2012 Ligand Recognition and Molecular Gating Gordon Research Conference

2012年配体识别与分子门控戈登研究会议

• 批准号: 8252998
• 负责人: Nancy Ryan Gray
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252998
• 关键词: ATP-Binding Cassette Transporters; Address; Adrenergic Receptor; Animal Model; Area; Behavior; Binding; Biochemistry; Cardiovascular Diseases; Cellular biology; Collaborations; Communities; Critiques; Cystic Fibrosis; Data; Development; Disease; Dopamine Receptor; Employee Strikes; Ensure; Epilepsy; Eukaryota; Evaluation; Financial Support; Future; G Protein-Coupled Receptor Genes; G-Protein-Coupled Receptors; Generations; Glutamate Receptor; Goals; Health; Human; Hypertension; Individual; Integral Membrane Protein; Ion Channel; Ions; Knowledge; Lead; Ligand Binding; Ligands; Link; Lipids; Malabsorption Syndromes; Malignant Neoplasms; Membrane; Membrane Proteins; Membrane Structure and Function; Mental Depression; Mission; Molecular; Molecular Conformation; Nervous system structure; Neurodegenerative Disorders; Neurotransmitters; Pharmacologic Substance; Physiological; Physiology; Postdoctoral Fellow; Potassium Channel; Potassium Glutamate; Process; Protein Binding; Proteins; Recruitment Activity; Regulation; Research; Research Personnel; Resolution; Role; Science; Scientist; Seasons; Senior Scientist; Sensory; Signal Transduction; Signaling Protein; Structure; Study Section; System; Technology; Therapeutic Agents; Training; Update; Vision; Work; Writing; base; cohort; deafness; design; experience; graduate student; improved; insight; meetings; molecular recognition; multidisciplinary; nervous system disorder; novel strategies; novel therapeutics; programs; receptor; research study; skin disorder; small molecule; structural biology; success; symposium

DESCRIPTION: The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held on Jan 15 - 20, 2012, in Ventura, CA. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins) and transmit signals across membranes. The main objective of the conference is to share the newest knowledge on ion channels, G protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional information to understand mechanisms. A unifying theme in these three different classes of membrane proteins is that ligand binding, gating, and/or transport involves conformational changes. The characterization of defined, mechanistically relevant conformations of fully functional protein will be a focus of the 2012 conference. The program will have about 40 speakers, well-established leaders in the field of membrane protein research as well as promising young investigators. Nine sessions will broadly address structure and mechanism of ion channels involved in sensory transduction, potassium channels and glutamate receptor channels, secondary transporters, ATP-driven transporters, 2-adrenergic receptors, dopamine receptors and other GPCRs. There will also be sessions on new approaches for membrane protein structural biology and on lipid-protein interactions. The goal of the Gordon Research Conference on Ligand Recognition and Molecular Gating is to stimulate advances in this area of membrane protein research by bringing together some of the foremost scientists in this community to present and compare results, discuss new ideas, and establish collaborations. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference. Understanding the structure and function of these membrane bound molecules is one of the most important goals of the 21st century, both for science and for development of new therapeutics. Results discussed and new experiments designed have impact on areas such as cancer (ABC transporters), vision/depression/cardiovascular diseases (G-protein coupled receptors), neurodegenerative diseases, skin diseases, deafness, developmental abnormalities and neurological diseases such as epilepsy (ion channels). Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.

Gordon Research Conference on Ligand Recognition and Molecular Gating将于2012年1月15日至20日在加利福尼亚州文图拉举行。会议的广泛和长期目标是增加我们对膜蛋白如何结合或识别配体（离子，小分子，蛋白质）并跨膜传输信号的理解。会议的主要目的是分享关于离子通道，G蛋白偶联受体和所有类型转运蛋白的最新知识，重点是将高分辨率结构数据与功能信息相结合，以了解机制。这三种不同类型的膜蛋白的统一主题是配体结合、门控和/或转运涉及构象变化。确定的，机械相关的构象的全功能蛋白质的表征将是2012年会议的重点。该计划将有大约40名发言人，在膜蛋白研究领域的知名领导者以及有前途的年轻研究人员。九个会议将广泛讨论参与感觉转导的离子通道、钾通道和谷氨酸受体通道、二级转运蛋白、ATP驱动的转运蛋白、2-肾上腺素能受体、多巴胺受体和其他GPCR的结构和机制。还将有关于膜蛋白结构生物学和脂质-蛋白质相互作用的新方法的会议。配体识别和分子门控的戈登研究会议的目标是通过汇集该社区中一些最重要的科学家来展示和比较结果，讨论新的想法并建立合作来刺激膜蛋白研究这一领域的进展。 公共卫生相关性：该应用的健康相关性在于，目前超过50%的药物靶点是本次会议上讨论的类型的整合膜蛋白。了解这些膜结合分子的结构和功能是21世纪世纪科学和新疗法开发的最重要目标之一。讨论的结果和设计的新实验对癌症（ABC转运蛋白）、视力/抑郁症/心血管疾病（G蛋白偶联受体）、神经变性疾病、皮肤病、耳聋、发育异常和癫痫等神经系统疾病（离子通道）等领域产生了影响。 免责声明：请注意，以下评论是由审查员在研究部分会议之前准备的，并且以基本上未经编辑的形式提供。 虽然审查人员有机会根据小组讨论情况更新或修订其书面评价，但不能保证在会议讨论之后更新了个人评论。 因此，评论可能无法完全反映小组讨论结束时个人评论者的最终意见或小组的最终多数意见。因此，讨论的简历和摘要是评审员在会议上实际认为关键的最后一句话。