Restore: Improving Sexual Outcomes of Gay and Bisexual Prostate Cancer Survivors

恢复:改善同性恋和双性恋前列腺癌幸存者的性结果

基本信息

  • 批准号:
    10206046
  • 负责人:
  • 金额:
    $ 58.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Abstract: This application, in response to PA-15-261, “Research leading to interventions to ameliorate health disparities of sexual and gender minorities”, advances research in three areas. First, prostate cancer (PCa) is the second most common cancer among gay, bisexual, and other men who have sex with men (GBM), with documented disparities, yet it is severely under-researched. Because gay sex differs from vaginal sex, physiologically; the results from 614 studies focused on heterosexual men likely do not generalize to GBM with PCa. There have been no rehabilitation studies specific to GBM survivors of PCa, so clinicians have no relevant studies to inform best practice with their GBM patients. Second, most PCa studies have tested one or rehabilitation components. We will conduct the first treatment study of a state of clinical practice comprehensive rehabilitation program on GBM's quality of life, including on both urinary and sexual function and bother measures. Third, almost all PCa studies have focused on men recently treated for PCa. We will study both GBM recently treated (last 2 years) and GBM post-treatment (2+ years), using a stratified design. This study builds on our findings in Restore, an R21 which was only the second study of GBM with PCa to be funded by NCI, and the first to reach publication. We conducted N=41 in-depth qualitative interviews with good saturation, and the largest quantitative study of GBM with PCa to date (N=193), the first needs assessment of GBM with PCa, and the first study of same sex partners and care-givers of GBM. Participants described radical prostatectomy as leaving them “humiliated,” “maimed”, “less than other gay men,” and “severely depressed.” Most (88%) reported ongoing sexual challenges contributing to decreased quality of life, poorer mental health, identity challenges and deteriorated primary relationships. Only three of the eight (38%) outcomes commonly experienced by most GBM were discussed as part of treatment. There was no evidence of any standard of professional rehabilitation; indeed, most GBM just treated themselves. The long-term objective of this research is to improve the health of GBM survivors of PCa and to provide an evidence base for rehabilitation. In Aim I, we will develop an online rehabilitation program tailored for GBM that addresses both the sexual and urinary effects of PCa treatment. In Aim II, we will conduct a comparative recruitment study to identify best methods to recruit 450 GBM with PCa. In Aim III, we will evaluate the effects of the tailored rehabilitation program on sexual and urinary outcomes. We will conduct a 24 month, randomized controlled trial of structured rehabilitation versus routine care. This RCT will identify whether a structured rehabilitation program is effective in addressing the major sexual and urinary problems caused by PCa treatment. As the first treatment study to focus on GBM with PCa (and also on oral and anal sex), it addresses a long-standing health disparity. The study has high potential to transform rehabilitation for GBM with PCa, provide a critical evidence base for clinicians, and inform rehabilitation outcomes for all PCa survivors.
摘要:本申请应PA-15-261“研究导致改善健康的干预措施

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Health Disparities of Sexual Minority Patients Following Prostate Cancer Treatment: Results From the Restore-2 Study.
  • DOI:
    10.3389/fonc.2022.812117
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Rosser BRS;Polter EJ;Talley KMC;Wheldon CW;Haggart R;Wright M;West W;Mitteldorf D;Ross MW;Konety BR;Kohli N
  • 通讯作者:
    Kohli N
Recruiting an underserved, difficult to reach population into a cancer trial: Strategies from the Restore-2 Rehabilitation Trial for gay and bisexual prostate cancer patients.
  • DOI:
    10.1177/17407745221077678
  • 发表时间:
    2022-06
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Rosser, B. R. Simon;Wright, Morgan;Hoefer, Chris J.;Polter, Elizabeth J.;Kohli, Nidhi;Wheldon, Christopher W.;Haggart, Ryan;Mc Talley, Kristine;Mitteldorf, Darryl;Kilian, Gunna;Konety, Badrinath R.;Ross, Michael W.;West, William
  • 通讯作者:
    West, William
The Challenge of Coming Out to Providers by Gay and Bisexual Men With Prostate Cancer: Qualitative Results from the Restore Study.
  • DOI:
    10.1080/19317611.2021.1924335
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    2
  • 作者:
    West, William;Torres, Maria Beatriz;Mitteldorf, Darryl;Capistrant, Benjamin D.;Konety, Badrinath R.;Polter, Elizabeth;Rosser, B. R. Simon
  • 通讯作者:
    Rosser, B. R. Simon
Creation and Psychometric Validation of the Sexual Minorities and Prostate Cancer Scale (SMACS) in Sexual Minority Patients-The Restore-2 Study.
  • DOI:
    10.1016/j.jsxm.2021.12.012
  • 发表时间:
    2022-03
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Polter EJ;Kohli N;Rosser BRS;Talley KMC;Wheldon CW;Hoefer CJ;Wright M;Haggart R;Mitteldorf D;Kilian G;Konety BR;Ross MW;West W
  • 通讯作者:
    West W
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B R Simon Rosser其他文献

B R Simon Rosser的其他文献

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{{ truncateString('B R Simon Rosser', 18)}}的其他基金

Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies
测试招募性少数癌症患者进行癌症研究的有效方法
  • 批准号:
    10771387
  • 财政年份:
    2022
  • 资助金额:
    $ 58.01万
  • 项目类别:
Training the Long-Term Services and Supports Dementia Care Workforce in Provision of Care to Sexual and Gender Minority Residents
培训长期服务和支持痴呆症护理人员,为性少数群体居民提供护理
  • 批准号:
    10523826
  • 财政年份:
    2022
  • 资助金额:
    $ 58.01万
  • 项目类别:
Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies
测试招募性少数癌症患者进行癌症研究的有效方法
  • 批准号:
    10515913
  • 财政年份:
    2022
  • 资助金额:
    $ 58.01万
  • 项目类别:
Training the Long-Term Services and Supports Dementia Care Workforce in Provision of Care to Sexual and Gender Minority Residents
培训长期服务和支持痴呆症护理人员,为性少数群体居民提供护理
  • 批准号:
    10703475
  • 财政年份:
    2022
  • 资助金额:
    $ 58.01万
  • 项目类别:
Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies
测试招募性少数癌症患者进行癌症研究的有效方法
  • 批准号:
    10683296
  • 财政年份:
    2022
  • 资助金额:
    $ 58.01万
  • 项目类别:
Restore: Improving Sexual Outcomes of Gay and Bisexual Prostate Cancer Survivors
恢复:改善同性恋和双性恋前列腺癌幸存者的性结果
  • 批准号:
    9980806
  • 财政年份:
    2017
  • 资助金额:
    $ 58.01万
  • 项目类别:
Restore: Improving Sexual Outcomes of Gay and Bisexual Prostate Cancer Survivors
恢复:改善同性恋和双性恋前列腺癌幸存者的性结果
  • 批准号:
    9528534
  • 财政年份:
    2017
  • 资助金额:
    $ 58.01万
  • 项目类别:
Understanding the Effects of Prostate Cancer on Gay and Bisexual Men
了解前列腺癌对男同性恋和双性恋男性的影响
  • 批准号:
    8927565
  • 财政年份:
    2014
  • 资助金额:
    $ 58.01万
  • 项目类别:
Understanding the Effects of Prostate Cancer on Gay and Bisexual Men
了解前列腺癌对男同性恋和双性恋男性的影响
  • 批准号:
    8767750
  • 财政年份:
    2014
  • 资助金额:
    $ 58.01万
  • 项目类别:
Men's INTernet Study III (MINTS-III) for HIV Prevention
预防艾滋病毒的男性互联网研究 III (MINTS-III)
  • 批准号:
    8444676
  • 财政年份:
    2010
  • 资助金额:
    $ 58.01万
  • 项目类别:

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机构外的生活:1900 - 1960 年心理健康善后护理的历史
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