Implementation Research Strategies for Heart, Lung, and Blood Co-morbidities in People Living with HIV - Research Coordinating Center

HIV 感染者心、肺和血液合并症的实施研究策略 - 研究协调中心

基本信息

  • 批准号:
    10705070
  • 负责人:
  • 金额:
    $ 191.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-30 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Globally, there were an estimated 36.9 million people living with HIV in 2017. As a result of the increased availability of antiretroviral therapy, life expectancy for these patients has increased, resulting in an expansion and aging of the HIV-infected population. Data from both high- and low-resource countries have shown an escalating burden of heart, lung, blood, and sleep (HLBS) disorders among HIV patients. Care for this now aging cohort requires modifying service delivery models towards the prevention, diagnosis, treatment, and control of chronic HLBS disorders. The successful implementation of various solutions developed in response to the global HIV/AIDS pandemic can serve as the foundation to transform global healthcare delivery systems towards HLBS disorder care. The overarching goals of this Research Coordinating Center are: (1) provide scientific, organizational, statistical, quality control, capacity building and operational leadership for the Implementation Science projects to be funded by the companion RFA-HL-20-025 and (2) promote and teach Implementation Research strategies to advance collaborative dialogue across projects and ensure up-to-date conceptualization, specification and measurement of implementation strategies and outcomes. In support of these goals, we have assembled a highly experienced and multidisciplinary research team. Our team, with expertise in running multicenter trials, dissemination and implementation research, biostatistics and research design, HIV, HLBS disorders, capacity building, and data management, will pursue the following specific aims: 1. To oversee management, organizational, and communication activities across all research sites including working with NHLBI to prepare meeting agendas, develop the study website, provide administrative support for research projects, and organize face-to-face meetings. 2. To collaborate with all research sites in developing the scientific and operational details of their implementation science research protocols. These efforts will include: a. Assisting study sites in designing, testing, and maintaining password protected data entry and management systems and ensuring that such systems implement robust quality control features. b. Harmonizing (a) demographic, clinical, and questionnaire measurements across research sites and (b) the conceptualization and measurement of implementation strategies and implementation outcomes. c. In collaboration with research sites, to statistically analyze harmonized data and to assist in the analysis of site-specific data as reports, manuscripts, and abstracts are prepared. 3. To measure critical contextual Implementation Science factors in each research setting in order to enable conceptualization of the mechanism of effect and, by extension, enable formalized assessments of external validity. To oversee the development and implementation of training and capacity building activities.
项目摘要/摘要 2017年,全球估计有3690万艾滋病毒携带者。由于增加了 在获得抗逆转录病毒治疗的情况下,这些患者的预期寿命增加了,从而导致了延长 以及艾滋病毒感染人口的老龄化。来自高资源和低资源国家的数据显示, 艾滋病毒患者的心肺、血液和睡眠(HLBS)障碍负担不断增加。照顾这个现在正在老化的人 队列需要修改服务交付模式,以预防、诊断、治疗和控制 慢性HLBS疾病。成功实施各种解决方案,以应对全球 艾滋病毒/艾滋病大流行可以作为将全球医疗保健提供系统转变为HLBS的基础 失调症护理。该研究协调中心的总体目标是:(1)提供科学、 组织、统计、质量控制、能力建设和执行的业务领导 将由伙伴RFA-HL-20-025资助的科学项目和(2)促进和教授实施 研究战略,以促进跨项目的协作对话,并确保最新的概念化, 具体说明和衡量实施战略和成果。为了支持这些目标,我们有 组建了一支经验丰富的多学科研究团队。我们的团队,拥有跑步方面的专业知识 多中心试验、传播和实施研究、生物统计和研究设计、艾滋病毒、高密度脂蛋白 障碍、能力建设和数据管理将追求以下具体目标: 1.监督所有研究站点的管理、组织和沟通活动,包括 与NHLBI合作准备会议议程,开发学习网站,提供行政支持 用于研究项目,并组织面对面的会议。 2.与所有研究地点合作,制定其科学和操作细节 实施科学研究方案。这些努力将包括: A.协助学习网站设计、测试和维护受密码保护的数据输入和 管理系统,并确保这些系统实施强有力的质量控制特征。 B.协调(A)各研究地点的人口统计、临床和问卷测量,以及(B) 执行战略和执行成果的概念化和衡量。 C.与研究地点协作,对统一数据进行统计分析,并协助分析 准备了报告、手稿和摘要等现场具体数据。 3.衡量每个研究环境中的关键背景实施科学因素,以便实现 对效果机制进行概念化,进而使外部评估得以正规化 有效性。 监督培训和能力建设活动的发展和实施。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Victor G. Davila-Roman其他文献

NETWORK ANALYSIS OF EPISTATIC INTERACTIONS AMONG FOUR MYOCARDIAL FATTY ACID METABOLISM CANDIDATE GENES MODULATING HYPERTENSIVE HEART DISEASE
  • DOI:
    10.1016/s0735-1097(10)61227-2
  • 发表时间:
    2010-03-09
  • 期刊:
  • 影响因子:
  • 作者:
    Lisa de las Fuentes;Jyh M. Juang;Sharlee Climer;Victor G. Davila-Roman
  • 通讯作者:
    Victor G. Davila-Roman
PRENATAL ASPIRIN USE IS ASSOCIATED WITH REDUCED INCIDENCE OF POSTPARTUM HYPERTENSION AMONG WOMEN WITH PREECLAMPSIA
  • DOI:
    10.1016/s0735-1097(20)32468-2
  • 发表时间:
    2020-03-24
  • 期刊:
  • 影响因子:
  • 作者:
    Eleanor Christenson;Molly J. Stout;Dominique Williams;Amanda Verma;Douglas L. Mann;Victor G. Davila-Roman;Kathryn Lindley
  • 通讯作者:
    Kathryn Lindley
A DIET HIGH IN LONG CHAIN FATTY ACIDS WORSENS SYSTOLIC FUNCTION IN TYPE II DIABETIC PATIENTS, BUT A DIET RICH IN MEDIUM CHAIN FATTY ACIDS DOES NOT: A RANDOMIZED, DOUBLE-BLIND STUDY
  • DOI:
    10.1016/s0735-1097(13)60763-9
  • 发表时间:
    2013-03-12
  • 期刊:
  • 影响因子:
  • 作者:
    Sophia LaHusen-Bair;Andrew R. Coggan;Adil Bashir;Marsha Farmer;Robert O'Connor;Catherine Anderson-Spearie;Alan D. Waggoner;Pamela Woodard;Cylen Javidan;Babak Banan;Kitty Krupp;Victor G. Davila-Roman;Linda R. Peterson
  • 通讯作者:
    Linda R. Peterson
Postoperative myocardial wall stress in patients with chronic aortic insufficiency: Ross procedure versus St. Jude mechanical aortic valve prosthesis
  • DOI:
    10.1016/s0735-1097(02)81928-3
  • 发表时间:
    2002-03-06
  • 期刊:
  • 影响因子:
  • 作者:
    Pavlos Moustakidis;Brian P. Cupps;Hersh S. Maniar;Giridhar Vedala;Lisa De Las Fuentes;Thoralf M. Sundt;Nicholas T. Kouchoukos;Victor G. Davila-Roman;Michael K. Pasque
  • 通讯作者:
    Michael K. Pasque
Early postoperative complications detected by transesophageal echocardiography in cardiothoracic surgery patients
  • DOI:
    10.1016/0735-1097(90)92235-t
  • 发表时间:
    1990-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Victor G. Davila-Roman;Benico Barzilai;Mark Eaton;Thomas A. Wareing;Nicholas T. Kouchoukos
  • 通讯作者:
    Nicholas T. Kouchoukos

Victor G. Davila-Roman的其他文献

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{{ truncateString('Victor G. Davila-Roman', 18)}}的其他基金

SYNthetic Healthcare DAta Platform for Data SciEnce Training ("SYNAPSE")
用于数据科学培训的综合医疗保健数据平台(“SYNAPSE”)
  • 批准号:
    10717478
  • 财政年份:
    2023
  • 资助金额:
    $ 191.42万
  • 项目类别:
Enhancing Cardiovascular Health Equity in Mothers and Children Through Home Visiting
通过家访提高母亲和儿童的心血管健康公平性
  • 批准号:
    10618374
  • 财政年份:
    2022
  • 资助金额:
    $ 191.42万
  • 项目类别:
Washington University SummeR reseArch DIversity ProgrAm iN Cardiovascular Disease & HEmatology (RADIANCE)
华盛顿大学心血管疾病夏季研究多样性计划
  • 批准号:
    10619007
  • 财政年份:
    2022
  • 资助金额:
    $ 191.42万
  • 项目类别:
Enhancing Cardiovascular Health Equity in Mothers and Children Through Home Visiting
通过家访提高母亲和儿童的心血管健康公平性
  • 批准号:
    10426758
  • 财政年份:
    2022
  • 资助金额:
    $ 191.42万
  • 项目类别:
Research Training in Data Science for Health in Rwanda
卢旺达健康数据科学研究培训
  • 批准号:
    10490313
  • 财政年份:
    2021
  • 资助金额:
    $ 191.42万
  • 项目类别:
Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru
研究培训:秘鲁的慢性非传染性心血管疾病和合并症
  • 批准号:
    10483128
  • 财政年份:
    2021
  • 资助金额:
    $ 191.42万
  • 项目类别:
Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru
研究培训:秘鲁的慢性非传染性心血管疾病和合并症
  • 批准号:
    10308323
  • 财政年份:
    2021
  • 资助金额:
    $ 191.42万
  • 项目类别:
Research Training in Data Science for Health in Rwanda
卢旺达健康数据科学研究培训
  • 批准号:
    10675593
  • 财政年份:
    2021
  • 资助金额:
    $ 191.42万
  • 项目类别:
Research Training in Data Science for Health in Rwanda
卢旺达健康数据科学研究培训
  • 批准号:
    10320162
  • 财政年份:
    2021
  • 资助金额:
    $ 191.42万
  • 项目类别:
Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru
研究培训:秘鲁的慢性非传染性心血管疾病和合并症
  • 批准号:
    10680600
  • 财政年份:
    2021
  • 资助金额:
    $ 191.42万
  • 项目类别:

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