymposiumtreatment trialtrial comparing
项目摘要
This application in response to RFA-HL-12-001 is to establish a Washington University Heart Failure
Regional Clinical Center (HF-RCC), comprised of 5 clinical sites located throughout the state of Missouri.
The proposed RCC will be capable of recruiting patients from a wide range of socioeconomic, gender,
ethnic, and racial backgrounds, for acute and chronic trials heart failure trials in patients with systolic (SHF)
and diastolic heart failure (DHF). Two additional components of this application are:
A. Proposal for an early-phase randomized clinical trial (RCT) in patients with type 2 diabetes (T2D) and
DHF, using a salsalate (SSA), an anti-inflammatory agent that improves glycemic control in T2D.
The proposed placebo-controlled double-blind RCT in patients with T2D and DHF will test the hypothesis
that modulation of inflammatory pathways by salsalate leads to improved left venricular end-diastolic filling
pressures (detemined by echo-derived indices of LV diastolic function) and improved patient funtional
capacity (determined by V02max).
B. Proposal for a Clinical Research Skills Development Core (CRSDC) to train HF clinical investigators.
There are three major objectives of the CRSDC: 1. Support two CRSDC Scholars/year to undergo training in
clinical HF research by enrolling in a 2-year Masters of Science degree program. Scholars will gain clinical
research skills through coursework, seminars, and one-on-one contact with a multidisciplinary group of
faculty/mentors involved in clinical research. 2. Develop individualized mentored program in clinical HF
research. This will include: a) completion of a mentored clinical HF research project; b) promote scholar
career advancement through mentoring and guidance; c) prepare and submit a grant proposal; and d)
evaluate scholars, mentors and CRSDC program. 3. Implement a HF-specific curriculum: a) weekly CV
seminars; b) quarterly HF lecture series; c) yearly HF symposium; d) HF Visiting Professorship; and e)
optional external rotations.
响应RFA-HL-12-001的本申请旨在建立一个华盛顿大学心力衰竭
区域临床中心(HF-RCC),由遍布密苏里州的5个临床研究中心组成。
拟议的RCC将能够从广泛的社会经济、性别、
种族和人种背景,用于收缩压(SHF)患者的急性和慢性试验心力衰竭试验
舒张性心力衰竭(DHF)。此应用程序的两个附加组件是:
A.在2型糖尿病(T2 D)患者中开展早期随机临床试验(RCT)的提案,
DHF,使用双水杨酸酯(SSA),一种改善T2 D血糖控制的抗炎药。
在T2 D和DHF患者中拟定的安慰剂对照双盲RCT将检验假设
双水杨酸对炎症通路的调节可改善左心室舒张末期充盈
压力(由LV舒张功能的回声衍生指数确定)和改善患者功能
容量(由V02 max确定)。
B。临床研究技能发展核心(CRSDC)培训HF临床研究者的提案。
委员会有三个主要目标:1.每年支持两名CRSDC学者接受以下培训:
通过参加为期2年的理学硕士学位课程进行临床HF研究。学者将获得临床
研究技能,通过课程,研讨会,和一对一的接触与多学科小组的
参与临床研究的教师/导师。2.开展临床心力衰竭的个体化指导计划
research.这将包括:a)完成指导临床HF研究项目; B)促进学者
通过辅导和指导促进职业发展; c)准备并提交赠款提案;以及d)
评估学者,导师和CRSDC计划。3.实施针对保健基金的课程:
研讨会; B)HF季度讲座系列; c)HF年度研讨会; d)HF访问教授;以及e)
可选的外部旋转。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Victor G. Davila-Roman其他文献
NETWORK ANALYSIS OF EPISTATIC INTERACTIONS AMONG FOUR MYOCARDIAL FATTY ACID METABOLISM CANDIDATE GENES MODULATING HYPERTENSIVE HEART DISEASE
- DOI:
10.1016/s0735-1097(10)61227-2 - 发表时间:
2010-03-09 - 期刊:
- 影响因子:
- 作者:
Lisa de las Fuentes;Jyh M. Juang;Sharlee Climer;Victor G. Davila-Roman - 通讯作者:
Victor G. Davila-Roman
PRENATAL ASPIRIN USE IS ASSOCIATED WITH REDUCED INCIDENCE OF POSTPARTUM HYPERTENSION AMONG WOMEN WITH PREECLAMPSIA
- DOI:
10.1016/s0735-1097(20)32468-2 - 发表时间:
2020-03-24 - 期刊:
- 影响因子:
- 作者:
Eleanor Christenson;Molly J. Stout;Dominique Williams;Amanda Verma;Douglas L. Mann;Victor G. Davila-Roman;Kathryn Lindley - 通讯作者:
Kathryn Lindley
A DIET HIGH IN LONG CHAIN FATTY ACIDS WORSENS SYSTOLIC FUNCTION IN TYPE II DIABETIC PATIENTS, BUT A DIET RICH IN MEDIUM CHAIN FATTY ACIDS DOES NOT: A RANDOMIZED, DOUBLE-BLIND STUDY
- DOI:
10.1016/s0735-1097(13)60763-9 - 发表时间:
2013-03-12 - 期刊:
- 影响因子:
- 作者:
Sophia LaHusen-Bair;Andrew R. Coggan;Adil Bashir;Marsha Farmer;Robert O'Connor;Catherine Anderson-Spearie;Alan D. Waggoner;Pamela Woodard;Cylen Javidan;Babak Banan;Kitty Krupp;Victor G. Davila-Roman;Linda R. Peterson - 通讯作者:
Linda R. Peterson
Postoperative myocardial wall stress in patients with chronic aortic insufficiency: Ross procedure versus St. Jude mechanical aortic valve prosthesis
- DOI:
10.1016/s0735-1097(02)81928-3 - 发表时间:
2002-03-06 - 期刊:
- 影响因子:
- 作者:
Pavlos Moustakidis;Brian P. Cupps;Hersh S. Maniar;Giridhar Vedala;Lisa De Las Fuentes;Thoralf M. Sundt;Nicholas T. Kouchoukos;Victor G. Davila-Roman;Michael K. Pasque - 通讯作者:
Michael K. Pasque
SEX, OBESITY AND TYPE 2 DIABETES AFFECT THE INTRAMYOCELLULAR FATE OF GLUCOSE IN HUMANS
- DOI:
10.1016/s0735-1097(11)60689-x - 发表时间:
2011-04-05 - 期刊:
- 影响因子:
- 作者:
Linda Ruth Peterson;Pilar Herrero;C. Huie Lin;Matthew Lyons;Carmen Dence;Zulfia Kisrieva-Ware;Alan D. Waggoner;Victor G. Davila-Roman;Deborah Delano;Robert J. Gropler - 通讯作者:
Robert J. Gropler
Victor G. Davila-Roman的其他文献
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{{ truncateString('Victor G. Davila-Roman', 18)}}的其他基金
SYNthetic Healthcare DAta Platform for Data SciEnce Training ("SYNAPSE")
用于数据科学培训的综合医疗保健数据平台(“SYNAPSE”)
- 批准号:
10717478 - 财政年份:2023
- 资助金额:
$ 51.06万 - 项目类别:
Enhancing Cardiovascular Health Equity in Mothers and Children Through Home Visiting
通过家访提高母亲和儿童的心血管健康公平性
- 批准号:
10618374 - 财政年份:2022
- 资助金额:
$ 51.06万 - 项目类别:
Washington University SummeR reseArch DIversity ProgrAm iN Cardiovascular Disease & HEmatology (RADIANCE)
华盛顿大学心血管疾病夏季研究多样性计划
- 批准号:
10619007 - 财政年份:2022
- 资助金额:
$ 51.06万 - 项目类别:
Enhancing Cardiovascular Health Equity in Mothers and Children Through Home Visiting
通过家访提高母亲和儿童的心血管健康公平性
- 批准号:
10426758 - 财政年份:2022
- 资助金额:
$ 51.06万 - 项目类别:
Research Training in Data Science for Health in Rwanda
卢旺达健康数据科学研究培训
- 批准号:
10490313 - 财政年份:2021
- 资助金额:
$ 51.06万 - 项目类别:
Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru
研究培训:秘鲁的慢性非传染性心血管疾病和合并症
- 批准号:
10483128 - 财政年份:2021
- 资助金额:
$ 51.06万 - 项目类别:
Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru
研究培训:秘鲁的慢性非传染性心血管疾病和合并症
- 批准号:
10308323 - 财政年份:2021
- 资助金额:
$ 51.06万 - 项目类别:
Research Training in Data Science for Health in Rwanda
卢旺达健康数据科学研究培训
- 批准号:
10675593 - 财政年份:2021
- 资助金额:
$ 51.06万 - 项目类别:
Research Training in Data Science for Health in Rwanda
卢旺达健康数据科学研究培训
- 批准号:
10320162 - 财政年份:2021
- 资助金额:
$ 51.06万 - 项目类别:
Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru
研究培训:秘鲁的慢性非传染性心血管疾病和合并症
- 批准号:
10680600 - 财政年份:2021
- 资助金额:
$ 51.06万 - 项目类别:
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