2011 Cell-Cell Fusion Gordon Research Conference and Seminar

2011细胞-细胞融合戈登研究会议暨研讨会

• 批准号: 8127175
• 负责人: Nancy Ryan Gray
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-06 至 2011-10-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127175
• 关键词: Address; Affect; Aging; Animal Model; Award; Biological; Cell fusion; Cell membrane; Cells; Communities; Crystalline Lens; Cytokinesis; Defect; Development; Discipline; Disease; Educational workshop; Endocytosis; Event; Exocytosis; Feedback; Funding; Funding Agency; Future; Future Generations; Health; Hereditary Disease; In Vitro; Individual; Infertility; International; Knowledge; Life; Location; Malignant Neoplasms; Membrane; Membrane Fusion; Methodology; Methods; Molecular; Mus; Muscle; Myoblasts; Myopathy; Names; Nature; Neurodegenerative Disorders; New England; Organ; Osteogenesis; Participant; Phase; Placenta; Postdoctoral Fellow; Process; Rare Diseases; Recording of previous events; Request for Applications; Research; Research Personnel; Research Project Grants; Science; Scientist; Sexual Development; Sister; Stem Cell Research; Stem cells; Syndrome; Time; Training; Translating; Travel; Universities; Viral; Virus Diseases; Work; abstracting; base; bone; cancer stem cell; design; developmental genetics; egg; fascinate; fly; fundamental research; fungus; graduate student; high throughput screening; human disease; in vivo; malformation; meetings; member; multidisciplinary; novel; novel therapeutics; pathogen; planetary Atmosphere; posters; programs; sex; single molecule; sperm cell; stem cell biology; symposium; trafficking

DESCRIPTION (Provided by Applicant): The Gordon Research Conference (GRC) on Cell-Cell Fusion will provide scientists from a wide range of disciplines with the newest research findings on the functions of cell fusion in development in a number of model organisms and in a variety of diseases. The emphasis will be on emerging universal mechanisms and future applications to cancer and stem cell research. This research conference will be the third Cell-Cell Fusion GRC and it is part of over 150 conferences that will be organized in 2011 by the GRC, an organization internationally known for the cutting edge nature of its meetings. Attendance at the meeting has grown steadily since its inception five years ago, and in 2011 the organizers expect to have 140 participants. The 2011 GRC on Cell-Cell Fusion will be held August 7-12, 2011 at the University of New England in Biddeford, ME. The program for the meeting described in this application has been designed around the theme of "Cell Fusion in Sex, Life, Development, and Disease". The organizer will deal mostly on the fundamental process of cell fusion during health and disease as well as the relationship between cell fusion and the larger fields of membrane fusion and fission during exocytosis, endocytosis, viral entry, and cytokinesis. The cell fusion community is entering a particularly fascinating phase as the fundamental principles of fusion emerging from theoretical analyses and studies on viral entry and intracellular trafficking start to be applied to understanding the functions and mechanisms of cell-cell fusion in development as well as disease. Important processes such as membrane fusion and fission, egg-sperm fusion, formation of bones, muscles, eye lens, stem cells, placenta, rare genetic diseases, and the invasion of cells by pathogens will be covered in eight sessions. This progress is being helped by classic and new methodology, including high throughput screening, developmental genetics in model organisms (e.g., fungi, flies, worms, and mice), and single-molecule biophysical methods. Exciting developments will be covered by the invited speakers, along with the latest progress on the basic mechanisms and applications of cell membrane fusion in vitro and in vivo. In addition there will be one round table discussion on myoblast fusion, a hotly debated topic that will encourage wide participation and scholarly organized discussions. The first Gordon-Kenan Research Seminar (GRS) on Cell-Cell fusion will be held August 6-7, 2011. This new GRS is organized by graduate students and postdoctoral fellows, and the activities during the GRS will be oriented to junior investigators and are intended to: (1) provide them with the basic background on mechanisms involved in membrane fusion in health and disease necessary to maximize their understanding of the science which will be discussed in the subsequent conference, (2) receive feedback on their ongoing research projects from experts in the field, and (3) facilitate their interaction with senior members of this scientific community to promote networking between junior and more senior researchers in the field. It is fully anticipate that the scientific discussions, research talks, poster sessions, and other informal interactions among the participants of this conference will contribute to advancing our understanding of novel molecular mechanisms involved in cell fusion during normal development as well as in human diseases, and will set the basis for the development of multidisciplinary projects aimed at discovering new treatments for these disorders. NARRATIVE: The Cell-Cell Fusion Gordon Research Conference (GRC) together with the first sister Gordon-Kenan Research Seminar (GRS) will bring leaders in diverse scientific disciplines together with graduate students and postdoctoral fellows constituting the future generation of researchers in the emerging field of cell fusion. The scientific presentations, discussions, round table discussions, as well as workshops during the GRC and GRS conferences on cell-cell fusion are tailored to expand our knowledge on the mechanisms by which membranes fuse in model organisms, and may contribute to our understanding of the first events in sexual development, the formation of many organs, cancer, stem cell biology, and rare diseases. The exciting, friendly, and multidisciplinary atmosphere that has traditionally characterized the Cell-Cell Fusion GRC will provide the ideal setting for the intellectual development and implementation of groundbreaking approaches to treat some cancers, as well as use stem cells to address fundamental biological questions and diseases.

描述（由申请人提供）：细胞-细胞融合戈登研究会议（GRC）将为来自广泛学科的科学家提供关于细胞融合在许多模式生物和各种疾病中的发育功能的最新研究结果。 重点将是新兴的普遍机制和未来的应用，癌症和干细胞研究。 这次研究会议将是第三次细胞-细胞融合GRC，它是GRC将在2011年组织的150多个会议的一部分，GRC是一个以其会议的前沿性质而闻名的国际组织。 自五年前成立以来，参加会议的人数稳步增加，2011年组织者预计将有140人参加。 2011年细胞-细胞融合研讨会将于2011年8月7日至12日在新英格兰比德福德大学举行。本申请中描述的会议计划是围绕“性、生命、发育和疾病中的细胞融合”这一主题设计的。 组织者将主要处理健康和疾病期间细胞融合的基本过程，以及细胞融合与胞吐，内吞，病毒进入和胞质分裂期间膜融合和裂变的更大领域之间的关系。 细胞融合社区正在进入一个特别迷人的阶段，融合的基本原则出现的理论分析和研究病毒进入和细胞内运输开始被应用于了解细胞-细胞融合的功能和机制，在发展以及疾病。 重要的过程，如膜融合和分裂，卵精子融合，形成骨骼，肌肉，眼睛透镜，干细胞，胎盘，罕见的遗传疾病，和细胞的病原体入侵将在八个会议。 这一进展得到了经典和新方法的帮助，包括高通量筛选、模式生物的发育遗传学（例如，真菌、苍蝇、蠕虫和小鼠）和单分子生物物理方法。 邀请的演讲者将涵盖令人兴奋的发展，沿着细胞膜融合的基本机制和体外和体内应用的最新进展。 此外，将有一个关于成肌细胞融合的圆桌讨论，这是一个激烈辩论的话题，将鼓励广泛参与和学术组织的讨论。 第一次戈登凯南研究研讨会（GRS）细胞融合将于2011年8月6日至7日举行。 这个新的GRS由研究生和博士后研究员组织，GRS期间的活动将面向初级研究人员，旨在：（1）为他们提供必要的基本背景，以最大限度地提高他们对科学的理解，这将在随后的会议上讨论，（2）从该领域的专家那里获得关于他们正在进行的研究项目的反馈，（3）促进他们与科学界高级成员的互动，以促进该领域初级和高级研究人员之间的网络联系。 我们完全可以预期，本次会议参与者之间的科学讨论，研究会谈，海报会议和其他非正式互动将有助于促进我们对正常发育过程中细胞融合以及人类疾病中所涉及的新分子机制的理解，并将为旨在发现这些疾病的新疗法的多学科项目的发展奠定基础。 说明：细胞-细胞融合戈登研究会议（GRC）与第一个姐妹戈登-凯南研究研讨会（GRS）将汇集不同科学学科的领导者，以及研究生和博士后研究员，他们将成为细胞融合新兴领域的未来一代研究人员。 科学报告，讨论，圆桌会议讨论，以及研讨会在GRC和GRS会议上细胞融合是量身定制的，以扩大我们的知识膜融合在模型生物体的机制，并可能有助于我们的性发育的第一个事件的理解，许多器官的形成，癌症，干细胞生物学和罕见疾病。 令人兴奋的，友好的，多学科的气氛，传统上细胞融合GRC的特点将提供理想的设置为智力开发和实施突破性的方法来治疗某些癌症，以及使用干细胞来解决基本的生物学问题和疾病。