Medical Genetics Training Program

描述（由申请人提供）：人类遗传学在过去几十年中已经成为基础和生物医学研究的中心焦点，并且是一个真正的综合领域。对人类疾病分子基础的研究有望对我们对疾病发病机制的基本理解产生重要的见解，并在治疗和临床应用方面具有巨大的希望。本申请要求在哥伦比亚大学医学中心建立一个医学遗传学培训项目，每年为三名博士后培训生提供资助，该项目是一个全校范围的人类遗传学培训项目。培训的重点是儿童和成人的孟德尔和复杂疾病的临床、分子和遗传方面。医学遗传学培训计划的主要优势在于培训师资的卓越质量和多样性，这为学员提供了在国际公认的实验室和临床环境中进行博士后研究的机会。来自不同部门的23名教师参加了这个培训项目，他们作为培训师和导师有着丰富的经验和出色的业绩记录。我们的使命是推进人类遗传学的基础科学，并通过转化研究将这些进步纳入临床实践。该培训基金的目标与nigms支持的医学遗传学博士后培训计划直接一致，旨在促进人类遗传学基础和临床方面的研究事业。我们培训计划的临床、教学和研究部分旨在为医学学术生涯做好准备。医学遗传学培训项目将为博士后提供全面的培训体验，为他们未来的学术生涯提供帮助，并为中国中医药大学多个不同项目的人类遗传学发展创造一个论坛。

DESCRIPTION (provided by applicant): Human Genetics has become a central focus of basic and biomedical research over the past decades, and is truly an integrative field. The study of the molecular basis of human disease promises to yield significant insights into our basic understanding of disease pathogenesis, and holds enormous promise in terms of therapeutic and clinical applications. This application requests funds to establish a Medical Genetics Training Program at Columbia University Medical Center to support three postdoctoral trainees per year, in a University-wide training program on the topic of Human Genetics. Training focuses on the clinical, molecular and genetic aspects of both Mendelian and complex diseases in children and adults. The major strength of the Medical Genetics Training Program is the outstanding quality and diversity of the training faculty, which provides trainees with the opportunity to perform postdoctoral research in laboratories and clinical settings that are internationally recognized. Twenty three faculty members representing many different Departments are included in this training program and have extensive experience and outstanding track records as trainers and mentors. Our mission is to advance the science underlying human genetics, and incorporate these advances into clinical practice through translational research. The goals of this Training Grant are directly aligned with NIGMS-supported postdoctoral training programs in medical genetics, which are designed to foster research careers in both basic and clinical aspects of human genetics. The clinical, didactic and research components of our Training Program are intended to prepare physician- scientists for a career in academic medicine. The Medical Genetics Training Program will provide an outstanding well-rounded training experience for postdoctoral trainees that will allow them to pursue a future academic career, and create a forum for the advancement of human genetics from many different programs at CUMC.