Implementation Research Strategies for Heart, Lung, and Blood Co-morbidities in People Living with HIV - Research Coordinating Center

HIV 感染者心、肺和血液合并症的实施研究策略 - 研究协调中心

• 批准号: 10260644
• 负责人: Victor G. Davila-Roman
• 金额: $ 199.02万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260644
• 关键词: AIDS/HIV problem; Aging; Bioinformatics; Biometry; Blood; Caring; Chronic; Clinical; Clinical Research; Collaborations; Communication; Companions; Country; Data; Data Analyses; Development; Diagnosis; Disease; Disease Management; Disease Progression; Dissemination and Implementation; Economic Policy; Ensure; Epidemic; Foundations; Funding; Funding Opportunities; Goals; HIV; Health system; Heart; Heart Diseases; Hematological Disease; Human Resources; Infrastructure; Institutes; Interdisciplinary Study; International; Intervention; Knowledge; Leadership; Life Expectancy; Lung; Lung diseases; Manuscripts; Measurement; Measures; Multicenter Studies; Multicenter Trials; National Heart, Lung, and Blood Institute; Patients; Population; Prevention; Protocols documentation; Public Health; Quality Control; Questionnaires; Recording of previous events; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Rice; Running; Service delivery model; Site; Sleep; Sleep Disorders; Structure; System; Testing; Training; Training Programs; Universities; Washington; antiretroviral therapy; cohort; comorbidity; data harmonization; data management; data quality; design; dissemination research; effective intervention; efficacious treatment; epidemiology study; experience; global health; health care delivery; health economics; implementation outcomes; implementation research; implementation science; implementation strategy; insight; low and middle-income countries; meetings; pandemic disease; response; scientific organization; service delivery; skill acquisition; web site

PROJECT SUMMARY/ABSTRACT Globally, there were an estimated 36.9 million people living with HIV in 2017. As a result of the increased availability of antiretroviral therapy, life expectancy for these patients has increased, resulting in an expansion and aging of the HIV-infected population. Data from both high- and low-resource countries have shown an escalating burden of heart, lung, blood, and sleep (HLBS) disorders among HIV patients. Care for this now aging cohort requires modifying service delivery models towards the prevention, diagnosis, treatment, and control of chronic HLBS disorders. The successful implementation of various solutions developed in response to the global HIV/AIDS pandemic can serve as the foundation to transform global healthcare delivery systems towards HLBS disorder care. The overarching goals of this Research Coordinating Center are: (1) provide scientific, organizational, statistical, quality control, capacity building and operational leadership for the Implementation Science projects to be funded by the companion RFA-HL-20-025 and (2) promote and teach Implementation Research strategies to advance collaborative dialogue across projects and ensure up-to-date conceptualization, specification and measurement of implementation strategies and outcomes. In support of these goals, we have assembled a highly experienced and multidisciplinary research team. Our team, with expertise in running multicenter trials, dissemination and implementation research, biostatistics and research design, HIV, HLBS disorders, capacity building, and data management, will pursue the following specific aims: 1. To oversee management, organizational, and communication activities across all research sites including working with NHLBI to prepare meeting agendas, develop the study website, provide administrative support for research projects, and organize face-to-face meetings. 2. To collaborate with all research sites in developing the scientific and operational details of their implementation science research protocols. These efforts will include: a. Assisting study sites in designing, testing, and maintaining password protected data entry and management systems and ensuring that such systems implement robust quality control features. b. Harmonizing (a) demographic, clinical, and questionnaire measurements across research sites and (b) the conceptualization and measurement of implementation strategies and implementation outcomes. c. In collaboration with research sites, to statistically analyze harmonized data and to assist in the analysis of site-specific data as reports, manuscripts, and abstracts are prepared. 3. To measure critical contextual Implementation Science factors in each research setting in order to enable conceptualization of the mechanism of effect and, by extension, enable formalized assessments of external validity. To oversee the development and implementation of training and capacity building activities.

项目概要/摘要 2017 年，全球估计有 3690 万人感染艾滋病毒。 由于抗逆转录病毒治疗的可用性，这些患者的预期寿命有所增加，从而导致 以及艾滋病毒感染者的老龄化。来自资源丰富国家和资源匮乏国家的数据均显示 HIV 患者心、肺、血液和睡眠 (HLBS) 疾病的负担不断增加。照顾这个现在老化的 队列需要修改服务提供模式，以预防、诊断、治疗和控制 慢性 HLBS 疾病。成功实施了针对全球需求而开发的各种解决方案 HIV/艾滋病大流行可以作为将全球医疗保健服务系统转变为 HLBS 的基础 紊乱护理。该研究协调中心的总体目标是：（1）提供科学、 实施的组织、统计、质量控制、能力建设和业务领导 由配套 RFA-HL-20-025 资助的科学项目和 (2) 促进和教授实施 研究策略以促进跨项目的协作对话并确保最新的概念化， 实施策略和结果的规范和衡量。为了支持这些目标，我们 组建了一支经验丰富的多学科研究团队。我们的团队拥有跑步方面的专业知识 多中心试验、传播和实施研究、生物统计学和研究设计、HIV、HLBS 疾病、能力建设和数据管理，将追求以下具体目标： 1. 监督所有研究中心的管理、组织和沟通活动，包括 与 NHLBI 合作准备会议议程、开发研究网站、提供行政支持 研究项目，并组织面对面的会议。 2. 与所有研究中心合作，制定其研究的科学和操作细节 实施科学研究协议。这些努力将包括： 一个。协助研究中心设计、测试和维护受密码保护的数据输入和 管理系统并确保此类系统实施强大的质量控制功能。 b.协调 (a) 跨研究地点的人口统计、临床和问卷测量，以及 (b) 实施战略和实施结果的概念化和衡量。 c.与研究机构合作，对统一数据进行统计分析并协助分析 准备报告、手稿和摘要等特定地点的数据。 3. 衡量每个研究环境中关键的背景实施科学因素，以便能够 影响机制的概念化，并推而广之，使外部的正式评估成为可能 有效性。 监督培训和能力建设活动的制定和实施。