Center for Cancer Biology

项目摘要 COBRE的主要目标是建立在基础科学和转化癌症的临界质量基础上 研究人员在癌症生物学研究中心的第一阶段资助期间开发的。二期 将专注于与人类患者直接相关的癌症研究。因此，我们的五个项目中有四个 领导者是拥有基础、转化和临床癌症研究专业知识的医生科学家。它将 将我们的实验室发现转化为人体临床试验的目标。将重点放在头部， 颈部鳞状细胞癌和免疫系统在治疗患者的重要性， 疾病持续的COBRE资助将使我们能够在这一领域建立一个核心的研究人员 谁将有竞争力的外部同行评审计划项目赠款支持，帮助我们达到 可持续性超出COBRE资金。第二个主题是儿童癌症， 第二阶段融资。对研究核心设施的持续支持将有助于我们的研究人员获得关键的 提交竞争性赠款申请的初步数据。我们将培养多层次的学生， 帮助建立区域癌症研究工作队伍。我们希望博士和临床科学家谁在我们的培训 实验室建立成功的职业生涯作为癌症研究人员。为了实现这些目标，我们 建立了以下几个具体目标：1）支持5个项目负责人的研究，使他们能够 建立有竞争力的，资助的研究项目。支持将包括指导，参与机会， 培训学生，获得进一步的技能，在实验室管理，拨款的写作和审查，并出版。2)到 建立有效的咨询委员会，指导中心的进一步发展。这将包括内部 咨询委员会和外部咨询委员会。每个委员会都将由 并建立了具有与中心目标相关的专业知识的调查人员。3)支持两个核心 实验室将提供基本服务，以支持项目负责人和其他研究人员。的 2个核心实验室为分子病理学（核心B）和流式细胞术（核心C）。两个核心都是 它是由第一阶段的资金启动的，将被所有第二阶段的项目领导人大量使用。4)提供试点项目 供资的目标是支持与总主题有关的项目，这些项目有可能导致进一步的 外部资金，从而提高整体中心。总的来说，我们希望在以下领域建立良好的基础： 头颈部癌症和儿童癌症，因此在计划项目类型的资金方面具有竞争力（例如， 这将给我们的中心带来长期的稳定。在这方面，我们期望进一步发展我们的专业知识， 这使得基本的发现能够转化为人类癌症患者的临床试验。

PROJECT SUMMARY The primary goal of the COBRE is to build upon the critical mass of basic science and translational cancer researchers that has been developed during Phase I funding of the Cancer Biology Research Center. Phase II will focus on cancer research with direct translational relevance to human patients. Thus four of our five project leaders are physician scientists with expertise spanning basic, translational, and clinical cancer research. It will be a goal to translate our laboratory findings into human clinical trials. There will be an emphasis on head and neck squamous cell carcinoma and the importance of the immune system in treatment of patients with this disease. Continued COBRE funding will allow us to establish a core of established researchers in this area who will be competitive for external peer-reviewed program project grant support, helping us to reach sustainability beyond COBRE funding. A second theme of childhood cancers will be developed over the period of Phase II funding. Continued support of research core facilities will aid our investigators in obtaining critical preliminary data for the submission of competitive grant applications. We will train students at multiple levels to help build the regional cancer research work force. We expect PhD and clinician scientists who train in our laboratories to establish successful careers as cancer researchers. To accomplish these goals we have established several specific aims as follows: 1) to support the research of 5 Project Leaders allowing them to establish competitive, funded research programs. Support will include mentoring, opportunities to participate in training of students, gaining further skills in lab management, grant writing and reviewing, and publishing. 2) to establish effective advisory committees to guide further development of the center. This will include an Internal Advisory Committee and an External Advisory Committee. Each committee will be made up of highly regarded and established investigators with expertise relevant to the goals of the center. 3) to support two Core Laboratories that will provide essential services in support of the Project Leaders and other investigators. The 2 Core Laboratories will be Molecular Pathology (Core B) and Flow Cytometry (Core C). Both cores were initiated with Phase I funding and will be heavily used by all Phase II project leaders. 4) Provide pilot project funding with the goal of supporting projects related to the overall theme that have the potential to lead to further external funding, thus enhancing the overall center. Overall, we expect to become well established in the areas of head and neck cancer and childhood cancers, thus being competitive for program project type funding (e.g. P01) that will bring long term stability to our center. In this pursuit, we expect to further develop our expertise that allows basic discoveries to be translated into clinical trials in human cancer patients.