2013 Malaria Gordon Research Conference and Gordon Research Seminar

描述（由申请人提供）：2013年疟疾戈登研究会议（GRC）及其第一次相关的戈登研究研讨会（GRS）将集中在“疟疾的分子和细胞生物学”。这些会议将汇集来自不同学科的国际领先科学家，包括生物化学，药物化学，疫苗研究，分子遗传学，结构，细胞生物学和系统生物学，重点关注疟疾的最新进展。会议将强调疟疾寄生虫的基本生物学、免疫学、宿主-寄生虫-媒介相互作用和致病机制的分子和细胞方面。该论坛将提供一个令人振奋的论坛，讨论关于疟疾的前沿基础和应用研究，重点是有助于疫苗和药物开发的计划。第一届疟疾问题全球研究理事会于1997年9月举行，现已成为一个每两年举行一次的系列会议，在侧重于基础研究的会议和侧重于更多领域和临床方面的会议之间交替举行。2013年会议将侧重于前者：即强调对宿主-寄生虫-病媒相互作用的基础研究以及围绕开发新干预措施的概念。疟疾GRC在前几年非常受欢迎，是戈登会议中出席率最高的会议之一，通常超额认购。我们还预计，首次疟疾戈登研究研讨会的召开将促进年轻疟疾研究人员积极参与防治这一疾病的全球协作努力。2013年疟疾GRC的时间将与涉及约10，000名非洲婴儿和儿童的疟疾疫苗第一阶段3期临床试验的先进数据的可用性相吻合。介绍这些成果将是会议的一个主要重点。与此相反，在东南亚开始出现寄生虫对最新抗疟疾药物具有耐药性的报告，疟疾GRC的时间也将非常适合传播和讨论关于这一关键主题的最新发现。迫切需要了解这种耐药性的新机制，以及对新干预措施的持续需求，并更深入地了解宿主-寄生虫-病媒相互作用。2013年疟疾GRC及其第一个相关的GRS是重要的机会，为建立和新兴的疟疾研究领导者收集和解决这些问题的主持下，一系列会议，有一个声誉的最新未发表的数据介绍，然后进行积极和广泛的讨论。

DESCRIPTION (provided by applicant): The 2013 Malaria Gordon Research Conference (GRC) and its first associated Gordon Research Seminar (GRS) will focus on "Molecular and Cellular Biology of Malaria". These meetings will bring together leading international scientists from diverse disciplines including biochemistry, medicinal chemistry, vaccine research, molecular genetics, structural, cell biology and systems biology to focus on the most recent advances in malaria. The meeting will emphasize molecular and cellular aspects of the malaria parasite's basic biology, immunology, host-parasite-vector interactions and pathogenic mechanisms. The format will provide a stimulating forum to discuss cutting edge fundamental and applied research on malaria, with an emphasis on programs that contribute to the development of vaccines and drugs. The first GRC on Malaria was held in September 1997, and has become a well-established series of conferences that run every two years, and alternate between a meeting focused on basic oriented research and a meeting focused on more field and clinical aspects. The 2013 meeting will focus on the former: that is will emphasize basic research into host-parasite-vector interactions as well as the concepts around the development of novel interventions. The Malaria GRC has been extremely popular in previous years with one of the highest attendances among the Gordon Conferences and is usually oversubscribed. We also anticipate that the introduction of the first Malaria Gordon Research Seminar will promote active participation of young malaria researchers into the global collaborative efforts to combat this disease. The timing of this Malaria GRC in 2013 will coincide with the availability of advanced data from the first phase 3 clinical trials of a malaria vaccine involving ~10,000 African infants and children. Presentation of these results will be a major focus of the meeting. Against this, reports are beginning to emerge of parasites resistant to the newest anti-malarials spreading in Southeast Asia and the timing of the Malaria GRC will also be well suited to disseminate and discuss the very latest findings on this crucial topic. There is an urgent need to understand the emerging mechanism(s) of this resistance and of the ongoing requirements for new interventions and a deeper understanding of host-parasite-vector interactions. The 2013 Malaria GRC and its first associated GRS are important opportunities for established and emerging malaria research leaders to gather and address these issues under the auspices of a conference series that has a reputation for presentation of the latest unpublished data followed by vigorous and extensive discussion.