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Men's INTernet Study III (MINTS-III) for HIV Prevention

预防艾滋病毒的男性互联网研究 III (MINTS-III)

基本信息

批准号：
8444676
负责人：
B R Simon Rosser
金额：
$ 57.03万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-22 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8444676
关键词：
AIDS prevention Affect Anus Area Awareness Behavioral Build-it Cognitive Computers Control Groups Data Deception Effectiveness Effectiveness of Interventions Ensure Ethnic Origin Feedback Funding Game Theory HIV HIV risk Health Health Services Individual Information Technology Internet Intervention Interview Knowledge Latino Length Measurement Measures Mediation Methods Needs Assessment Noise Outcome Participant Population Positioning Attribute Prevention Research Prevention approach Preventive Intervention Process Productivity Progress Reports Public Health Publications Race Recruitment Activity Reporting Research Respondent Risk Risk Assessment Risk Behaviors Risk Reduction Science Self Efficacy Self-control as a personality trait Sexual Health Social Desirability Social support Stress Surveys Tail Targeted Research Technology Telephone Testing Time Treatment Efficacy United States National Institutes of Health Validity and Reliability Variant arm base conditioning condoms design dosage effective intervention experience follow-up group intervention high risk high risk behavior high risk men high risk sexual behavior improved innovation instrument male men men who have sex with men novel strategies post intervention protective efficacy public health relevance response service intervention sex sex risk skills social theories usability user centered design

项目摘要

DESCRIPTION (provided by applicant): MINTS-III is a competing continuation application resubmission in response to PA-07-295. It builds upon MINTS-I, one of the first survey studies of the Internet and HIV risk among MSM; and MINTS-II, which developed and tested Sexpulse, an online, HIV prevention intervention for Men who use the Internet to seek Sex with Men (MISM). MINTS-II is the first online RCT of MISM to report acceptable retention over 12 months and short-term efficacy. At the 3-month follow-up, the intervention group reported a significantly greater (20%) reduction in risk behavior than the null control. We also observed a significant reduction in reported risk behavior in the control group, which we hypothesize is the product of panel conditioning. MINTS-III is the logical next step in this promising area of research. Our first aim is to increase the long-term HIV prevention effectiveness of the intervention by strengthening the dosage of Sexpulse. A substantial user-centered design iteration of the intervention will incorporate personalized, tailored feedback on individual risk behavior; integrate research surveys into the intervention; and add follow-up boosters all aimed at increasing the long-term behavioral effectiveness. In Aim 2, we propose two sub-studies to examine the reliability and validity of online measures of sexual risk behavior. Aim 3 tests the long-term risk reduction efficacy of the strengthened intervention, Sexpulse 1.1, and boosters, in an RCT of 1000 high-risk MISM. This RCT design has been enhanced by three levels of recruitment so that in Aim 4, we can study threats to risk measurement, especially panel conditioning. Our final aim tests the long-term protective efficacy of Sexpulse 1.1 (including online boosters) in an RCT on 500 no/lower risk MISM. Upon successful completion of these aims, Sexpulse 1.1 should be a strong and demonstrated-effective intervention that can be strategically positioned for dissemination.

描述（由申请人提供）：MINTS-III 是根据 PA-07-295 重新提交的竞争性延续申请。它建立在 MINTS-I 的基础上，MINTS-I 是第一个针对 MSM 中互联网和艾滋病毒风险的调查研究之一； MINTS-II 开发并测试了 Sexpulse，这是一种针对使用互联网寻求与男性发生性行为的男性 (MISM) 的在线艾滋病毒预防干预措施。 MINTS-II 是第一个 MISM 在线随机对照试验，报告 12 个月内可接受的保留率和短期疗效。在 3 个月的随访中，干预组的危险行为比零对照组显着减少了 20%。我们还观察到对照组报告的风险行为显着减少，我们假设这是面板调节的产物。 MINTS-III 是这一前景广阔的研究领域中合乎逻辑的下一步。我们的首要目标是通过加强 Sexpulse 的剂量来提高干预措施的长期艾滋病毒预防效果。以用户为中心的干预设计迭代将纳入针对个人风险行为的个性化、量身定制的反馈；将研究调查纳入干预措施；并添加后续助推器，所有这些都旨在提高长期行为有效性。在目标 2 中，我们提出了两项子研究来检验性风险行为在线测量的可靠性和有效性。目标 3 在 1000 名高风险 MISM 的随机对照试验中测试强化干预措施 Sexpulse 1.1 和增强剂的长期风险降低功效。该 RCT 设计通过三个级别的招募得到了增强，因此在目标 4 中，我们可以研究对风险测量的威胁，尤其是小组调节。我们的最终目标是在 500 个无/低风险 MISM 的随机对照试验中测试 Sexpulse 1.1（包括在线增强剂）的长期保护功效。成功完成这些目标后，Sexpulse 1.1 应该成为一项强有力且行之有效的干预措施，可以战略性地进行传播。