2013 Malaria Gordon Research Conference and Gordon Research Seminar

描述(由申请者提供)：2013年疟疾戈登研究会议(GRC)及其首届相关戈登研究研讨会(GRS)将集中讨论“疟疾的分子和细胞生物学”。这些会议将汇集来自不同学科的领先国际科学家，包括生物化学、药物化学、疫苗研究、分子遗传学、结构生物学、细胞生物学和系统生物学，重点关注疟疾的最新进展。会议将强调疟疾寄生虫的基本生物学、免疫学、宿主-寄生虫-媒介相互作用和致病机制的分子和细胞方面的问题。该形式将提供一个激动人心的论坛，讨论疟疾的尖端基础和应用研究，重点是有助于疫苗和药物开发的项目。关于疟疾的第一次全球疟疾研究会议于1997年9月举行，现已成为每两年举行一次的成熟的一系列会议，并在侧重于基础研究的会议和侧重于更多领域和临床方面的会议之间交替举行。2013年的会议将侧重于前者：即将强调对宿主-寄生虫-媒介相互作用的基础研究以及围绕开发新干预措施的概念。疟疾GRC在前几年非常受欢迎，是戈登会议中上座率最高的会议之一，而且通常会超额订阅。我们还预期，首次举办疟疾戈登研究研讨会将促进年轻的疟疾研究人员积极参与防治这一疾病的全球合作努力。2013年疟疾GRC的时间安排将与疟疾疫苗第一阶段3临床试验的先进数据的获得相吻合，该临床试验涉及约10,000名非洲婴儿和儿童。介绍这些成果将是会议的一个主要重点。有鉴于此，有关对最新抗疟疾药物产生抗药性的寄生虫在东南亚传播的报告开始出现，疟疾全球研究中心的召开时间也将非常适合传播和讨论关于这一关键主题的最新发现。迫切需要了解这种耐药性的新机制(S)，以及对新干预措施的持续需求和对宿主-寄生虫-媒介相互作用的更深入了解。2013年疟疾全球研究报告及其第一次相关的全球研究报告是在一系列会议的主持下，老牌和新兴的疟疾研究领导者收集和解决这些问题的重要机会，该系列会议以展示最新的未公布数据而闻名，随后进行了激烈和广泛的讨论。

DESCRIPTION (provided by applicant): The 2013 Malaria Gordon Research Conference (GRC) and its first associated Gordon Research Seminar (GRS) will focus on "Molecular and Cellular Biology of Malaria". These meetings will bring together leading international scientists from diverse disciplines including biochemistry, medicinal chemistry, vaccine research, molecular genetics, structural, cell biology and systems biology to focus on the most recent advances in malaria. The meeting will emphasize molecular and cellular aspects of the malaria parasite's basic biology, immunology, host-parasite-vector interactions and pathogenic mechanisms. The format will provide a stimulating forum to discuss cutting edge fundamental and applied research on malaria, with an emphasis on programs that contribute to the development of vaccines and drugs. The first GRC on Malaria was held in September 1997, and has become a well-established series of conferences that run every two years, and alternate between a meeting focused on basic oriented research and a meeting focused on more field and clinical aspects. The 2013 meeting will focus on the former: that is will emphasize basic research into host-parasite-vector interactions as well as the concepts around the development of novel interventions. The Malaria GRC has been extremely popular in previous years with one of the highest attendances among the Gordon Conferences and is usually oversubscribed. We also anticipate that the introduction of the first Malaria Gordon Research Seminar will promote active participation of young malaria researchers into the global collaborative efforts to combat this disease. The timing of this Malaria GRC in 2013 will coincide with the availability of advanced data from the first phase 3 clinical trials of a malaria vaccine involving ~10,000 African infants and children. Presentation of these results will be a major focus of the meeting. Against this, reports are beginning to emerge of parasites resistant to the newest anti-malarials spreading in Southeast Asia and the timing of the Malaria GRC will also be well suited to disseminate and discuss the very latest findings on this crucial topic. There is an urgent need to understand the emerging mechanism(s) of this resistance and of the ongoing requirements for new interventions and a deeper understanding of host-parasite-vector interactions. The 2013 Malaria GRC and its first associated GRS are important opportunities for established and emerging malaria research leaders to gather and address these issues under the auspices of a conference series that has a reputation for presentation of the latest unpublished data followed by vigorous and extensive discussion.