Extended Treatment for Smoking Cessation

延长戒烟治疗

• 批准号: 8505434
• 负责人: SEAN P. DAVID
• 金额: $ 51.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8505434
• 关键词: 21 year old; Abstinence; Address; Adolescent; Adult; Air; Behavioral; Bupropion; Carbon Monoxide; Cells; Cellular Phone; Chronic; Clinical Trials; Cocaine Dependence; Cognitive; Cognitive Therapy; Computers; Controlled Study; Counseling; County; Cox Proportional Hazards Models; Detection; Development; Disease; Drug Addiction; Early Diagnosis; Eligibility Determination; Event History Analysis; Intention; Knowledge; Logistic Regressions; Maintenance; Measures; Mediator of activation protein; Modeling; Monitor; Nicotine; Opiate Addiction; Outcome; Outcome Measure; Participant; Pharmacotherapy; Phase; Population Study; Prevalence; Probability; Public Health; Randomized; Recommendation; Relapse; Reporting; Research; Sampling; Selection Bias; Smoke; Smoker; Smoking; Societies; Supportive care; Survival Analysis; Tail; Target Populations; Techniques; Technology; Telephone; Time; Tobacco; Treatment Failure; Withholding Treatment; Work; Writing; alcoholism therapy; base; cigarette smoking; craving; depressive symptoms; design; disorder later incidence prevention; experience; follow-up; meetings; nicotine patch; open label; primary outcome; public health relevance; rapid detection; response; secondary outcome; self help; skills training; smoking cessation; success; treatment planning; treatment response; varenicline

DESCRIPTION (provided by applicant): Research indicates that drug addictions are chronic, relapsing disorders requiring extended therapy and follow-up. However, only a few smoking cessation trials have examined the utility of extended therapy models. We propose to examine the efficacy of a multi-component extended cigarette smoking cessation treatment in promoting longer-term smoking abstinence. Adult smokers and adolescent smokers (18 - 21) years of age will serve as the target population for this study. A total of 400 smokers will be randomized. Treatment will include both open label and extended treatment phases. Open Label Treatment. All 400 smokers will receive nicotine patch (21mg), bupropion (300mg) and individualized cognitive and behavioral skills training (ST). Nicotine patches and bupropion will be provided for 10 weeks and cognitive behavior therapy (CBT) will be provided for 26 weeks. Those who fail to respond to bupropion and nicotine patch will be switched to varenicline through week 26. Those who relapse beyond week 10 will re-start bupropion and nicotine patch through week 26. Extended Treatment. Following open label treatment, half (n=200) will receive CBT from week 26 - week 52. CBT will include both therapist-directed and self-directed relapse prevention skills training. In addition, telephone counseling will be provided in conjunction with voicemail, computer and cell phone technology enabling monitoring of treatment plan implementation and early detection of smoking "slips" and rapid response by treatment staff. Control. Remaining participants (n=200) will receive monthly telephone support calls from week 26 - week 52. The proposed study will address several important gaps in our knowledge of effective smoking cessation treatment. First, this will be one of only a handful of studies to investigate the effects of extended therapy for smoking cessation. Second, this will be among the first controlled studies to examine the effects of a multi-component treatment employing pharmacotherapy, intensive behavioral skills training, self-help skills training and rapid slip detection and response via voicemail, cell phone and telephone counseling.

描述（由申请人提供）：研究表明，药物成瘾是一种慢性、复发性疾病，需要长期治疗和随访。然而，只有少数戒烟试验检验了扩展治疗模式的效用。我们建议检验多组分延长戒烟治疗在促进长期戒烟方面的功效。成年吸烟者和青少年吸烟者（18 - 21岁）将作为本研究的目标人群。总共400名吸烟者将被随机抽取。治疗将包括开放标签和延长治疗阶段。开放标签治疗。所有400名吸烟者将接受尼古丁贴片（21毫克）、安非他酮（300毫克）和个性化认知和行为技能训练（ST）。提供尼古丁贴片和安非他酮10周，提供认知行为治疗（CBT） 26周。那些对安非他酮和尼古丁贴片没有反应的人将在26周内改用伐尼克兰。那些在第10周后复发的人将在第26周重新开始服用安非他酮和尼古丁贴片。延长治疗。在开放标签治疗后，一半（n=200）将从第26周开始接受CBT治疗。CBT将包括治疗师指导和自我指导的复发预防技能培训。此外，还将提供电话咨询，并结合语音信箱、电脑和手机技术，监测治疗计划的实施情况，及早发现吸烟“失误”，并使治疗人员迅速作出反应。控制。剩余的参与者（n=200）将从第26周开始每月接到电话支持电话。拟议的研究将解决我们在有效戒烟治疗知识方面的几个重要空白。首先，这将是调查延长戒烟治疗效果的为数不多的研究之一。其次，这将是第一批检验多成分治疗效果的对照研究，包括药物治疗、强化行为技能培训、自助技能培训以及通过语音邮件、手机和电话咨询快速检测和反应的方法。

项目成果

Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention.

• DOI: 10.1016/j.tics.2014.02.010
• 发表时间: 2014-05
• 期刊: TRENDS IN COGNITIVE SCIENCES
• 影响因子: 19.9
• 作者: Ioannidis, John P. A.;Munafo, Marcus R.;Fusar-Poli, Paolo;Nosek, Brian A.;David, Sean P.
• 通讯作者: David, Sean P.

Extended treatment for cigarette smoking cessation: a randomized control trial.

戒烟的延长治疗：一项随机对照试验。

• DOI: 10.1111/add.13806
• 发表时间: 2017
• 期刊: Addiction (Abingdon, England)
• 作者: Laude,JenniferR;Bailey,SteffaniR;Crew,Erin;Varady,Ann;Lembke,Anna;McFall,Danielle;Jeon,Anna;Killen,Diana;Killen,JoelD;David,SeanP
• 通讯作者: David,SeanP

Potential reporting bias in fMRI studies of the brain.

• DOI: 10.1371/journal.pone.0070104
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: David SP;Ware JJ;Chu IM;Loftus PD;Fusar-Poli P;Radua J;Munafò MR;Ioannidis JP
• 通讯作者: Ioannidis JP