Center for Biomedical Research Excellence in the Molecular Basis of Human Disease

人类疾病分子基础卓越生物医学研究中心

• 批准号: 8489308
• 负责人: Louis B. Hersh
• 金额: $ 207.38万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8489308
• 关键词: 5' -AMP-activated protein kinase; Appointment; Area; Award; Binding; Biochemistry; Biophysics; CSNK2A1 gene; Cells; Centers of Research Excellence; Chemistry; Collaborations; Complement; Core Facility; Data; Development; Diabetes Mellitus; Disease; Ensure; Equipment; Extramural Activities; Faculty; Family; Fatty Acids; Fee-for-Service Plans; Fluorescence; Funding; Genotype; Goals; Grant; Housing; Image; Individual; Investments; Kentucky; Life; Longevity; Malignant Neoplasms; Mass Spectrum Analysis; Medicine; Mentors; Microscopy; Molecular; Molecular Medicine; Mus; Natural Product Drug; Neurodegenerative Disorders; Neuropilins; Nursing Faculty; Organic Synthesis; Paper; Patients; Peptides; Phase; Phosphopeptides; Polymers; Positioning Attribute; Postdoctoral Fellow; Probability; Program Development; Program Research Project Grants; Proteins; Proteomics; Publications; Publishing; Recruitment Activity; Regulation; Research; Research Personnel; Research Project Grants; Research Training; Resources; Roentgen Rays; Role; Rosa; Sampling; Science; Scientist; Security; Services; Signal Transduction; Source; Spottings; Staining method; Stains; Surveys; T-Lymphocyte; Techniques; Technology; Translating; Two-Dimensional Gel Electrophoresis; Ultracentrifugation; United States National Institutes of Health; Universities; Wages; Work; analog; base; career; college; design; graduate student; human disease; improved; instrumentation; interest; large scale production; medical schools; meetings; member; mouse model; nervous system disorder; novel; programs; success

This proposal builds upon the accomplishments made during the previous funding period and requests continuing support of COBRE, the Center of Biomedical Research Excellence in the Molecular Basis of Human Disease. During the four year period this COBRE grant has been active, 22 junior faculty from 9 different departments were mentored of which 8 received NIH R01 funding and an additional 4 received Other forms of extramural funding. Participating in the activities of the Center has been an additional 11 faculty, 11 postodctorals/research associates and 9 graduate students. The members of the Center published more than 175 research papers, and made 38 presentations at scientific meetings. The Department of Molecular and Cellular Biochemistry, in which the COBRE is housed, rose from 28th to 12th in NIH rankings in terms of Public Medical Schools, and 26th in terms of all Medical Schools during the tenure of the COBRE. This was accomplished by an increase in $5,148,302 of NIH grant dollars excluding the COBRE funds. The Center for Molecular Medicine was formed in 2007 as a direct consequence of the accomplishments made during the first phase of the COBRE (Aug 2004- July 2009). In the second phase of this COBRE we propose to establish a nationally and internationally recognized research center that will continue to compete effectively for extramural research funding. To accomplish this we propose i) to expand our critical mass of investigators including the mentoring of an additional 5 promising junior investigators who are studying the molecular basis of human disease. This will include a targeted new recruit to the University. We will enhance the opportunity to translate their research to patients by facilitating interactions with clinical faculty. We will continue with the major focus in cancer, diabetes, and neurological diseases, ii) We will expand and continue to develop our core facilities in Proteomics, Chemistry, Microscopy, Protein characterization, and Mouse Genotyping. iii) We will continue to support pilot research projects. This has been a highly effective way to enhance the research of a rather significant number of junior faculty; iv) facilitate the development of a sustainable center through the submission of program project grants and multi-PI grants. We will provide staff resource and pilot funding to enhance these activities.

该提议建立在上一期资金期间所取得的成就，并要求对人类疾病分子基础生物医学研究中心Cobre继续支持。在四年期间，这笔鞋带赠款一直活跃，来自9个不同部门的22名初级教职员工得到了指导，其中8个获得了NIH R01资金，另外4个获得了其他形式的壁外资金。参加该中心的活动已有11位教职员工，11名后院/研究助理和9名研究生。该中心成员发表了175篇研究论文，并在科学会议上进行了38次演讲。毛皮所容纳的分子和细胞生物化学系在公立医学院的NIH排名中从28位上升到第12位，而在毛cre任职期间，所有医学院就第26位。这是通过不包括柯布尔资金（Cobre Funds）的NIH赠款$ 5,148,302的增加而实现的。分子医学中心成立于2007年，是毛cre第一阶段成就的直接结果（2004年8月至2009年7月）。 在此鞋底的第二阶段，我们建议建立一个在国内和国际认可的研究中心，该研究中心将继续有效地争夺校外研究资金。为了实现这一目标，我们建议i）扩大我们的关键研究人员的批量，包括对正在研究人类疾病分子基础的另外5位有前途的初级研究人员进行指导。这将包括有针对性的新兵到大学。我们将通过促进与临床教师的互动来增强将他们的研究转化为患者的机会。我们将继续关注癌症，糖尿病和神经系统疾病的主要重点，ii）我们将扩展并继续开发蛋白质组学，化学，显微镜，蛋白质表征和小鼠基因分型领域的核心设施。 iii）我们将继续支持试点研究项目。这是增强大量初级教师研究的一种非常有效的方法。 iv）通过提交计划项目赠款和多PI赠款来促进可持续中心的发展。我们将提供员工资源和试点资金来增强这些活动。

项目成果

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.

• DOI: 10.1016/j.jsb.2015.06.003
• 发表时间: 2015-08
• 期刊: Journal of structural biology
• 影响因子: 3
• 作者: Korotkova N;Piton J;Wagner JM;Boy-Röttger S;Japaridze A;Evans TJ;Cole ST;Pojer F;Korotkov KV
• 通讯作者: Korotkov KV

Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats.

• DOI: 10.3233/jad-160047
• 发表时间: 2016-05-05
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Verma N;Ly H;Liu M;Chen J;Zhu H;Chow M;Hersh LB;Despa F
• 通讯作者: Despa F

Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.

• DOI: 10.1371/journal.pone.0287086
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7

Application of the 4D fingerprint method with a robust scoring function for scaffold-hopping and drug repurposing strategies.

• DOI: 10.1021/ci5003872
• 发表时间: 2014-10-27
• 期刊: Journal of chemical information and modeling
• 影响因子: 5.6
• 作者: Hamza A;Wagner JM;Wei NN;Kwiatkowski S;Zhan CG;Watt DS;Korotkov KV
• 通讯作者: Korotkov KV

Novel mycosin protease MycP₁ inhibitors identified by virtual screening and 4D fingerprints.

• DOI: 10.1021/ci500025r
• 发表时间: 2014-04-28
• 期刊: Journal of chemical information and modeling
• 影响因子: 5.6
• 作者: Hamza A;Wagner JM;Evans TJ;Frasinyuk MS;Kwiatkowski S;Zhan CG;Watt DS;Korotkov KV
• 通讯作者: Korotkov KV