2012 Ligand Recognition and Molecular Gating Gordon Research Conference

描述：配基识别和分子门控戈登研究会议将于2012年1月15-20日在加利福尼亚州文图拉举行。会议的广泛和长期目标是增加我们对完整的膜蛋白如何结合或识别配体(离子、小分子、蛋白质)以及如何跨膜传递信号的理解。会议的主要目的是分享关于离子通道、G蛋白偶联受体和所有类型的转运蛋白的最新知识，重点是将高分辨率结构数据与功能信息相结合来了解机制。在这三类不同的膜蛋白中，一个统一的主题是配体结合、门控和/或运输涉及构象变化。确定的、与机械相关的全功能蛋白质构象的特征将是2012年会议的一个重点。该项目将有大约40名演讲者，他们是膜蛋白研究领域的知名领导者，以及有前途的年轻研究人员。九节课将广泛讨论涉及感觉转导的离子通道、钾通道和谷氨酸受体通道、次级转运体、ATP驱动的转运体、2-肾上腺素能受体、多巴胺受体和其他GPCRs的结构和机制。还将举行关于膜蛋白结构生物学和脂蛋白相互作用的新方法的会议。戈登配基识别和分子门控研究会议的目标是通过聚集这个社区的一些最顶尖的科学家来展示和比较结果，讨论新的想法，并建立合作，从而促进膜蛋白研究领域的进步。

DESCRIPTION: The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held on Jan 15 - 20, 2012, in Ventura, CA. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins) and transmit signals across membranes. The main objective of the conference is to share the newest knowledge on ion channels, G protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional information to understand mechanisms. A unifying theme in these three different classes of membrane proteins is that ligand binding, gating, and/or transport involves conformational changes. The characterization of defined, mechanistically relevant conformations of fully functional protein will be a focus of the 2012 conference. The program will have about 40 speakers, well-established leaders in the field of membrane protein research as well as promising young investigators. Nine sessions will broadly address structure and mechanism of ion channels involved in sensory transduction, potassium channels and glutamate receptor channels, secondary transporters, ATP-driven transporters, 2-adrenergic receptors, dopamine receptors and other GPCRs. There will also be sessions on new approaches for membrane protein structural biology and on lipid-protein interactions. The goal of the Gordon Research Conference on Ligand Recognition and Molecular Gating is to stimulate advances in this area of membrane protein research by bringing together some of the foremost scientists in this community to present and compare results, discuss new ideas, and establish collaborations.