Men's INTernet Study III (MINTS-III) for HIV Prevention

预防艾滋病毒的男性互联网研究 III (MINTS-III)

基本信息

批准号：
8444676
负责人：
B R Simon Rosser
金额：
$ 57.03万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-22 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8444676
关键词：
AIDS prevention Affect Anus Area Awareness Behavioral Build-it Cognitive Computers Control Groups Data Deception Effectiveness Effectiveness of Interventions Ensure Ethnic Origin Feedback Funding Game Theory HIV HIV risk Health Health Services Individual Information Technology Internet Intervention Interview Knowledge Latino Length Measurement Measures Mediation Methods Needs Assessment Noise Outcome Participant Population Positioning Attribute Prevention Research Prevention approach Preventive Intervention Process Productivity Progress Reports Public Health Publications Race Recruitment Activity Reporting Research Respondent Risk Risk Assessment Risk Behaviors Risk Reduction Science Self Efficacy Self-control as a personality trait Sexual Health Social Desirability Social support Stress Surveys Tail Targeted Research Technology Telephone Testing Time Treatment Efficacy United States National Institutes of Health Validity and Reliability Variant arm base conditioning condoms design dosage effective intervention experience follow-up group intervention high risk high risk behavior high risk men high risk sexual behavior improved innovation instrument male men men who have sex with men novel strategies post intervention protective efficacy public health relevance response service intervention sex sex risk skills social theories usability user centered design

项目摘要

DESCRIPTION (provided by applicant): MINTS-III is a competing continuation application resubmission in response to PA-07-295. It builds upon MINTS-I, one of the first survey studies of the Internet and HIV risk among MSM; and MINTS-II, which developed and tested Sexpulse, an online, HIV prevention intervention for Men who use the Internet to seek Sex with Men (MISM). MINTS-II is the first online RCT of MISM to report acceptable retention over 12 months and short-term efficacy. At the 3-month follow-up, the intervention group reported a significantly greater (20%) reduction in risk behavior than the null control. We also observed a significant reduction in reported risk behavior in the control group, which we hypothesize is the product of panel conditioning. MINTS-III is the logical next step in this promising area of research. Our first aim is to increase the long-term HIV prevention effectiveness of the intervention by strengthening the dosage of Sexpulse. A substantial user-centered design iteration of the intervention will incorporate personalized, tailored feedback on individual risk behavior; integrate research surveys into the intervention; and add follow-up boosters all aimed at increasing the long-term behavioral effectiveness. In Aim 2, we propose two sub-studies to examine the reliability and validity of online measures of sexual risk behavior. Aim 3 tests the long-term risk reduction efficacy of the strengthened intervention, Sexpulse 1.1, and boosters, in an RCT of 1000 high-risk MISM. This RCT design has been enhanced by three levels of recruitment so that in Aim 4, we can study threats to risk measurement, especially panel conditioning. Our final aim tests the long-term protective efficacy of Sexpulse 1.1 (including online boosters) in an RCT on 500 no/lower risk MISM. Upon successful completion of these aims, Sexpulse 1.1 should be a strong and demonstrated-effective intervention that can be strategically positioned for dissemination.

描述（由申请人提供）：Mints-III是响应PA-07-295的竞争延续申请。它建立在MINTS-I的基础上，这是MSM中互联网和HIV风险的首次调查研究之一；和Mints-II，开发和测试了Sexpulse，这是一种在线预防艾滋病毒的干预措施，适用于使用互联网寻求与男性发生性关系的男性。 MINTS-II是第一个在12个月内报告可接受的保留率和短期疗效的在线RCT。在3个月的随访中，干预组报告的风险行为降低（20％）明显高于无效控制。我们还观察到对照组报告的风险行为大幅降低，我们认为这是面板调节的产物。 Mints-III是这一有希望的研究领域的逻辑下一步。我们的第一个目的是通过加强性腔的剂量来提高干预的长期预防效果。以用户为中心的干预措施的实质性设计迭代将结合个人风险行为的个性化，量身定制的反馈；将研究调查整合到干预措施中；并增加后续助推器，旨在提高长期行为效率。在AIM 2中，我们提出了两个子阶级，以检查在线性风险行为的在线度量的可靠性和有效性。 AIM 3测试了加强干预，性脉冲1.1和助推器的长期风险降低功效，其RCT为1000个高风险不利。这种RCT设计已通过三个级别的招聘增强，因此在AIM 4中，我们可以研究风险测量的威胁，尤其是面板条件。我们的最终目标测试了Sexpulse 1.1（包括在线助推器）在500 no/sownly风险中的RCT中的长期保护功效。成功完成这些目标后，Sexpulse 1.1应该是一种强大而有效的干预措施，可以在战略上定位进行传播。