SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)

此应用程序响应RFA-HL-12-001，用于建立华盛顿大学心力衰竭 地区临床中心(HF-RCC)，由密苏里州各地的5个临床站点组成。 拟议的肾癌将能够招募来自广泛的社会经济，性别， 种族和种族背景，用于急性和慢性心力衰竭患者的心脏收缩试验(SHF) 舒张性心力衰竭(DHF)。此应用程序的另外两个组件是： 建议对2型糖尿病患者进行早期随机临床试验(RCT)和 DHF，使用一种水杨酸盐(SSA)，这是一种抗炎剂，可以改善T2D的血糖控制。 建议在T2D和DHF患者中进行的安慰剂对照双盲RCT将检验这一假说 水杨酸盐对炎症通路的调节可改善左室舒张末期充盈 压力(由左室舒张功能的回声指数决定)和改善的患者功能 容量(由V02max确定)。 B.关于建立临床研究技能发展核心(CRSDC)以培训心力衰竭临床研究人员的建议。 CRSDC有三个主要目标：1.每年支持两名CRSDC学者接受培训 通过注册一个两年制的科学硕士学位课程进行临床心力衰竭研究。学者们将获得临床经验 通过课程作业、研讨会和与多学科小组的一对一接触获得研究技能 参与临床研究的教师/导师。2.制定临床心衰个体化带教方案 研究。这将包括：a)完成指导的临床心衰研究项目；b)促进学者 通过指导和指导促进职业发展；c)编写并提交赠款提案；d) 评估学者、导师和CRSDC计划。3.实施专门针对HF的课程：a)每周简历 研讨会；b)高频季刊系列讲座；c)年度高频研讨会；d)高频客座教授；e) 可选的外部旋转。

This application in response to RFA-HL-12-001 is to establish a Washington University Heart Failure Regional Clinical Center (HF-RCC), comprised of 5 clinical sites located throughout the state of Missouri. The proposed RCC will be capable of recruiting patients from a wide range of socioeconomic, gender, ethnic, and racial backgrounds, for acute and chronic trials heart failure trials in patients with systolic (SHF) and diastolic heart failure (DHF). Two additional components of this application are: A. Proposal for an early-phase randomized clinical trial (RCT) in patients with type 2 diabetes (T2D) and DHF, using a salsalate (SSA), an anti-inflammatory agent that improves glycemic control in T2D. The proposed placebo-controlled double-blind RCT in patients with T2D and DHF will test the hypothesis that modulation of inflammatory pathways by salsalate leads to improved left venricular end-diastolic filling pressures (detemined by echo-derived indices of LV diastolic function) and improved patient funtional capacity (determined by V02max). B. Proposal for a Clinical Research Skills Development Core (CRSDC) to train HF clinical investigators. There are three major objectives of the CRSDC: 1. Support two CRSDC Scholars/year to undergo training in clinical HF research by enrolling in a 2-year Masters of Science degree program. Scholars will gain clinical research skills through coursework, seminars, and one-on-one contact with a multidisciplinary group of faculty/mentors involved in clinical research. 2. Develop individualized mentored program in clinical HF research. This will include: a) completion of a mentored clinical HF research project; b) promote scholar career advancement through mentoring and guidance; c) prepare and submit a grant proposal; and d) evaluate scholars, mentors and CRSDC program. 3. Implement a HF-specific curriculum: a) weekly CV seminars; b) quarterly HF lecture series; c) yearly HF symposium; d) HF Visiting Professorship; and e) optional external rotations.